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Nathan Goodyear

The development of mitochondrial medicine - 0 views

  • n addition to being a primary cause of disease, mitochondrial DNA mutations and impaired oxidation have now been found to occur as secondary phenomena in aging as well as in age-related degenerative diseases such as Parkinson, Alzheimer, and Huntington diseases, amyotrophic lateral sclerosis and cardiomyopathies, atherosclerosis, and diabetes mellitus.
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    good discussion on primary and secondary mitochondrial diseases.  Aging and age-related disease are the result of secondary mitochondrial dysfunction
Nathan Goodyear

Epidemiology: testosterone and the metabolic syndr... [Int J Impot Res. 2007 Mar-Apr] -... - 0 views

  • testosterone may have a protective role in the development of metabolic syndrome and subsequent diabetes mellitus and cardiovascular disease in aging men
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    low Testosterone as part of therapy in those with metabolic syndrome
Nathan Goodyear

Parenteral nutrition in obstetric patients. [Nutr Clin Pract. 1990] - PubMed result - 0 views

  • Sufficient favorable clinical experience over the last 10 years suggests that PN is a relatively safe and effective method for reversing maternal malnutrition and promoting normal fetal growth and development.
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    IV nutritional therapy shown to be safe 
Nathan Goodyear

[Drug-induced lupus erythematosus and systemic lup... [Przegl Lek. 2007] - PubMed result - 0 views

  • Since that time over 80 medications are known to be responsible for development of the disease.
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    Drug-induced Lupus
Nathan Goodyear

EWG Report || BodyBurden 2 - The Pollution in Newborns - 0 views

  • Tests revealed a total of 287 chemicals in the group.
  • Of the 287 chemicals we detected in umbilical cord blood, we know that 180 cause cancer in humans or animals, 217 are toxic to the brain and nervous system, and 208 cause birth defects or abnormal development in animal tests
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    Body Burden - The Pollution in Newborns
Nathan Goodyear

The relationship between testosterone and molecula... [J Endocrinol Invest. 2005] - Pub... - 0 views

  • close relationship exists between the development of a pro-inflammatory state and the decline in T levels
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    inflammation and low testosterone
Nathan Goodyear

Lasting neuropathological changes in rat brain aft... [Folia Neuropathol. 2010] - PubMe... - 0 views

  • Thimerosal, an organomercurial
  • Numerous neuropathological changes were observed in young adult rats which were treated postnatally with thimerosal
  • hese findings document neurotoxic effects of thimerosal, at doses equivalent to those used in infant vaccines or higher, in developing rat brain, suggesting likely involvement of this mercurial in neurodevelopmental disorders.
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    Mercury from thimerosal shown to have serious neuopathological changes in the brain
Nathan Goodyear

SpringerLink - Neurotoxicity Research, Volume 15, Number 1 - 0 views

  • myloid plaques and microgliosis in the brain of Alzheimer’s mice fed with GSE were also reduced by 49% and 70%, respectively
  • Curcumin also significantly reduced brain Aβ burden and microglia activation
  • polyphenol-rich GSE prevents the Aβ deposition and attenuates the inflammation in the brain of a transgenic mouse model, and this thus is promising in delaying development of AD.
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    Grape seed extract and curcumin shown to reduce amyloid plaques and reduce inflammation in the brain: promising treatment in Alzheimers disease
Nathan Goodyear

The mineral selenium proves itself as powerful anti-cancer medicine - 0 views

  • In a December 1996 article in the Journal of the American Medical Association, Dr. Larry Clark presented evidence that supplemental selenium could reduce cancer death rates by as much as 50%
  • patients receiving selenium had a 67% decrease in cancer of the prostate, a 58 percent decrease in colon or rectal cancer and a 45% decrease in lung cancer
  • An article in the Journal of the American Medical Association (JAMA) by Clark et al. (1996) showed that 200 mcg of supplemental selenium a day reduced overall cancer mortality by 50% in humans compared to a placebo group not receiving supplemental selenium
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  • In a recent five-year study of nearly 30,000 rural Chinese people, researchers from the NCI found that daily doses of these three nutrients reduced cancer deaths by 13%.
  • In a study in Cancer Letters (Evangelou et al. 1997), animals with malignant tumors given high doses of vitamins C and E and selenium manifested a significant prolongation of the mean survival time. Complete remission of tumors developed in 16.8% of the animals
  • cities and states with high selenium content in the soil also had significantly lower rates of cancer, especially of the digestive and urinary systems.
  • In one study of hundreds of men, a daily intake of 200 micrograms of selenium cut the incidence of prostate cancer by 60 percent.
  • The statistics for breast cancer are particularly striking. "The higher the selenium, the lower the breast cancer
  • In Yugoslavia, scientists studied 33 patients with breast cancer. These women had selenium levels in their bloodstream only half those of healthy volunteers.
  • The overall reduction in cancer incidence was 37% in the selenium-supplemented group; a 50% reduction in cancer mortality was observed over a 10-year period
  • The following are the site-specific reductions in cancer incidence observed in the study: colon-rectal cancers (58%), lung cancer (46%), and prostate cancer (63%)
  • A selenium deficiency appears to increase the risk of prostate cancer fourfold to fivefold
  • It was determined that, as the male population ages, selenium levels decrease, paralleling an increase in prostate cancer
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    exhaustive discussion selenium deficiency and increased cancer risk
Nathan Goodyear

