The association between blood lead levels and increased all-cause and cardiovascular mortality was observed at substantially lower blood lead levels than previously reported. Despite the marked decrease in blood lead levels over the past 3 decades, environmental lead exposures remain a significant determinant of cardiovascular mortality in the general population, constituting a major public health problem
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Blood Lead Below 0.48 μmol/L (10 μg/dL) and Mortality Among US Adults - 0 views
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Lead levels lead to increased risk of cardiovascular events at lower than previous thought levels. Levels as low as 2mcg/dl found to be associated with increased cardiovascular mortality. This equates to 38% of Americans. The author concludes with this statement, "Although a 10-fold decline in blood lead levels has occurred in the United States in recent decades, current levels remain orders of magnitude higher than in pre industrialized times".
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Blood Lead Below 0.48 {micro}mol/L (10 {micro}g/dL) and Mortality Among US Adults -- Me... - 0 views
www.circ.ahajournals.org/...CIRCULATIONAHA.106.628321v1
lead toxicity cardiovascular disease exposure
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Occupational Lead Poisoning - February 15, 1998 - American Family Physician - 0 views
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The freely diffusible plasma fraction is distributed extensively throughout tissues, reaching highest concentrations in bone, teeth, liver, lungs, kidneys, brain and spleen
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Inorganic lead does not undergo any metabolic transformation or digestion in the intestines, or detoxification in the liver.5
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The total bodily content of lead is called the body burden; in a steady state, about 90 percent of the body burden is bound to bone.2
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n general, lead is excreted quite slowly from the body (with the biologic half-life estimated at 10 years). Since excretion is slow, accumulation in the body occurs easily.2
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hronic toxicity is an insidious illness with protean manifestations.3,6 Symptoms may include arthralgias, headache, weakness, depression, loss of libido, impotence and vague gastrointestinal difficulties.
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Chelation Therapy for Patients with Elevated Body Lead Burden and Progressive Renal Ins... - 0 views
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helation therapy seems to slow the progression of renal insufficiency in patients with mildly elevated body lead burden.
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implies that long-term exposure to low levels of environmental lead may be associated with impaired renal function in patients with chronic renal disease.
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US lowers cutoff for lead poisoning in young kids | Fox News - 0 views
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Toxicity of the spike protein of COVID-19 is a redox shift phenomenon: A novel therapeu... - 0 views
www.sciencedirect.com/...S0891584923005014
COVID19 COVID-19 cancer inflammation SARS-CoV-2 spike proteins COVID spikeopathy
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Long-term effects include redox shift and cellular anabolism as a result of the Warburg effect and mitochondrial dysfunction
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Long-term effects include redox shift and cellular anabolism as a result of the Warburg effect and mitochondrial dysfunction
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Long-term effects include redox shift and cellular anabolism as a result of the Warburg effect and mitochondrial dysfunction
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Long-term effects include redox shift and cellular anabolism as a result of the Warburg effect and mitochondrial dysfunction
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Lipoic acid and Methylene Blue have been shown to enhance the mitochondrial activity, relieve the Warburg effect and increase catabolism
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Lipoic acid and Methylene Blue have been shown to enhance the mitochondrial activity, relieve the Warburg effect and increase catabolism
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Lipoic acid and Methylene Blue have been shown to enhance the mitochondrial activity, relieve the Warburg effect and increase catabolism
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Methylene Blue, Chlorine dioxide and Lipoic acid may help reduce long-term Covid-19 effects by stimulating the catabolism
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Methylene Blue, Chlorine dioxide and Lipoic acid may help reduce long-term Covid-19 effects by stimulating the catabolism
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Methylene Blue, Chlorine dioxide and Lipoic acid may help reduce long-term Covid-19 effects by stimulating the catabolism
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direct consequence of redox iMeBalance, itself a consequence of decreased energy yield by the mitochondria
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direct consequence of redox iMeBalance, itself a consequence of decreased energy yield by the mitochondria
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mitochondrial dysfunction and increased levels of lactate, which are important characteristics of metabolic shift and Warburg effect in many diseases
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mitochondrial dysfunction and increased levels of lactate, which are important characteristics of metabolic shift and Warburg effect in many diseases
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cell division is the most sophisticated way to release entropy
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redox signaling plays an important role in regulating immune function and inflammation, and disruptions in this signaling can lead to excessive cytokine production and immune system activation
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reduced extracellular environment in the elderly and the increased susceptibility to Covid-19 infection
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reduced extracellular environment in the elderly and the increased susceptibility to Covid-19 infection
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Redox signaling tightly modulates the inflammatory response and oxidative stress has been reported in acute Covid-19
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People at high risk are the elderly, patients suffering from metabolic syndrome such as obesity, or those suffering from chronic diseases such as cancer or inflammation
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COVID-19 patients with severe disease have higher levels of oxidative stress markers and lower antioxidant levels
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oxidative stress can activate the NLRP3 inflammasome, which is a protein complex that plays a key role in the cytokine storm
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inflammation leads to the formation of ROS and RNS, while redox iMeBalance results in cellular damage, which in turn triggers an inflammatory response
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persistently elevated mtROS triggers endothelial dysfunction and inflammation, which results in a vicious loop involving ROS, inflammation, and mitochondrial dysfunction
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IL-2 is highly up-regulated in Covid-19 patients [37], and IL-2 is known to significantly stimulate the generation of NO in patients
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Elevated levels of lactate, a characteristic of the Warburg effect, were also reported in the high-risk Covid-19
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vaccinated with RNA or DNA vaccines triggering the synthesis of the viral spike protein in human cells
