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Nathan Goodyear

Mary Ann Liebert, Inc. - Diabetes Technology & Therapeutics - 2(3):401 - 0 views

www.liebertonline.com/...15209150050194279

alpha-lipoic-acid insulin sensitivity resistance Type II Diabetes DM

shared by Nathan Goodyear on 03 Sep 11 - No Cached
  • Nathan Goodyear on 03 Sep 11
     
    alpha lipoic acid improves insulin sensitivity in patients with type II Diabetes
Nathan Goodyear

Effect of Nigella sativa seeds on the glycemic con... [Indian J Physiol Pharmacol. 2010... - 0 views

www.ncbi.nlm.nih.gov/...21675032

Nigella Sativa herb herbs spice diabetes DM

shared by Nathan Goodyear on 17 Aug 11 - No Cached
  • Nathan Goodyear on 17 Aug 11
     
    Nigella sativa, spice, shown to improve blood sugar control in Type II Diabetes
Nathan Goodyear

Mechanisms of Pancreatic β-Cell Death in Type 1 and Type 2 Diabetes - 0 views

diabetes.diabetesjournals.org/...S97.full

diabetes type II diabetes DM insulin pancreas inflammation cytokines metabolic endotoxemia

shared by Nathan Goodyear on 15 Jan 13 - No Cached
  • Nathan Goodyear on 15 Jan 13
     
    inflammation leads to death of pancreatic beta cells and result in diabetes.
Nathan Goodyear

JAMA Network | JAMA | Melatonin Secretion and the Incidence of Type 2 DiabetesMelatonin... - 0 views

jama.jamanetwork.com/article.aspx

melatonin diabetes type II diabetes DM

shared by Nathan Goodyear on 09 Apr 13 - No Cached
  • Nathan Goodyear on 09 Apr 13
     
    lower melatonin secretion linked to increased diabetes risk
Nathan Goodyear

Testosterone, the male hormone connection: treating diabetes and heart disease. - 0 views

www.worldhealth.net/...thera6_ch7.pdf

testosterone low T low testosterone CVD cardiovascular disease diabetes insulin leptin ghrelin PAI-1 obesity adiponectin type II diabetes DM atherosclerosis

shared by Nathan Goodyear on 13 Nov 12 - No Cached
  • Nathan Goodyear on 13 Nov 12
     
    good, well referenced discussion of how Testosterone support for those with low T can improve Diabetes, insulin function, improve energy balance, and reduce cardiovascular disease risk. The discussion discusses many of the moving parts in how testosterone improves CVD risk.
Nathan Goodyear

Cytokines in the Progression of Pancreatic β-Cell Dysfunction - 0 views

www.hindawi.com/...515136

inflammation cytokines inflammatory pancreas DM diabetes type II diabetes metabolic endotoxemia

shared by Nathan Goodyear on 15 Jan 13 - No Cached
  • Nathan Goodyear on 15 Jan 13
     
    inflammatory cytokines lead to progressive pancreatic Beta islet cells dysfunction and resultant diabetes.
Nathan Goodyear

Testosterone Concentrations in Women and Men With NIDDM - 1 views

care.diabetesjournals.org/...405.short

testosterone T men women insulin resistance IR type II DM diabetes

shared by Nathan Goodyear on 11 Feb 12 - No Cached
  • Nathan Goodyear on 11 Feb 12
     
    insulin resistance has different effects in men versus women.  In men, insulin resistance is associated with low T in men, but in elevate T in women.
Nathan Goodyear

Nutrigenomic basis of beneficial effects of... [Mol Cell Biochem. 2008] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...18636317

chromium insulin resistance type II DM diabetes

shared by Nathan Goodyear on 31 Aug 12 - No Cached
  • Nathan Goodyear on 31 Aug 12
     
    Chromium improves insulin resistance.
Nathan Goodyear

Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced d... - 0 views

dl-web.dropbox.com/...0DM%2C%20and%20endotoxemia.pdf

bifidobacterium flora LPS metabolic endotoxemia Diabetes DM type II obesity inflammation overweight weight-loss

shared by Nathan Goodyear on 20 Jan 12 - No Cached
  • Nathan Goodyear on 20 Jan 12
     
    decreased bifidobacterium gut flora results in increased absorption of LPS in high fat diets resulting in endotoxemia. This plays a significant role in diabetes
Nathan Goodyear