Vitamin D intake and incidence of multiple scleros... [Neurology. 2004] - PubMed result - 0 views

  • a protective effect of vitamin D intake on risk of developing MS.
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    vitamin D intake protects against risk of MS
Nathan Goodyear

The major green tea polyphenol, (-)-epigallocatech... [J Nutr. 2008] - PubMed result - 0 views

  • Our results indicate that long-term EGCG treatment attenuated the development of obesity, symptoms associated with the metabolic syndrome, and fatty liver. Short-term EGCG treatment appeared to reverse preexisting high-fat-induced metabolic pathologies in obese mice. These effects may be mediated by decreased lipid absorption, decreased inflammation, and other mechanisms.
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    Green tea extract results in weight loss, both short-term and long-term
Nathan Goodyear

New Developments and Novel Therapeutic Perspectives for Vitamin C - 0 views

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    Fascinating article on IV vitamin C and the biochemical implications of therapy in Cancer and Cardiovascular disease treatment
Nathan Goodyear

Do urinary oestrogen metabolites predict breast ca... [Br J Cancer. 1998] - PubMed result - 0 views

  • post-menopausal (but not premenopausal) women at baseline who went on to develop breast cancer showed about a 15% lower 2:16alpha-OHE1 ratio than matched control subjects
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    can the pathway of estrogen metabolism help to predict postmenopausal breast cancer?  according to this study, yes.
Nathan Goodyear

Wiley Online Library: Book Abstract - 0 views

  • In the relatively uncommon circumstance of vaccine matching the viral circulating strain and high circulation, 4% of unvaccinated people versus 1% of vaccinated people developed influenza symptoms (risk difference (RD) 3%
  • The corresponding figures for poor vaccine matching were 2% and 1% (RD 1, 95% CI 0% to 3%).
  • Vaccination had a modest effect on time off work and had no effect on hospital admissions or complication rates
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  • Influenza vaccines have a modest effect in reducing influenza symptoms and working days lost. There is no evidence that they affect complications, such as pneumonia, or transmission.
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    exhaustive review of the flu vaccine data reveals VERY poor matching of vaccine, poor prevention of flu symptoms, and only modest effect on reduction in hospital admission or complication rates.   Final conclusion: "There is no evidence that they affect complications, such as pneumonia, or TRANSMISSION.
Nathan Goodyear

Association of nonalcoholic fatty liver disease with insulin resistance - 0 views

  • Nonalcoholic fatty liver disease is associated with insulin resistance and hyperinsulinemia
  • educe insulin sensitivity and increase serum triglyceride levels may be responsible for its development.
  • Genetic factors that
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    Insulin resistance and fatty liver
Nathan Goodyear

Effects of endocrine disruptors on obesity. [Int J Androl. 2008] - PubMed result - 0 views

  • Most recently, obesity has been proposed to be yet another adverse health effect of exposure to endocrine disrupting chemicals (EDCs) during critical stages of development. Obesity is quickly becoming a significant human health crisis
  • The emerging idea of an association of EDCs and obesity expands the focus on obesity from intervention and treatment to include prevention and avoidance of these chemical modifiers.
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    Effects of endocrine disruptors on obesity.
Nathan Goodyear

Developmental exposure to endocrine disruptors and... [Reprod Toxicol. 2007 Apr-May] - ... - 0 views

  • e review the literature that proposes an association of exposure to environmental endocrine disrupting chemicals with the development of obesity
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    exposure to toxins perinatally likely playing a significant role in the run-away-train obesity epidemic over last 3 decades
Nathan Goodyear

Toxic environment and obesity pandemia: is there a... [Ital J Pediatr. 2010] - PubMed r... - 0 views

  • Recent cumulating evidence suggests that obesity may represent an adverse health consequence of exposure during the critical developmental windows to environmental chemicals disrupting endocrine function. Moreover, exposure to these chemicals seems to play a key role in the development of obesity-related metabolic and cardiovascular diseases.
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    Toxic environment and obesity
Nathan Goodyear

Sudden cardiac death secondary to antidepressant and antipsychotic drugs - 0 views

  • Sudden cardiac death secondary to antidepressant and antipsychotic drugs
  • This review examines the mechanisms and predisposing factors underlying the development of cardiac arrhythmias, and sudden cardiac death, associated with antidepressant and antipsychotic drugs in clinical use.
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    Sudden cardiac death secondary to antidepressant and antipsychotic drugs
Nathan Goodyear

Metabolic biomarkers of increased oxidative stress... [Am J Clin Nutr. 2004] - PubMed r... - 0 views

  • children with autism had significantly lower baseline plasma concentrations of methionine, SAM, homocysteine, cystathionine, cysteine, and total glutathione and significantly higher concentrations of SAH, adenosine, and oxidized glutathione
  • This metabolic profile is consistent with impaired capacity for methylation (significantly lower ratio of SAM to SAH) and increased oxidative stress (significantly lower redox ratio of reduced glutathione to oxidized glutathione) in children with autism
  • increased vulnerability to oxidative stress and a decreased capacity for methylation may contribute to the development and clinical manifestation of autism.
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    detoxification impairment and the markers to assess it in children with ASD
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