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Nathan Goodyear

Think Twice: How the Gut's "Second Brain" Influences Mood and Well-Being: Scientific Am... - 0 views

www.scientificamerican.com/article.cfm

gut second brain wellness health well-being mood

shared by Nathan Goodyear on 24 Aug 11 - No Cached
  • Nathan Goodyear on 24 Aug 11
     
    So goes your gut, so goes your brain and mood
Well365 living

Discover Helpful Products for Wellness at WELL365 - 0 views

vimeo.com/user125297435

WELL365 reviews WELL 365 Waistbuster

shared by Well365 living on 03 Mar 22 - No Cached
  • Well365 living on 03 Mar 22
     
    Purchase an amazing range of wellness products from Well365 like Painbuster for a pain reliever, Super MIC B12, and Waistbuster for Weight loss. To check out Well365 Reviews visit https://well365living.com/
Nathan Goodyear

A Natural Product Telomerase Activator Lengthens Telomeres in Humans: A Randomized, Dou... - 0 views

online.liebertpub.com/...rej.2015.1793

TA-65 Telomerase telomerase activator Telomeres aging wellness health natural

shared by Nathan Goodyear on 16 May 16 - No Cached
  • Nathan Goodyear on 16 May 16
     
    low dose TA-65, which is a telomerase activator found to significantly lengthen Telomeres in human randomized study.
Nathan Goodyear

A Natural Product Telomerase Activator As Part of a Health Maintenance Program - 0 views

www.ncbi.nlm.nih.gov/...PMC3045570

TA-65 natural telomere Telomerase telomerase activator aging wellness health

shared by Nathan Goodyear on 16 May 16 - No Cached
  • Nathan Goodyear on 16 May 16
     
    TA-65, from astragalus, shown to up regulate telomerase activity to increase telomere length to a statistical level.
Nathan Goodyear

Cells | Free Full-Text | Functional Assessment of Pharmacological Telomerase Activators... - 0 views

www.mdpi.com/htm

TA-65 telomere Telomerase telomerase activator natural aging wellness health

shared by Nathan Goodyear on 16 May 16 - No Cached
  • Nathan Goodyear on 16 May 16
     
    Full study of previously posted abstract of TA-65 increase of telomere length in cell culture.
Nathan Goodyear

Cells | Free Full-Text | Functional Assessment of Pharmacological Telomerase Activators... - 0 views

www.mdpi.com/57

TA-65 telomere telomerase activator Telomerase aging natural wellness health

shared by Nathan Goodyear on 16 May 16 - No Cached
  • Nathan Goodyear on 16 May 16
     
    TA-65 found to significantly increase telomerase activity in cell culture.
Nathan Goodyear

The telomerase activator TA-65 elongates short telomeres and increases health span of a... - 0 views

www.ncbi.nlm.nih.gov/...PMC3627294

TA-65 telomere Telomerase telomerase activator aging natural wellness health

shared by Nathan Goodyear on 16 May 16 - No Cached
  • studies have demonstrated that the shortest telomeres are causal of reduced cell viability
  • a stable and enforced expression of telomerase leads to an improved health-span, accompanied by an extension of lifespan
  • TA-65 influences the percentage of cellular short telomeres through the activation of telomerase
  • ...17 more annotations...
  • TA-65 administration during 4 months significantly improved the capacity to uptake glucose after a glucose pulse
  • liver protective action of TA-65
  • A disadvantage of mTERT potentiation could be associated to its capacity to favor proliferation of cancerous cells in murine models
  • TA-65 treated mice presented a similar incidence of malignant cancers at time of death, with a tendency to show decreased sarcomas and slightly increased lymphomas
  • We demonstrate here that TA-65 leads to a significant rescue of short telomeres through telomerase activation
  • TA-65 treatment increases proliferation and mobilization potential of mouse keratinocytes in vitro, a situation mimicking telomerase overexpression
  • TAT2, a similar molecule, have beneficial effects in the activation of CD8+ T lymphocytes from HIV-infected patients where they observe an increase of the proliferative potential and enhancement of cytokine/chemokine production
  • TA-65 resulted in a similar rescue of short telomeres in leukocytes post-treatment as observed with humans, most likely through an activation of telomerase
  • we observe that TA-65 lead to 10 fold increase of telomerase RNA levels in the liver of treated mice comparing to the non-treated same-age cohorts
  • TA-65 regulates telomerase at the transcription level, probably through the regulation of the MAPK pathway
  • TA-65 dependent telomerase activation results in a better organ fitness as demonstrated by the improved scores at the glucose tolerance test and insulin levels at fasting
  • TA-65 supplemented mice also present modest enhancement of the subcutaneous and epidermal thickness, as well as higher bone density, representative of an overall fitness status improvemen
  • TA-65 treated mice present higher levels of RBC and hemoglobin comparing to the control cohorts
  • improved health-span of TA-65 treated mice is not accompanied by increased cancer incidence, which may be related to the fact that TERT levels are very modestly increased in all tissues tested except for the liver
  • systemic telomerase overexpression from the germline leads to protection from aging associated pathologies
  • similar situation could be mimicked expressing telomerase late in life in a telomerase deficient background
  • we observed a higher proliferation rate and a partial protection from cell death in some tissues of TA65 treated mice
  • Nathan Goodyear on 16 May 16
     
