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Nathan Goodyear

Vitamin C at high concentrations induces cytotoxicity in malignant melanoma but promote... - 0 views

onlinelibrary.wiley.com/...mc.22654

melanoma vitamin C

shared by Nathan Goodyear on 20 Aug 19 - No Cached
  • Nathan Goodyear on 20 Aug 19
     
    vitamin C at low concentrations promoted cell growth, migration and cell cycle progression, and protected against mitochondrial stress; but vitamin C at high concentrations inhibited cell growth, promoted apoptosis, inhibited metastasis and was adjunctive with vemurafenib.
Nathan Goodyear

Frontiers | Low Concentrations of Vitamin C Reduce the Synthesis of Extracellular Polym... - 0 views

www.frontiersin.org/...full

biofilm vitamin C

shared by Nathan Goodyear on 05 Sep 19 - No Cached
  • Nathan Goodyear on 05 Sep 19
     
    Study finds that vitamin C reduces bacterial biofilm then increasing susceptibility to the pro-oxidative effects of vitamin C and the antibacterial effects of antibiotics.
Nathan Goodyear

Therapeutic hyperthermia: The old, the new, and the upcoming - Critical Reviews in Onco... - 1 views

www.croh-online.com/...fulltext

hyperthermia hyperthermic therapy cancer oncology

shared by Nathan Goodyear on 30 Aug 18 - No Cached
  • not well understood, but it is felt to be a combination of both heat-induced necrosis and of protein inactivation (e.g., repair enzymes) as opposed to DNA damage
  • alterations in tumor cytoskeletal and membrane structures, which disrupt cell motility and intracellular signal transduction
  • A common explanation for HT-enhancement of RT and CT involves inhibition of homologous recombination repair of double-strand DNA breaks, preventing cells from repairing sub-lethal damage
  • ...15 more annotations...
  • it does appear to inhibit rejoining of RT-induced DNA breaks more than is commonly observed after RT alone
  • HT damages cells and enhances RT and CT sensitivity as a function of both temperature and duration of treatment
  • as temperature or duration increase, the rate of cell killing also increases
  • At temperatures above 42 °C, tumor vasculature is damaged, resulting in decreased blood flow
  • Cancer cells are particularly vulnerable to heating; in vivo studies have shown that temperatures in the range of 40–44 °C cause more selective damage to tumor cells
  • cancerous blood vessels are chaotic, leaky, and inefficient
  • selective cytotoxic effect on tumor cells include inhibition of key cancer cell-signaling pathways such as AKT, inducing apoptosis, suppression of cancer stem cell proliferation, and others
  • increase in immunological attacks against tumors after HT, which were believed to be achieved through activation of HSPs and subsequent modulation of the innate and adaptive immune responses against tumor cells
  • HT does lead to activation of the immune system and HSP-induced cell death through modification of the tumor cell surface
  • These HSPs and tumor antigens are taken up by dendritic cells and macrophages and go on to induce specific anti-tumor immunity
  • In vivo studies demonstrate HT-enhancement of NK cell activity, and HT has been shown to increase neutrophilic granulocytes with anti-tumor activity
  • it has become increasingly clear that HT results in immune stimulation, through both direct heat-mediated cell killing as well as innate and adaptive immune system modulation
  • The term hyperthermia is used in this review to refer to heating within the clinically accepted range of 40–45 °C
  • temperatures above 42.5–43 °C the exposure time can be halved with each 1 °C increase while maintaining equivalent cell killing
  • gradual heating at 43 °C for 1 h worked through an apoptotic pathway
  • Nathan Goodyear on 30 Aug 18
     
    Comprehensive review of hyperthemic therapy.
Nathan Goodyear

Ascorbic acid (vitamin C) effects on withdrawal syndrome of heroin abusers. - PubMed - ... - 0 views

www.ncbi.nlm.nih.gov/...10836211

vitamin c heroin ascorbic acid

shared by Nathan Goodyear on 29 Jun 17 - No Cached
  • Nathan Goodyear on 29 Jun 17
     
    Vitamin C effective in reducing heroin withdrawal symptoms.  this is only with oral dosing.  I would anticipate even better results with IV vitamin C.
Nathan Goodyear

Ascorbate regulates haematopoietic stem cell function and leukaemogenesis : Nature : Na... - 0 views

www.nature.com/...nature23876.html

leukemia cancer vitamin c IV vitamin c Tet2

shared by Nathan Goodyear on 23 Oct 17 - No Cached
  • Nathan Goodyear on 23 Oct 17
     
    Low vitamin C levels accelerate the initiation of leukemia. High dose vitamin C found to accumulate and promote Tet2 activity in haematopoietic stem cells, thereby  decreasing initiation and progression of leukemia.
Nathan Goodyear

