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More than 400 scientists, bioethicists, and historians from 20 countries on 6 continents have gathered this week in Washington, DC, for the Human Gene Editing Summit. The attendees are a veritable who's who of genome editing: Jennifer Doudna of the University of California, Berkeley, Emmanuelle Charpentier of Max Planck Institute for Infection Biology, and Feng Zhang of the Broad Institute of MIT and Harvard-the three discoverers of the CRISPR-Cas9 system's utility in gene editing-plus dozens of other big names in genome science. Cal Tech's David Baltimore along with the heads of the four national societies hosting the meeting (US National Academy of Sciences, US National Academy of Medicine, Chinese Academy of Sciences, and the U.K.'s Royal Society) provided opening remarks on Tuesday (December 1). And as I sat stage right in the NAS auditorium, I noticed the unmistakable rear profile of Harvard Medical School's George Church three rows in front of me. Church was scheduled to speak at a session later that afternoon about the application of CRISPR and other new precision gene editing techniques to the human germline-a hot-button topic since April, when a Chinese group published it had successfully modified the genomes of human embryos, and the National Institutes of Health (NIH) said it would not fund such research. Then in September, the U.S./U.K.-based Hinxton Group, an international consortium of scientists, policy experts, and bioethicists, said it supported the use of genetic editing in human embryos for limited applications in research and medicine.  

Scientists have genetically engineered monkeys so that they exhibit behaviors similar to autism, with a goal of testing potential therapies on the animals in hopes that their resemblance to humans will yield more answers about the disorder. The scientists found that the monkeys showed "very similar behaviors related to human autism patients, including repetitive behaviors, increased anxiety and, most importantly, defects in social interactions," said Zilong Qiu, a leader of the research at the Institute of Neuroscience at the Chinese Academy of Sciences in Shanghai. The team is now imaging the brains of the monkeys, he said, "trying to identify the deficiency in the brain circuits that is responsible for the autism-like behavior."

 In one of the first successful attempts at genetically engineering mosquitoes, HHMI researchers have altered the way the insects respond to odors, including the smell of humans and the insect repellant DEET. The research not only demonstrates that mosquitoes can be genetically altered using the latest research techniques, but paves the way to understanding why the insect is so attracted to humans, and how to block that attraction. "The time has come now to do genetics in these important disease-vector insects.

Human-engineered microbes are workhorses of the pharmaceutical and chemical industries, churning out biofuels, drugs, and many other products. But they can cause big problems if they become contaminated by other microbes or viruses or escape into the environment. Now, a new type of microbe that can survive only on artificial nutrients promises better security against such mishaps. The strategy, described in two papers in this week's issue of Nature, might ultimately be used to control genetically engineered plants or other organisms released into the wild to create products or clean up pollution.

Climate change and the human contribution to this change is sometimes denied or depicted as an uncertainty. However, according to the American Association for the Advancement of Science (see References and Further Reading), climate change is not controversial: 97 percent of climate scientists are certain that human-caused climate change is occurring. Climate research is continuing, with scientists and engineers working to predict the consequences of climate change and finding ways to overcome its negative impact.

This case study examines the molecular methods that were used to reverse engineer the 1918 influenza virus strain in order to try and solve the mystery of why it was so deadly. The story starts in the 1950s with the unsuccessful attempts to culture the influenza virus and follows scientists through to the turn of the century when cutting edge molecular tools enabled scientists to finally resurrect the 1918 virus through reverse genetics. The history and methods involved in resurrecting this deadly virus are reviewed in class with a PowerPoint presentation containing clicker questions (answered with a personal response system) and discussion questions (answered in small groups). This "clicker case" is suitable for high school biology and lower division undergraduate biology classes for non-majors. It could also be used in any lower division non-major class focused on human disease and the history of human disease.

Researchers led by Terra D. Barnes of Washington University discovered that their genetically-engineered mice stutter due to DNA defects in a humdrum "housekeeping" gene. This gene codes for a protein that simply places a "routing tag" on certain enzymes that shred cellular trash. The tag ensures that the shredding enzymes end up in chambers called lysosomes, basically the cell's garbage disposal. It's a mundane cellular activity, yet mutations in the same process in humans have also been linked to stuttering-a bizarrely specific condition for such a general gene. And, so far, scientists have no idea why the two are linked.

