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The PBL Clearinghouse contains problems from a wide variety of disciplines. As the problems and supporting materials are covered by the Creative Commons Attribution-NonCommercial 4.0 International License, you are welcome to borrow and adapt these problems for your classroom. Because these files are open sourced, your students may search and discover the teaching notes and solutions. We encourage you to make changes, adapt the problems to your specific goals and classroom contexts and thereby discourage your students from "borrowing" solutions or otherwise circumventing your instructional goals.

Problem-based learning (PBL) is an exciting way to learn biology and is readily incorporated into large classes in a lecture hall environment. PBL engages students in solving authentic biological case problems, stimulating discussion among students and reinforcing learning. A problem-based learning environment emulates the workplace and develops self-directed learners. This is preferable to a mimetic learning environment in which students only watch, memorize, and repeat what they have been told. The examples given here are suitable for use in a first year college biology lecture theater, but the method is applicable to any class size and educational level. [A more detailed explanation of PBL in Biology may be found in Chapter Four of INSPIRING STUDENTS, published in 1999 by Kogan Page.]

CASES Online is a collection of inquiry-based lessons to engage K-12 and undergraduate students in exploring the science behind real-world problems. Through CASES, you can transform your students into motivated investigators, self-directed and life-long learners, critical thinkers and keen problem solvers. Our cases are grounded in Problem-Based Learning (PBL), Investigative Case-Based Learning (ICBL), and related student-centered pedagogies.

 This session will showcase several PBL lessons and units that incorporate multiple Common Instructional Framework Strategies and authentic inquiry experiences in order to facilitate mastery of science concepts.  

Metacognition refers to awareness of one's own knowledge-what one does and doesn't know-and one's ability to understand, control, and manipulate one's cognitive processes (Meichenbaum, 1985). It includes knowing when and where to use particular strategies for learning and problem solving as well as how and why to use specific strategies. Metacognition is the ability to use prior knowledge to plan a strategy for approaching a learning task, take necessary steps to problem solve, reflect on and evaluate results, and modify one's approach as needed.

This directed case study examines differences between the exponential and logistic growth models in biology and how they are applied to solve real life problems. The narrative follows a student returning to the United States as he tries to assess his possible exposure to Middle East Respiratory Syndrome (MERS). To better understand his risk, James needs to get up to speed on a variety of topics including the difference between infection, transmission, virulence, etc., and how these topics can be mathematically modeled not only in relation to MERS, but also with respect to Ebola and influenza. This case was designed for use in the second semester of a biocalculus course or a course involving ordinary differential equations, which are appropriate for second year undergraduate students majoring in biology, pre-med, and bio-mathematics. These students typically have completed a semester of calculus and one year of general biology. The case provides an opportunity for students to develop their understanding of differential equations and increase their appreciation of mathematics as it applies to solving a problem of biology.

Genetics open courseware at MIT, lecture notes, problem sets, exams, study materials

Palm oil - which appears in a dizzying amount of food and cosmetic products, and is a feedstock for biofuel - poses many environmental problems. It's the largest driver of Indonesian deforestation, which destroys habitat and contributes to climate change. And ponds of wastewater at palm oil refineries release immense amounts of methane, a greenhouse gas 34 times more potent than carbon dioxide.

In this activity, students learn why evolution is at the heart of a world health threat. They will investigate the increasing problem of antibiotic resistance in such menacing diseases as tuberculosis and influenza. Students take on the role of staff at a public health agency who are trying to communicate the widespread problem of evolving disease-causing agents to the public.

Learn how to set up and solve a genetic problem involving multiple alleles using ABO blood types as an example! The Amoeba Sisters walk you through the different phenotypes/genotypes of ABO blood types and how to solve these problems using a Punnett square.

 is a web-based library of inquiry-based character-driven animated mysteries paired with differentiated supplemental activities that exposes students to the thrill of problem-solving. Mosa Mack allows educators to engage students while teaching standards-aligned content in a fun and engaging way while modeling scientific processing skills. Through its female protagonist whose passion for problem solving drives each story, Mosa Mack promotes diversity in the sciences while simultaneously providing teachers with an accessible way to incorporate inquiry into the classroom. Mosa Mack's unique inquiry-based approach targets the development of critical thinking skills for all students, with a particular focus on girls and minorities with historically low participation STEM fields.