    TA-65 shown to increase telomerase activity, and thus telomere length of short telomeres, in mouse study.  
Nathan Goodyear

JAMA Network | JAMA Oncology | The Preventability of Cancer:  Stacking the Deck - 0 views

oncology.jamanetwork.com/article.aspx

cancer lifestyle intervention health wellness

shared by Nathan Goodyear on 23 May 16 - No Cached
  • Nathan Goodyear on 23 May 16
     
    Lifestyle interventions to prevent cancer
Nathan Goodyear

JAMA Network | JAMA Oncology | Preventable Incidence and Mortality of Carcinoma Associa... - 0 views

oncology.jamanetwork.com/article.aspx

lifestyle intervention cancer health wellness

shared by Nathan Goodyear on 23 May 16 - No Cached
  • Nathan Goodyear on 23 May 16
     
    Health lifestyle interventions reduce the incidence and mortality from cancer.
Nathan Goodyear

Association of Animal and Plant Protein Intake With All-Cause and Cause-Specific Mortal... - 0 views

archinte.jamanetwork.com/article.aspx

protein nutrition mortality health wellness

shared by Nathan Goodyear on 08 Aug 16 - No Cached
  • Nathan Goodyear on 08 Aug 16
     
    high red meat protein intake associated with higher mortality rate compared to plant-based protein.
Nathan Goodyear

A Healthy Body in a Healthy Mind-and Vice Versa-The Damaging Power of "Uncontrollable" ... - 0 views

jcem.endojournals.org/...1842.full

stress cortisol cancer health healthy wellness inflammation

shared by Nathan Goodyear on 28 Nov 11 - No Cached
  • Nathan Goodyear on 28 Nov 11
     
    very nice article on how stress causes inflammation and creates an unhealthy environment and thus a breeding ground for disease
Nathan Goodyear

http://www.plosone.org/article/fetchObject.action?uri=info:doi/10.1371/journal.pone.008... - 0 views

www.plosone.org/...fetchObject.action

nutrition diet vegetarian vegan health wellness

shared by Nathan Goodyear on 02 Apr 14 - No Cached
  • Nathan Goodyear on 02 Apr 14
     
    to be read
Nathan Goodyear

Testosterone Deficiency, Cardiac Health, and Older Men - 0 views

www.hindawi.com/...143763

low T Testosterone obesity type II diabetes diabetes health wellness metabolic syndrome lipids cholesterol hypogonadism TDS testicular dysgenesis syndrome men male hormone hormones prostate cancer

shared by Nathan Goodyear on 12 May 14 - No Cached
  • Studies have shown pharmacological doses of testosterone to relax coronary arteries when injected intraluminally [39] and to produce modest but consistent improvement in exercise-induced angina and reverse associated ECG changes [40]. The mechanism of action is via blockade of calcium channels with effect of similar magnitude to nifedipine
    • Nathan Goodyear
      Nathan Goodyear on 12 May 14
       
