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Meta-analysis of double blind randomized controlled clinical trials of acetyl-L-carniti... - 0 views

www.crd.york.ac.uk/...ShowRecord.asp Acetyl-L-carnitine acetyl Carnitine cognition cognitive decline brain alzheimer disease
shared by Nathan Goodyear on 04 Nov 13 - No Cached
  • Nathan Goodyear on 04 Nov 13
     
    Meta-analysis of 21 studies on acetyl Carnitine finds improvement with mild cognitive impairment and/or prevention of cognitive deterioration.
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Acetyl-L-carnitine treatment increases choline ace... [Brain Res. 1994] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...8137174 Acetyl-L-carnitine carnitine brain acetylcholine nerve growth factor
shared by Nathan Goodyear on 04 Nov 13 - No Cached
  • Nathan Goodyear on 04 Nov 13
     
    Rat study, but acetyl-L-carnitine shown to increase nerve growth factor.  In addition, it increased acetylcholine activity.
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Oral acetyl-l-carnitine therapy reduces fatigue in overt hepatic encephalopathy: a rand... - 0 views

www.ajcn.org/...799.abstract Acetyl-L-carnitine fatigue
shared by Nathan Goodyear on 24 May 11 - No Cached
  • decrease in the severity of both mental and physical fatigue and an increase in physical activity
  • Nathan Goodyear on 24 May 11
     
    Acetyl-L-carnitine reduces fatigue
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L-acetylcarnitine causes rapid antidepressant effects through the epigenetic induction ... - 0 views

www.ncbi.nlm.nih.gov/...PMC3607061 carnitine L-Carnitine Acetyl-L-carnitine depression
shared by Nathan Goodyear on 03 Nov 13 - No Cached
  • Nathan Goodyear on 03 Nov 13
     
    rat model finds fast, long-lasting benefit of acetyl carnitine in depression.
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Multicentre study of l-alpha-glyceryl-ph... [Drugs Aging. 1993 Mar-Apr] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...8477148 alpha GPC alpha-GPC Acetyl-L-carnitine dementia Alzheimer's disease aging brain
shared by Nathan Goodyear on 27 Aug 14 - No Cached
  • Nathan Goodyear on 27 Aug 14
     
    alpha-GPC and to a lesser degree acetyl-l-carnitine improved dementia in multi-center trial.
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Long-term stabilization of stage 4 colon cancer using sodium dichloroacetate therapy - 1 views

www.ncbi.nlm.nih.gov/...PMC5067498 DCA dichloroacetate dichloracetic acid cancer colon cancer
shared by Nathan Goodyear on 18 Jan 18 - No Cached
  • inhibition of mitochondrial pyruvate dehydrogenase kinase
  • inhibition of aerobic glycolysis (the Warburg effect) and activation of mitochondrial potassium ion channels
  • angiogenesis blockade
  • ...5 more annotations...
  • changes in expression of HIF1-α
  • alteration of pH regulators V-ATPase and MCT1, and other cell survival regulators such as PUMA, GLUT1, Bcl2 and p53
  • DCA as a cancer stabilizing agent
  • A protocol of natural medications was developed to address the dose-limiting neurologic toxicity, in collaboration with a naturopathic physician (Andrews). The oral DCA regimen that was developed included three natural medications acetyl L-carnitine[29-31], R-alpha lipoic acid[32-34] and benfotiamine[35-37], for the primary purpose of neuropathy prevention
  • measurable benefits from DCA therapy in 60%-70% of cases
  • Nathan Goodyear on 18 Jan 18
     
    Good review of dichloracetate or DCA in antitumor activity.  DCA has been shown to have numerous anticancer properties.
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