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viral reactivation in varicella-zoster virus [55] or hepatitis [56], coagulopathy and resulting stroke and myocarditis following both DNA-based vaccines [57] and RNA-based vaccines
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characteristic of the Warburg effect is present in almost every disease and appears to be a central feature in most of the hallmarks of cancer
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inflammation, mitochondrial dysfunction and increased lactate concentrations in the extracellular fluid
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As the mitochondria are impaired, the infected cell cannot catabolize efficiently. It will release lactic acid in the blood stream
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Striking similarities are seen between cancer, Alzheimer's disease and Covid-19, all related to the Warburg effect
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Cancer, inflammation, Alzheimer's, and Parkinson's diseases share a common peculiarity, the inability of the cell to export entropy outside the body in the harmless form of heat
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MEB relieves the Warburg effect [87], improves memory [77], is active in the treatment of depressive episodes [79,80] and reduces the importance of ischemic strokes
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MEB relieves the Warburg effect [87], improves memory [77], is active in the treatment of depressive episodes [79,80] and reduces the importance of ischemic strokes
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It has been shown that Covid-19-patients treated with MEB, have a significant reduction in hospital stay duration and mortality
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MeB + can take a pair of electrons (of H atoms) and MeBH can release this pair easily, so that MeB is partially recycled like a catalyst
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MeB acts as an electron bridge between a donor (FADH2, FMNH, NADH) and an acceptor (complex IV of ETC or oxygen itself)
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As a coenzyme of pyruvate dehydrogenase (PDH), alpha-lipoic acid (ALA) initiates the formation of acetyl-CoA to feed the TCA cycle
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ALA enhances the catabolism of carbon. cycle and therefore may reduce the Warburg effect and consequently, lactate production
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Methylene Blue plays a similar role after the TCA cycle, by carrying electrons to complex IV of the electron transport chain
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Drugs such as lipoic acid and MeB, which target the metabolism, decrease the redox shift by increasing catabolism
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Blood Lead Levels and Death from All Causes, Cardiovascular Disease, and Cancer: Result... - 0 views
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Gut microbe levels are linked to type 2 diabetes and obesity -- ScienceDaily - 0 views
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Individuals with obesity and type II Diabetes been found to have significantly different gut bacteria populations compared to healthy individuals. This is not new information. The firmicutes:bacteroidetes ratio has been long known to be elevated in obese individuals vs those that are lean. The question here is cause and effect. Is the change in the bacterial population leading to obesity and type II diabetes? Or is diabetes and obesity leading to changes in the bacterial population? A heavy-laden carb diet is know to lead to a change to a more unhealthy gut bacterial population--maybe it is just a product of diet? Maybe it is effected by vaginal delivery vs cesarean delivery? Maybe breast feeding plays a role. Maybe, all the above is required. The point is that the cause of obesity and type II diabetes may have its origins deep, deep in the...well you know. http://ow.ly/yqDML
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Chronic lead exposure may be associated with erect... [J Sex Med. 2007] - PubMed - NCBI - 0 views
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Blood Lead Is a Predictor of Homocysteine Levels: Abstract and Introduction - 0 views
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These results suggest that homocysteine could be a mechanism that underlies the effects of lead on the cardiovascular and central nervous systems, possibly offering new targets for intervention to prevent the long-term consequences of lead exposure
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Low-level lead exposure, metabolic syndrome, and h... [Environ Health Perspect. 2006] -... - 0 views
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The results suggest that elderly men with MetS were more susceptible to autonomic dysfunction in association with chronic lead exposure as measured in patella. The modification by MetS is consistent with a role for oxidative stress in lead toxicity on the cardiovascular system.
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Depressed thyroid indexes associated with occupati... [Arch Intern Med. 1983] - PubMed ... - 0 views
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the association between low thyroid indexes and elevated lead levels merits attention because of the large number of workers exposed to lead and the similarities between the clinical features of adult lead poisoning and hypothyroidism.
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ScienceDirect - Environmental Research : The effect of long-term low-dose lead exposure... - 0 views
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his study revealed that long-term low-level lead exposure may lead to reduced FT4 level without significant changes in TSH and T3 levels in adolescents even at low Pb-B levels.
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[Effects of lead on thyroid function of occupation... [Zhonghua Lao Dong Wei Sheng Zhi ... - 0 views
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e workers with higher level of blood lead (> 2.88 micro mol/L) showed lower levels of T(3) [(1.54 +/- 0.39) nmol/L] and FT(3)
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Higher level of blood lead may cause certain damage to thyroid function by inhibiting deiodination of T(4)
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Lead toxicity and chelation therapy - 0 views
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Conditions Causing Type 2 Diabetes And High BP : Study - 0 views
www.pharmacy.biz/abetes-and-high-blood-pressure
pharmacy-business Prevalence-of-hypertension-in-type-2-diabetes Type-2-diabetes-and-hypertension-treatment Type-1-diabetes-and-hypertension Hypertension-and-diabetes
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A study by scientists in a UK university has shown the scale of the prevalence of a condition that can lead to various cardiometabolic diseases. The study published in the Annals of Internal Medicine journal on Tuesday (January 4) has prompted calls for changes to healthcare policy after researchers revealed, for the first time, the scale of the impact of the condition associated with benign tumours that can lead to type 2 diabetes and high blood pressure. Up to 10 per cent of adults have a benign tumour, or lump, known as an 'adrenal incidentaloma' in their adrenal glands which can be associated with the overproduction of hormones including the stress steroid hormone cortisol that can lead to type 2 diabetes and high blood pressure. Previous small studies suggested that one in three adrenal incidentalomas produce excess cortisol, a condition called mild autonomous cortisol secretion (MACS). An international research team led by the University of Birmingham carried out the largest ever prospective study of over 1,305 patients with adrenal incidentalomas to assess their risk of high blood pressure and type 2 diabetes and their cortisol production by comparing patients with and without MACS.
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