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Genetics open courseware at MIT, lecture notes, problem sets, exams, study materials

Introducing your students to Scratch will provide your students with hands-on opportunities to think creatively, solve problems and work collaboratively.  Scratch is a visual programming platform created at the Massachusetts Institute of Technology (MIT) by the Lifelong Kindergarten Group at the MIT Media Lab and is available to all users free of charge. This web-based tool is designed for students ages 8 to 16 but used by people of all ages.  With Scratch, you can program your own interactive stories, games, and animations - and share your creations with others in the online community.

Engineers at MIT and the University of California at San Diego (UCSD) have devised a new way to detect cancer that has spread to the liver, by enlisting help from probiotics - beneficial bacteria similar to those found in yogurt.

This animation depicts the CRISPR-Cas9 method for genome editing - a powerful new technology with many applications in biomedical research, including the potential to treat human genetic disease. Feng Zhang, a leader in the development of this technology, is a faculty member at MIT, an investigator at the McGovern Institute for Brain Research, and a core member of the Broad Institute. Further information can be found on Prof. Zhang's website at http://zlab.mit.edu .

BLOSSOMS video lessons are enriching students' learning experiences in high school classrooms from Brooklyn to Beirut to Bangalore. Our Video Library contains over 50 math and science lessons, all freely available to teachers as streaming video and Internet downloads and as DVDs and videotapes.

Early-response genes, which are important for synaptic plasticity, are "switched off" under basal conditions by topological constraints. Neuronal activity triggers DNA breaks in a subset of early-response genes, which overrides these topological constraints, and "switches on" gene expression.

Sneezes play an important part in the spread of infections, but we don't know a huge amount about how they work. Lydia Bourouiba's lab at MIT is trying to change that, using slow motion footage and other measurements to study the fluid dynamics of sneezing.

More than 400 scientists, bioethicists, and historians from 20 countries on 6 continents have gathered this week in Washington, DC, for the Human Gene Editing Summit. The attendees are a veritable who's who of genome editing: Jennifer Doudna of the University of California, Berkeley, Emmanuelle Charpentier of Max Planck Institute for Infection Biology, and Feng Zhang of the Broad Institute of MIT and Harvard-the three discoverers of the CRISPR-Cas9 system's utility in gene editing-plus dozens of other big names in genome science. Cal Tech's David Baltimore along with the heads of the four national societies hosting the meeting (US National Academy of Sciences, US National Academy of Medicine, Chinese Academy of Sciences, and the U.K.'s Royal Society) provided opening remarks on Tuesday (December 1). And as I sat stage right in the NAS auditorium, I noticed the unmistakable rear profile of Harvard Medical School's George Church three rows in front of me. Church was scheduled to speak at a session later that afternoon about the application of CRISPR and other new precision gene editing techniques to the human germline-a hot-button topic since April, when a Chinese group published it had successfully modified the genomes of human embryos, and the National Institutes of Health (NIH) said it would not fund such research. Then in September, the U.S./U.K.-based Hinxton Group, an international consortium of scientists, policy experts, and bioethicists, said it supported the use of genetic editing in human embryos for limited applications in research and medicine.  

Following on the achievements of Chinese researchers, scientists in the United States have used CRISPR to manipulate the genomes of viable human embryos, MIT Technology Review reported yesterday (July 26). The work, not yet published, reportedly corrected defective genes from sperm donors in dozens of embryos, which were allowed to grow for several days.

Muscogee County School podcasts:  math, science, language arts, science videos

Over the last decade, as DNA-sequencing technology has grown ever faster and cheaper, our understanding of the human genome has increased accordingly. Yet scientists have until recently remained largely ham-fisted when they've tried to directly modify genes in a living cell. Take sickle-cell anemia, for example. A debilitating and often deadly disease, it is caused by a mutation in just one of a patient's three billion DNA base pairs. Even though this genetic error is simple and well studied, researchers are helpless to correct it and halt its devastating effects.