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Nathan Goodyear

Therapy in the Early Stage: Incretins - 0 views

  • Increased resistance to insulin action in the skeletal muscle and liver associated with enhanced hepatic glucose output and impaired insulin secretion due to a progressive decline of β-cell function are long-recognized core defects
  • in addition, other mechanisms/organs are involved, augmenting the pathological pathways: adipocytes (altered fat metabolism due to insulin resistance), gastrointestinal tract (incretin deficiency and/or resistance), pancreatic α-cells (hyperglucagonemia and increased hepatic sensitivity to glucagon), kidneys (enhanced glucose reabsorption), and central nervous system (insulin resistance)
  • β-cell failure
    • Nathan Goodyear
       
      and studies have shown that a reduction in insulin function will decrease LH production and thus lead to a decrease in Testosterone production in men.
  • ...2 more annotations...
  • Incretins are gut-derived hormones, members of the glucagon superfamily, released in response to nutrient ingestion (mainly glucose and fat)
  • They exert a wide range of effects, including stimulation of pancreatic insulin secretion in a glucose-dependent manner and play an important role in the local gastrointestinal and whole-body physiology
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    good discussion on incretins and their role in glucose homeostasis. 
Nathan Goodyear

The expanding role of incretin-based therapies: how much should we expect? - 0 views

  • The incretins are peptide hormones released from the small intestine during meal absorption that stimulate insulin secretion from pancreatic β-cells and reduce excessive secretion of glucagon by pancreatic α-cells
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    intro to incretins
Nathan Goodyear

Incretin-based therapies: can we achieve glycemic control and cardioprotection? - 0 views

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    Good discussion on the incretin: (Glucagon-like peptide 1 (GLP-1).
Nathan Goodyear

The Role of Incretins in Glucose Homeostasis and Diabetes Treatment - 0 views

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    good review of incretins
Nathan Goodyear

The Role of Incretins in Glucose Homeostasis and Diabetes Treatment - 0 views

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    incretins and glucose homeostasis
Nathan Goodyear

Effects of glucagon-like peptide 1 on appetite and body weight: focus on the CNS - 0 views

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    To be read article on incretins
Nathan Goodyear

The Incretins: GLP-1 Agonists and DPP-4 Inhibitors | Diabetesnet.com - 0 views

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    GLP-1 agonists improve insulin/glucose control
Nathan Goodyear

Biochemical and metabolic mechanisms by which... [J Nutr Biochem. 2012] - PubMed - NCBI - 0 views

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    Whey protein should be a tool in every medical provider to combat obesity and type II Diabetes.  The role? through improved insulin function: by interactions with cholecystokinin, peptide YY, incretins...
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