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Berkeley Open Infrastructure for Network Computing (BOINC) is an open source middleware system for volunteer and grid computing. It was originally developed to support the SETI@home project before it became useful as a platform for other distributed applications in areas as diverse as mathematics, medicine, molecular biology, climatology, and astrophysics. The intent of BOINC is to make it possible for researchers to tap into the enormous processing power of personal computers around the world.

a list of distributed computing projects based on BOINC middleware project developed at University of California, Berkeley. In many of these projects, users volunteer CPU time from their home computer. When there is idle time available to work on the distributed computing project, client software can detect and utilize the "spare CPU cycles." In some projects, a computer's graphics processor (GPU) may be employed to work on the project.

GPUGRID.net is a distributed computing infrastructure devoted to biomedical research. Thanks to the contribution of volunteers, GPUGRID scientists can perform molecular simulations to understand the function of proteins in health and disease.