Obesity - Effects of Lifestyle Changes to Reduce Risks of Diabetes and Associated Cardi... - 0 views

www.nature.com/...oby2009388a.html

obesity Type II Diabetes DM risks lifestyle effects cardiovascular exercise diet modification

shared by Nathan Goodyear on 20 Dec 11 - No Cached
  • Nathan Goodyear on 20 Dec 11
     
    Lifestyle changes are the most effective therapy in Diabetes development.  These include, diet modification, weight loss, and exercise.
Nathan Goodyear

Arch Intern Med -- Abstract: Statin Use and Risk of Diabetes Mellitus in Postmenopausal... - 0 views

archinte.ama-assn.org/...144

Statin statins type II 2 diabetes DM postmenopausal women

shared by Nathan Goodyear on 28 Feb 12 - No Cached
  • Nathan Goodyear on 28 Feb 12
     
    Statin drugs shown to increase risk of Diabetes in postmenopausal women
Nathan Goodyear

A current update on ... [Endocr Metab Immune Disord Drug Targets. 2009] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...19601918

alpha-lipoic-acid type II 2 Diabetes DM

shared by Nathan Goodyear on 03 Sep 11 - No Cached
  • Nathan Goodyear on 03 Sep 11
     
    alpha-lipoic-acid improves diabetes control and reduces complications
Nathan Goodyear

Testosterone and metabolic syndrome Cunningham GR - Asian J Androl - 0 views

www.ajandrology.com/article.asp

Testosterone metabolic syndrome MetS TT total Testosterone SHBG men male hormone hormones Estradiol insulin resistance

shared by Nathan Goodyear on 02 Mar 15 - No Cached
  • The relationship of low testosterone to MetS often is considered to be bidirectional; however, the relationships probably are not direct
  • Many of the components of the MetS are recognized risk factors for the development of cardiovascular disease (CVD)
  • Multiple cross-sectional studies have found low TT and low sex hormone binding globulin (SHBG) levels in Caucasian and African-American men with the MetS, irrespective of age
  • ...20 more annotations...
  • Low TT and SHBG levels also are prevalent in Chinese [7],[8] and Korean [9] men with the MetS
  • Normally 40%-50% of TT is bound to SHBG, so reducing SHBG levels will decrease TT.
  • Hyperinsulinism suppresses SHBG synthesis and secretion by the liver
  • significant increase in SHBG levels occurred after acutely lowering insulin levels in obese men
  • Estradiol levels are increased in men with the MetS, and they are positively correlated with the number of abnormal components of the MetS.
  • Although it is known that estrogen will increase SHBG levels, apparently the hyperinsulinism associated with obesity has a greater effect on SHBG levels
  • Estradiol also can inhibit luteinizing hormone (LH) secretion
  • Inflammatory cytokines are thought to have a direct effect on the pituitary to reduce LH secretion [15] and also a direct effect on Leydig cell secretion of testosterone
  • Low TT Levels have been shown to predict development of the MetS in men with normal BMI
  • Men in the lowest quartiles of serum TT, calculated free testosterone (cFT) and SHBG at baseline had the highest odds ratios for developing the MetS or DM during the 11 years follow-up
  • More recently, investigators conducting population-based studies have reported that only SHBG is associated with future development of the MetS
  • Additional evidence that low TT increases the risk of MetS comes from androgen deprivation treatment of prostate cancer
  • Low TT and low bioavailable testosterone (bT) were each significantly associated with elevated 20 years risk of CVD mortality in an older population in which cause-specific mortality was age, adiposity, and lifestyle-adjusted.
  • combination of low bT and ATP III-defined MetS is associated with increased cardiovascular mortality in men aged 40 years and above
  • in elderly men, testosterone may weakly protect against CVD. Alternatively, low TT may indicate poor general health
  • Muraleedharan and Jones [27] concluded that there is convincing evidence that low T is a biomarker for disease severity and mortality.
  • The evidence that TRT improves insulin sensitivity and glucose control is conflicted
  • It is widely recognized that testosterone treatment can reduce fat mass and increase lean body mass; however, until recently most reports have not been associated with much weight loss
  • Changes in body composition and weight loss are considered potential mechanisms by which testosterone treatment improves insulin sensitivity and glucose control in patients with diabetes. Effects on inflammatory cytokines [38] and changes in oxidative metabolism [39] also have been reported to improve glucose metabolism.
  • Testosterone replacement therapy has been reported to improve some or all of the components of the MetS.
  • Nathan Goodyear on 02 Mar 15
     
    To be read article on Testosterone and Metabolic Syndrome.
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