Group items tagged SERMs - Dr. Goodyear

Expressions of vascular endothelial growth factor an... [Thyroid. 2010] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...20017619

estrogen SERMs tamoxifen raloxifene thyroid VEGF

shared by Nathan Goodyear on 16 Nov 11 - No Cached

Nathan Goodyear on 16 Nov 11

estrogen and SERMS (tamoxifen, raloxifene) shown to stimulate growth of thyroid cells via regulation of vascularization. Think about the impact of the estrogen on other cells and tissue in the body.

<div class="cArrow"> </div><div class="cContentInner">estrogen and SERMS (tamoxifen, raloxifene) shown to stimulate growth of thyroid cells via regulation of vascularization. Think about the impact of the estrogen on other cells and tissue in the body.</div>

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BMC Cancer | Full text | Estrogen receptor alpha/beta ratio and estrogen rece... - 0 views

www.biomedcentral.com/...425

breast cancer ER alpha ER-alpha ER beta ER-beta SERM tamoxifen anastrazole women hormone hormones female

shared by Nathan Goodyear on 08 Oct 14 - No Cached

75% of human BCs express estrogen receptors (ERs)
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Nathan Goodyear on 08 Oct 14

ER beta expression and the ratio of ER alpha/ER beta is important in prognosis and effectiveness of SERM therapy like tamoxifen. This study looked at the aromatase inhibitor anastrazole as well.

<div class="cArrow"> </div><div class="cContentInner">ER beta expression and the ratio of ER alpha/ER beta is important in prognosis and effectiveness of SERM therapy like tamoxifen. This study looked at the aromatase inhibitor anastrazole as well. </div>

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Selective Estrogen Receptor Modulators and Phytoestrogens - 0 views

www.ncbi.nlm.nih.gov/...PMC2587438

phytoestrogens selective estrogen receptor modulators cancer SERMs

shared by Nathan Goodyear on 31 Jul 20 - No Cached

Nathan Goodyear on 31 Jul 20

Nice review of natural SERMs as natural alternatives to Tamoxifen

<div class="cArrow"> </div><div class="cContentInner">Nice review of natural SERMs as natural alternatives to Tamoxifen</div>

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Inhibitory effects of pharmacological doses of melatonin on aromatase activity and expr... - 0 views

www.nature.com/6603935

melatonin SERM SEEM selective estrogen receptor modulators

shared by Nathan Goodyear on 17 Jan 22 - No Cached

Nathan Goodyear on 17 Jan 22

melatonin acts as SEEM and SERM

<div class="cArrow"> </div><div class="cContentInner">melatonin acts as SEEM and SERM</div>

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High Estrogen in Men After Injectable Testo... [Am J Mens Health. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24928451

aromatase estrogen aromatase inhibition aromatase inhibitor men's health libido low T Testosterone Estradiol men male hormone hormones

shared by Nathan Goodyear on 16 Jun 14 - No Cached

Nathan Goodyear on 16 Jun 14

Again, Testosterone and here Estradiol are merely there for libido and sex. What tunnel vision?! What about hsCRP? What about fibrinogen? What about IL-1beta? What about TNF-alpha? These inflammatory cytokines have all been reported to elevate as a result of estrogen production in men. And PSA? No mention of it here. This linear, tunnel vision thinking on hormones has got to stop! The study points out that all clients were using AIs and SERMs irregardless of whether they had elevated estrogens or not. That is not a well designed study. One group should have had AI's if elevated estrogens were present and another group should not--this would compare the effects of aromatase activity. Second, this was simply a retrospective chart review. Third, a 50% conversion of 34,000 + men is very high when you look at the literature. Fourth, they point to gynecomastia as a means of negative? The cardiovascular implications are more significant. These studies just seem to focus on superficial things. Fifth, did libido problems exist before? What were the free levels? This falls in the paucity of data (2 studies) that point to excessive lowering of estradiol effecting libido and sexual performance.

<div class="cArrow"> </div><div class="cContentInner">Again, Testosterone and here Estradiol are merely there for libido and sex. What tunnel vision?! What about hsCRP? What about fibrinogen? What about IL-1beta? What about TNF-alpha? These inflammatory cytokines have all been reported to elevate as a result of estrogen production in men. And PSA? No mention of it here. This linear, tunnel vision thinking on hormones has got to stop! The study points out that all clients were using AIs and SERMs irregardless of whether they had elevated estrogens or not. That is not a well designed study. One group should have had AI's if elevated estrogens were present and another group should not--this would compare the effects of aromatase activity. Second, this was simply a retrospective chart review. Third, a 50% conversion of 34,000 + men is very high when you look at the literature. Fourth, they point to gynecomastia as a means of negative? The cardiovascular implications are more significant. These studies just seem to focus on superficial things. Fifth, did libido problems exist before? What were the free levels? This falls in the paucity of data (2 studies) that point to excessive lowering of estradiol effecting libido and sexual performance. </div>

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Estrogen receptor transcription and transactivation: Estrogen receptor alpha and estrog... - 1 views

www.ncbi.nlm.nih.gov/...PMC138655

ER alpha ER beta estrogen receptors estrogen receptor alpha estrogen receptor beta estrogen cancer

shared by Nathan Goodyear on 06 Oct 18 - No Cached

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Nathan Goodyear on 06 Oct 18

estrogen receptors are not created equally. ER-alpha is the predominant pro-stimulatory signal receptor, whereas the ER-beta is the inhibitory receptor signaling pathway. SERMS are not created equally as well dependent on how they bind the respective ER receptors.

<div class="cArrow"> </div><div class="cContentInner">estrogen receptors are not created equally. ER-alpha is the predominant pro-stimulatory signal receptor, whereas the ER-beta is the inhibitory receptor signaling pathway. SERMS are not created equally as well dependent on how they bind the respective ER receptors.</div>

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walterbradford on 12 Oct 18

Thank you for sharing

<div class="cArrow"> </div><div class="cContentInner">Thank you for sharing</div>

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An Overview of Melatonin and Breast Cancer | Natural Medicine Journal - 0 views

www.naturalmedicinejournal.com/...ew-melatonin-and-breast-cancer

melatonin cancer

shared by Nathan Goodyear on 31 May 18 - No Cached

Overall its effect on cancer cells is oncostatic at physiological levels, or cytotoxic at higher concentrations
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direct antioxidant, antimitotic, antiestrogenic, prodifferentiating and antimetastatic effects have been well characterized
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hypothalamic-pituitary axis (HPA) and immune system
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On a cellular level, melatonin acts as a selective estrogen receptor modulator (SERM) through decreased expression of estrogen receptor alpha and reduction in the ability of estrogen-estrogen receptor alpha (ERα) complex to bind to the estrogen response element (ERE) on DNA
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Melatonin also acts as a selective estrogen enzyme modulator (SEEM), reducing the activity of aromatase in cells
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Nathan Goodyear on 31 May 18

review of melatonins activity in cancer battle.

<div class="cArrow"> </div><div class="cContentInner">review of melatonins activity in cancer battle.</div>

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