Group items tagged

"Previous research on rhesus macaques discovered that social rank influenced components of the stress response, brain, and immune system. With gene chip technology for measuring the expression of over 6,000 different genes, Tung, Gilad and colleagues at Yerkes, Emory University, and Johns Hopkins looked for the first time in primates at the effects of social rank on genetic function. Comparing 49 different female monkeys of different rank revealed significant changes in the expression of 987 genes, including 112 genes associated with immune system function. The result fits with data in monkeys where low rank and chronic stress lead to compromised immune function, and, more loosely, with human studies linking low socioeconomic status and high social stress to elevated disease risk."

Theodore Berger and his team at the USC Viterbi School of Engineering's Department of Biomedical Engineering have developed a neural prosthesis for rats that is able to restore their ability to form long-term memories after they had been pharmacologically blocked. In a dramatic demonstration, Berger blocked the ability to rats to form long-term memories by using pharmacological agents to disrupt the neural circuitry that communicates between two subregions of the hippocampus, CA1 and CA3, which interact to create long-term memory, prior research has shown. The rats were unable to remember which lever to pull to gain a reward, or could only remember for 5-10 seconds, when previously they could remember for a long period of time. The researchers then developed an artificial hippocampal system that could duplicate the pattern of interaction between CA3-CA1 interactions. Long-term memory capability returned to the pharmacologically blocked rats when the team activated the electronic device programmed to duplicate the memory-encoding function. The researchers went on to show that if a prosthetic device and its associated electrodes were implanted in animals with a normal, functioning hippocampus, the device could actually strengthen the memory being generated internally in the brain and enhance the memory capability of normal rats. "These integrated experimental modeling studies show for the first time that with sufficient information about the neural coding of memories, a neural prosthesis capable of real-time identification and manipulation of the encoding process can restore and even enhance cognitive mnemonic processes," says the paper. Next steps, according to Berger and Deadwyler, will be attempts to duplicate the rat results in primates (monkeys), with the aim of eventually creating prostheses that might help human victims of Alzheimer's disease, stroke, or injury recover function. Ref.: "A Cortical Neural Prosthesis for Restoring and Enhancing

"We provide novel evidence for the effects of metabolic dysfunctions on brain function using the rat model of metabolic syndrome induced by high fructose intake. * We describe that the deleterious consequences of unhealthy dietary habits can be partially counteracted by dietary supplementation of n-3 fatty acid. * High sugar consumption impaired cognitive abilities and disrupted insulin signalling by engaging molecules associated with energy metabolism and synaptic plasticity; in turn, the presence of docosahexaenoic acid, an n-3 fatty acid, restored metabolic homeostasis. * These findings expand the concept of metabolic syndrome affecting the brain and provide the mechanistic evidence of how dietary habits can interact to regulate brain functions, which can further alter lifelong susceptibility to the metabolic disorders. "

Music, an abstract stimulus, can arouse feelings of euphoria and craving, similar to tangible rewards that involve the striatal dopaminergic system. Using the neurochemical specificity of [11C]raclopride positron emission tomography scanning, combined with psychophysiological measures of autonomic nervous system activity, we found endogenous dopamine release in the striatum at peak emotional arousal during music listening. To examine the time course of dopamine release, we used functional magnetic resonance imaging with the same stimuli and listeners, and found a functional dissociation: the caudate was more involved during the anticipation and the nucleus accumbens was more involved during the experience of peak emotional responses to music. These results indicate that intense pleasure in response to music can lead to dopamine release in the striatal system. Notably, the anticipation of an abstract reward can result in dopamine release in an anatomical pathway distinct from that associated with the peak pleasure itself. Our results help to explain why music is of such high value across all human societies.

GPUGRID.net is a distributed computing infrastructure devoted to biomedical research. Thanks to the contribution of volunteers, GPUGRID scientists can perform molecular simulations to understand the function of proteins in health and disease.

"A team of scientists at Oxford University have printed - yes, printed - what could be the predecessors to usable synthetic human tissue. The researchers released a paper called A Tissue-Like Material, announcing that they created their own version of a 3D printer, saying the current ones on the market couldn't print what they were after, according to PhsyOrg. And what were they after? A protein sack of water that can mold itself into different shapes and perform similar functions to human cells. After developing the printer, the team was able to print out a series of droplets that formed a network of human-like cells that could act like nerves and send electrical signals across the network."