      This directly refutes the recent studies (3) that Testosterone therapy increases cardiovascular events.
    • Nathan Goodyear
      Nathan Goodyear on 13 May 14
       
      Testosterone acts as a calcium channel blocker inducing vasodilation.
  • men with chronic stable angina pectoris, the ischaemic threshold increased after 4 weeks of TRT and a recent study demonstrates improvement continuing beyond 12 months [
  • Exercise capacity in men with chronic heart failure increased after 12 weeks
  • ...36 more annotations...
  • Studies have shown an inverse relationship between serum testosterone and fasting blood glucose and insulin levels
  • Medications such as chronic analgesics, anticonvulsants, 5ARIs, and androgen ablation therapy are associated with increased risk of testosterone deficiency and insulin resistance
  • Women with T2D or metabolic syndrome characteristically have low SHBG and high free testosterone
    • Nathan Goodyear
      Nathan Goodyear on 12 May 14
       
      This stands in polar opposite of that with men.
  • Hypogonadism is a common feature of the metabolic syndrome
  • The precise interaction between insulin resistance, visceral adiposity, and hypogonadism is, as yet, unclear but the important mechanisms are through increased aromatase production, raised leptin levels, and increase in inflammatory kinins
  • levels of testosterone are reduced in proportion to degree of obesity
  • Men should be encouraged to combine aerobic exercise with strength training. As muscle increases, glucose will be burned more efficiently and insulin levels will fall. A minimum of 30 minutes exercise three times weekly should be advised
  • Testosterone increases levels of fast-twitch muscle fibres
  • By increasing testosterone, levels of type 2 fibres increase and glucose burning improves
  • Weight loss will increase levels of testosterone
  • studies now clearly show that low testosterone leads to visceral obesity and metabolic syndrome and is also a consequence of obesity
  • In the case of MMAS [43], a baseline total testosterone of less than 10.4 nmol/L was associated with a greater than 4-fold incidence of type 2 diabetes over the next 9 years
  • There is high level evidence that TRT improves insulin resistance
  • Low testosterone predicts increased mortality and testosterone therapy improves survival in 587 men with type 2 diabetes
  • A similar retrospective US study involved 1031 men with 372 on TRT. The cumulative mortality was 21% in the untreated group versus 10% ( ) in the treated group with the greatest effect in younger men and those with type 2 diabetes
  • the presence of ED has been shown to be an independent risk factor, particularly in hypogonadal men, increasing the risk of cardiac events by over 50%
  • A recent online publication on ischaemic heart disease mortality in men concluded optimal androgen levels are a biomarker for survival
  • inverse associations between low TT or FT (Table 2) and the severity of CAD
  • A recent 10 year study from Western Australia involving 3690 men followed up from 2001–2010 concluded that TT and FT levels in the normal range were associated with decreased all-cause and cardiovascular mortality, for the first time suggesting that both low and DHT are associated with all-cause mortality and higher levels of DHT reduced cardiovascular risk
  • TDS is associated with increased cardiovascular and all-cause mortality
  • The effect of treatment with TRT reduced the mortality rate of treated cohort (8.4%) to that of the eugonadal group whereas the mortality for the untreated remained high at 19.2%
  • hypogonadal men had slightly increased triglycerides and HDL
  • Men with angiographically proven CAD (coronary artery disease) have significantly lower testosterone levels [29] compared to controls ( ) and there was a significant inverse relationship between the degree of CAD and TT (total testosterone) levels
  • TRT has also been shown to reduce fibrinogen to levels similar to fibrates
  • men treated with long acting testosterone showed highly significant reductions in TC, LDL, and triglycerides with increase in HDL, associated with significant reduction in weight, BMI, and visceral fat
  • Low androgen levels are associated with an increase in inflammatory markers
  • In the Moscow study, C-reactive protein was reduced by TRT at 30 weeks versus placebo
  • In some studies, a decline in diastolic blood pressure has been observed, after 3–9 months [24, 26] and in systolic blood pressure
  • A decline was noted in IL6 and TNF-alpha
  • No studies to date show an increase in LUTS/BPH symptoms with higher serum testosterone levels
  • TRT has been shown to upregulate PDE5 [65] and enhance the effect of PDE5Is (now an accepted therapy for both ED and LUTS), it no longer seems logical to advice avoidance of TRT in men with mild to moderate BPH.
    • Nathan Goodyear
      Nathan Goodyear on 12 May 14
       