Human activities currently add about nine gigatons of carbon to the atmosphere yearly. Photosynthetic organisms on land and in the ocean absorb about five of those gigatons through the natural uptake of CO2, leaving to humans the task of dealing with the rest. But no matter how much carbon there is, capturing it and preventing it from reentering the atmosphere is an immense engineering challenge; even today's best technology is orders of magnitude less effective than photosynthesis at trapping atmospheric carbon.

DNA is an interactive Web site where students can learn about DNA and its structure and function, the scientific history of its discovery and its development into a powerful tool in biology, technology, and medicine, and about the Human Genome Project, genetic engineering, and some of the implications and ethical issues surrounding genetic technology.

The wandering spider boasts one of the world's most sensitive vibration detectors: It can pick up the slightest rustling of a leaf from several meters away. Now, scientists have developed similar sensors that can detect simple human speech. The technology could lead to wearable electronics for speech recognition, health monitoring, and more.

Chinese scientists say they've genetically modified human embryos for the very first time. The team attempted to modify the gene responsible for beta-thalassaemia, a potentially fatal blood disorder, using a gene-editing technique known as CRISPR/Cas9. Gene editing is a recently developed type of genetic engineering in which DNA is inserted, replaced, or removed. Here, experts weigh-in with ethical questions and considerations.

For at least 10,000 years, humans have been cultivating plants and selectively breeding them for fast growth, pest resistance, long-term survival in storage, and bigger and better fruit. We've been domesticating animals for just as long, selecting for traits that suited our needs, such as size, appearance, or even personality. For a few decades, we've also had genetic engineering methods for getting the characteristics we want in plants, animals, and microorganisms.

Genetic and biotechnology can improve food security, the environment and public health. Yet dramatic innovation can lead to unintended consequences and present ethical challenges. In theory, the study of genetics and related cutting edge sciences are widely celebrated. But in practice, the words "gene" and "genetic engineering" often stir fear and misunderstanding when applied to biomedicine and farming. Intricate science scares people who don't understand risk and complexity. What is the potential of agricultural and human genetics? The commitment of the GLP is to promote public awareness of genetics and science literacy.

The Food and Drug Administration just approved the AquAdvantage Salmon, a fish genetically engineered to grow more quickly than its conventional counterparts. It's the first GMO animal for human consumption approved for sale in the United States.

Designer babies, the end of diseases, genetically modified humans that never age. Outrageous things that used to be science fiction are suddenly becoming reality. The only thing we know for sure is that things will change irreversibly.

Based on a comprehensive analysis of the scientific evidence, as required by the Federal Food, Drug and Cosmetic Act (FD&C Act), the FDA has determined that AquAdvantage Salmon meets the statutory requirements for safety and effectiveness under the FD&C Act. The salmon are safe to eat, the introduced DNA is safe for the fish itself, and the salmon meet the sponsor's claim about faster growth. Because the sponsor has met these requirements, the FDA must approve the application. The FDA has also analyzed the potential environmental impact that an approval of the AquAdvantage Salmon application would have on the quality of the human environment in the United States and has issued its final Environmental Assessment and Finding of No Significant Impact.

In this interactive activity adapted from the HHMI Outreach Program at Harvard University, learn about the ways in which stem cells can be used to treat and help cure diseases in humans. The activity explains what stem cells are and how they're produced, and provides details on their existing or potential therapeutic role in diseases related to the pancreas, liver, lungs, and bone marrow.

Scientists at AgResearch in New Zealand have successfully produced healthy transgenic cows that make modified milk or human therapeutic proteins in their milk.

"That changed when NASA created the Landsat program, a series of satellites that would perpetually orbit our planet, looking not out but down. Surveillance spacecraft had done that before, of course, but they paid attention only to military or tactical sites. Landsat was a notable exception, built not for spycraft but for public monitoring of how the human species was altering the surface of the planet."

The sounds of the rainforest include: the chirps of birds, the buzz of cicadas, the banter of gibbons. But in the background is the almost-always present sound of a chainsaw, from illegal loggers. Engineer Topher White shares a simple, scalable way to stop this brutal deforestation - that starts with your old cell phone.