"uBiome is a citizen science project that allows the public access to cutting edge sequencing technology to understand their health through the microbiome. How does the microbiome affect my health? We are all covered in trillions of microbes -- in fact, they outnumber human cells 10:1. The trillions of bacteria live on and in us are collectively called the microbiome. Like the rainforest, the healthy human microbiome is a balanced ecosystem. The correct balance of microbes keeps potential pathogens in check and regulates our immune system. Microbes also perform essential functions such as digesting food and synthesizing vitamins. Studies have also linked the microbiome to human mood and behavior, as well as many gut disorders, eczema, and chronic sinusitis."

Droplet network printer ""We aren't trying to make materials that faithfully resemble tissues, but rather structures that can carry out the functions of tissues," said Professor Hagan Bayley of Oxford University's Department of Chemistry, who led the research. "We've shown that it is possible to create networks of tens of thousands of connected droplets. The droplets can be printed with protein pores to form pathways through the network that mimic nerves and are able to transmit electrical signals from one side of a network to the other.""

"THE GRAPHING CALCULATOR FOR FUNCTIONS, GEOMETRY, ALGEBRA, CALCULUS, STATISTICS AND 3D MATH!"

'The Exoplanet Exploration Program (ExEP) is responsible for implementing NASA's plans for the discovery and understanding of planetary systems around nearby stars. ExEP plays an important function in exoplanet research, by laying out a long-term view of the entire field and charting out a strategic timeline of missions and instruments."

"This section documents CKAN's API, for developers who want to write code that interacts with CKAN sites and their data. CKAN's Action API is a powerful, RPC-style API that exposes all of CKAN's core features to API clients. All of a CKAN website's core functionality (everything you can do with the web interface and more) can be used by external code that calls the CKAN API."

"When the right microorganisms are at work, immune cells involved in the development of autoimmune illnesses like psoriasis, multiple sclerosis and arthritis, can develop anti-inflammatory properties. Scientists at Charité - Universitätsmedizin Berlin and the Institute for Research in Biomedicine, Bellinzona, Switzerland, have now made this discovery. Their work is published in the current issue of the scientific journal Nature*. The scientists were able to prove that particular fungi activate the immune cells involved in the development of certain illnesses, whereas other microorganisms, in particular bacteria that are found naturally on our skin, lend an anti-inflammatory function to them. "This not only demonstrates that the composition of our microflora has a decisive role in the development of chronic illnesses, but also that the key cells causing illness can develop an anti-inflammatory 'twin'," explained Dr. Christina Zielinski, first author of the study."

While a substantial body of work has been devoted to understanding the role of negative stereotypes in racial attitudes, far less is known about how we deal with contradictions of those stereotypes. This article uses functional brain imaging with contextually rich visual stimuli to explore the neural mechanisms that are involved in cognition about social norms and race. We present evidence that racial stereotypes are more about the stereotypes than about race per se. Amygdala activity (correlated with negative racial attitudes in other studies) appeared driven by norm violation, rather than race.

The Encyclopedia of DNA Elements (ENCODE) Consortium is an international collaboration of research groups funded by the National Human Genome Research Institute (NHGRI). The goal of ENCODE is to build a comprehensive parts list of functional elements in the human genome, including elements that act at the protein and RNA levels, and regulatory elements that control cells and circumstances in which a gene is active.

"The molecule PKR (the double-stranded RNA-activated protein kinase) was originally described as a sensor of viral infections, but its function in the brain was totally unknown," said Dr. Mauro Costa-Mattioli, assistant professor of neuroscience at BCM and senior author of the paper. Since the activity of PKR is altered in a variety of cognitive disorders, Costa-Mattioli and colleagues decided to take a closer look at its role in the mammalian brain. Super memory The authors discovered that mice lacking PKR in the brain have a kind of "super" memory. "

"Performing short cycle sprints three times a week could be enough to prevent and possibly treat type 2 diabetes, a study suggests. Scientists at the University of Bath asked volunteers to perform two 20-second cycle sprints on exercise bikes, three times per week. After six weeks, researchers in the university's department of health saw a 28% improvement in their insulin function."

"Our knowledge of species and functional composition of the human gut microbiome is rapidly increasing, but it is still based on very few cohorts and little is known about variation across the world. By combining 22 newly sequenced faecal metagenomes of individuals from four countries with previously published data sets, here we identify three robust clusters (referred to as enterotypes hereafter) that are not nation or continent specific. We also confirmed the enterotypes in two published, larger cohorts, indicating that intestinal microbiota variation is generally stratified, not continuous. This indicates further the existence of a limited number of well-balanced host-microbial symbiotic states that might respond differently to diet and drug intake."

GeneMANIA helps you predict the function of your favourite genes and gene sets.