      What about just starting with normalization of Testosterone levels first.
  • Several meta-analyses have failed to show a link between TRT and development of prostate cancer [66] but some studies have shown a tendency for more aggressive prostate cancer in men with low testosterone
    • Nathan Goodyear
      Nathan Goodyear on 12 May 14
       
      And if one would have looked at their estrogen levels, I guarantee they would have been found to be elevated.
  • low bioavailable testosterone and high SHBG were associated with a 4.9- and 3.2-fold risk of positive biopsy
  • Current EAU, ISSAM, and BSSM guidance [1, 2] is that there is “no evidence TRT is associated with increased risk of prostate cancer or activation of subclinical cancer.”
  • Men with prostate cancer, treated with androgen deprivation, develop an increase of fat mass with an altered lipid profile
  • Erectile dysfunction is an established marker for future cardiovascular risk and the major presenting symptom leading to a diagnosis of low testosterone
Nathan Goodyear

Validity of the ithlete™ Smart Phone Application for Determining Ultra-Short-... - 0 views

www.ncbi.nlm.nih.gov/...PMC3916914

heart rate variability HRV heart health wellness app

shared by Nathan Goodyear on 26 Jun 14 - No Cached
  • Nathan Goodyear on 26 Jun 14
     
    HRV application validated
Nathan Goodyear

Muscle Mass Index As a Predictor of Longevity in Older Adults - The American Journal of... - 0 views

www.amjmed.com/...fulltext

muscle mass mortality exercise health wellness longevity

shared by Nathan Goodyear on 19 Jul 14 - No Cached
  • Nathan Goodyear on 19 Jul 14
     
    Higher muscle mass associated with lower mortality in older adults.  so many focus on cardio and forget about resistance training.
Young Leaf Wellness

How To Steep The Perfect Tea For Full Benefits - 1 views

www.youngleafwellness.com/#!How-To-Steep-The-Perfect-Tea-For-Full-Benefits/c1vuq/55a3743e0cf2ba155ecedc59

Detox Tea Wellness Detox Tea Weight Loss Detox Tea

shared by Young Leaf Wellness on 13 Jul 15 - No Cached
  • Young Leaf Wellness on 13 Jul 15
     
    Tea is enjoyed around the world, but preparing the perfect cup is more than turning the stovetop on high and throwing a tea bag in a cup. Learning to steep the perfect cup isn't as difficult as it may seem.
Nathan Goodyear

Intermittent fasting: a dietary intervention for prevention of diabetes and cardiovascu... - 0 views

dvd.sagepub.com/...68.long

intermittent fasting fasting nutrition CVD diabetes obesity health wellness

shared by Nathan Goodyear on 03 Jul 15 - No Cached
  • Nathan Goodyear on 03 Jul 15
     
    Intermittent fasting can be used as an adjunct for a healthy lifestyle transition in those with obesity, diabetes, and increased risk of CVD.
Nathan Goodyear

A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognit... - 0 views

www.cell.com/...S1550-4131(15)00224-7

intermittent fasting disease health wellness aging diabetes CVD cancer metabolism fasting

shared by Nathan Goodyear on 03 Jul 15 - No Cached
  • Nathan Goodyear on 03 Jul 15
     
    Intermittent fasting decreased biomarkers for aging, diabetes, CVD, and cancer.
Nathan Goodyear

What's the Hard Return on Employee Wellness Programs? - Harvard Business Review - 0 views

hbr.org/...1

wellness corporate

shared by Nathan Goodyear on 03 Dec 10 - No Cached
  • Nathan Goodyear on 03 Dec 10
     
    corporate wellness saves money
Nathan Goodyear

MinnPost - Wellness company RedBrick Health links success to health care social media - 0 views

www.minnpost.com/...ss_to_health_care_social_media

wellness health company

shared by Nathan Goodyear on 18 Feb 11 - No Cached
  • Nathan Goodyear on 18 Feb 11
     
    interesting read
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