CASES Online is a collection of investigative lessons, or "cases," for K-12 and undergraduate science education. Using principles of Problem-Based Learning and Investigative Case-Based Learning (and related student-centered pedagogies), our cases are designed to engage students in exploring the science behind real-world problems. Our cases address a variety of learning objectives across the sciences and mathematics. Although our K-12 cases were designed for use in Georgia and meet our state education standards, we have also included the relevant National Science Education Standards. CASES Online is designed to be used by K-12 and undergraduate science educators. By searching our collection, educators can find cases appropriate to their grade levels, subjects, and topics of interest. In order to download case materials for use in the classroom, educators must first register. While there is no charge to register, download, or use these cases -- we request that all users follow the guidelines outlined under our Terms of Use. Educators are also encouraged to submit cases of their own to our collection. To learn how best to use CASES Online, explore the User Guide; otherwise, begin to transform your classroom by searching for cases.

This index organizes teaching resources by topic-related issue and provides teaching resources (case studies, problems, videos, articles, activities, and other resources) which can be used to to facilitate the teaching of introductory non-majors biology using Problem or Case Studies Based Learning.

Most teens get between two and four colds a year. They may also get the flu if they're not vaccinated. The following activities will help your students learn the importance of protecting themselves from colds and flu so they can avoid missing class time.

Different disciplines follow different versions of the inquiry process. Graphic comparing: problem solving, scientific method, writing process, computation, theater, and engineering design.

Whether you call it textspeak, techspeak, or a reason for Shakespeare to spin madly in his grave, technology is impacting the way we think, connect, and communicate.

This interrupted case study tells the story of Michael, a Harvard law graduate with a stressful job and a seemingly heavy drinking problem. Students are provided with background information, medical history, and lab results in order to guide them towards determining what is wrong with Michael. This study highlights cirrhosis and the effects of alcohol abuse on the liver. Before beginning the case study, students should have a background in the physiological role of the liver and the breakdown of hemoglobin. Students are asked to use the information provided for them in the case study to gather more information about liver cells and their functions, alcohol, and alcoholic liver damage. Ultimately, using multiple blood tests, the Maddrey's discriminant function (DF) score, and results from a magnetic resonance elastography (MRE), they will diagnose Michael with alcoholic cirrhosis. This case was developed for use in a non-majors physiology course, but could easily be used for a majors class.

Paul Andersen shows you how to calculate the ch-squared value to test your null hypothesis. He explains the importance of the critical value and defines the degrees of freedom. He also leaves you with a problem related to the animal behavior lab. This analysis is required in the AP Biology classroom.

This case study focuses on the relationship between evolution and plasticity using a hands-on, inquiry-based approach. Students view examples from the literature that illustrate the difference between nature and nurture, or the relative contributions of genes and the environment in shaping phenotypes. Using the Trinidadian guppy system as an example, students learn about seminal work in the field in addition to exploring quantitative genetic techniques used to partition phenotypic variance between genes (G) and the environment (E). They use real data from one of the publications cited in the case to graph reaction norms illustrating GxE interactions at the family and population level. The inquiry-based approach means that students are introduced to new concepts in a stepwise fashion, and asked to develop and build their understanding using causal, explanatory evidence. The case concludes with an exercise in which students apply their knowledge to a real conservation problem in Trinidad and Tobago, where guppies are native. This case would be appropriate for an upper level biology, genetics, or evolution course.

This case study is based on the 2014 Ebola epidemic that spread to multiple highly populated countries in West Africa, making it the largest and most devastating outbreak in the history of the virus. The storyline, inspired by a compilation of factual information, unfolds through a fictional narrative wherein students play the role of an infectious disease specialist in training to learn about the techniques used in the detection, diagnosis, and management of Ebola virus outbreaks. The story is presented as an interrupted "clicker case" that combines problem-based case teaching methods with simulated biological laboratory inquiry through the use of Case It, a free molecular biology software, along with the NCBI's online bioinformatics tools and databases. Students work in groups to collaboratively explore various biological and social aspects of this infectious disease outbreak. This case was developed for senior students at the secondary level and can be modified for use in an introductory biology, microbiology, or epidemiology course at the undergraduate level.