Improved liver function after high dose intravenous vitamin C and Helxior SC injections... - 0 views

www.researchgate.net/...chemotherapy-and-radiation.pdf

metastasis high dose vitamin C IV vitamin C High dose IV vitamin C hepatocellular carcinoma cancer hepatocellular cancer vitamin C

shared by Nathan Goodyear on 09 Mar 21 - No Cached
  • Nathan Goodyear on 09 Mar 21
     
    HDIVC plus mistletoe SQ improved and stabilized a patient with advanced hepatocellular carcinoma.
Nathan Goodyear

Impact of high dose vitamin C on platelet function - 0 views

www.ncbi.nlm.nih.gov/...PMC5295168

vitamin C platelets High dose IV vitamin C high dose vitamin C

shared by Nathan Goodyear on 22 Nov 21 - No Cached
  • Nathan Goodyear on 22 Nov 21
     
    High dose vitamin C decreases platelet agglutination.
Nathan Goodyear

Frontiers | Vitamin C Administration by Intravenous Infusion Increases Tumor Ascorbate ... - 0 views

www.frontiersin.org/...full

vitamin C ascorbic acid tumor surgery HIF-1alpha cancer HIF-1 HIF-1α RBC ascorbic acid

shared by Nathan Goodyear on 29 Jun 22 - No Cached
  • Nathan Goodyear on 29 Jun 22
     
    Vitamin C found to increase tumor concentration of vitamin C over control.
Nathan Goodyear

Selenium modulates cancer cell response to pharmacologic ascorbate - PubMed - 0 views

pubmed.ncbi.nlm.nih.gov/35916672

IV vitamin C vitamin C cancer High dose IV vitamin C high dose vitamin C selenium

shared by Nathan Goodyear on 03 Sep 22 - No Cached
  • Nathan Goodyear on 03 Sep 22
     
    We dwficiency increases vitamin c cytotoxicity
Nathan Goodyear

Vitamin C for Sepsis and Septic Shock - PubMed - 0 views

pubmed.ncbi.nlm.nih.gov/34264892

vitamin C septic shock sepsis

shared by Nathan Goodyear on 07 Jun 22 - No Cached
  • Nathan Goodyear on 07 Jun 22
     
    Review article on vitamin C in the treatment of sepsis and septic shock. The most common dose is 1.5 gram Q6 is inadequate secondary to all the constraints on vitamin C, i.e., 1/2 life, metabolic demands, deficiency, weight, inflammation…A one size fits all approach never WORKS!
Nathan Goodyear

Effect of high-dose intravenous vitamin C on inflammation in cancer patients - 0 views

www.translational-medicine.com/...1479-5876-10-189.pdf

IV vitamin C IV intravenous vitamin C antioxidant antioxidants inflammation IL-1 IL-2 IL-8 TNF-alpha CRP cytokines

shared by Nathan Goodyear on 10 Dec 12 - No Cached
  • Nathan Goodyear on 10 Dec 12
     
    In this small study, IV vitamin C up to 50 grams shown to reduce inflammation in cancer patients. The inflammatory cytokines reduced were: IL-1alpha, crp, IL-2, IL-8, and TNF-alpha.
Nathan Goodyear

Vitamin C Can Kill Multidrug-Resistant TB in the Lab - 0 views

www.lef.org/...LefDailyNews.htm

vitamin C vitamin C

shared by Nathan Goodyear on 28 May 13 - No Cached
  • Nathan Goodyear on 28 May 13
     
    Vitamin C shown to be bactericidal to multi-drug resistant TB in vitro.  Whether in vivo studies duplicate this or not remains to be seen, but I would anticipate it will.
Nathan Goodyear

Rethinking vitamin C and cancer: an update on nutritional oncology - 0 views

www.riordanclinic.org/...89019191.pdf

IV IV vitamin C vitamin C intravenous cancer cytotoxic

shared by Nathan Goodyear on 29 May 13 - No Cached
  • Nathan Goodyear on 29 May 13
     
    1998 article that looks at the cytotoxic effects of vitamin C on cancer cells.
Nathan Goodyear

Intravenous Ascorbic Acid: protocol for its application and use - 0 views

www.riordanclinic.org/...89022715.pdf

IVC vitamin C IV vitamin C intravenous infusion rate vitamin C infusion rate IV infusion rate

shared by Nathan Goodyear on 29 May 13 - No Cached
  • Nathan Goodyear on 29 May 13
     
    Nice review of the use and dosing of IV vitamin C therapy.
Nathan Goodyear

Autoimmune disease and allergy are controlle... [In Vivo. 1994 Mar-Apr] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...7919130

autoimmune disease allergy IV vitamin C vitamin C intravenous intravenous vitamin C

shared by Nathan Goodyear on 02 Jun 13 - No Cached
  • Nathan Goodyear on 02 Jun 13
     
    IV Vitamin C treatment lowers inflammation in those with autoimmune disease and allergies.  This response is, however, short lived.
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