Group items tagged

The DNA in just one of your cells gets damaged tens of thousands of times per day. Because DNA provides the blueprint for the proteins your cells need to function, this damage can cause serious issues-including cancer. Fortunately, your cells have ways of fixing most of these problems, most of the time. Monica Menesini details the processes of DNA damage and repair.

The conclusion is that the high-fat diet triggered chronic inflammation, which in turn triggered an autoimmune response in the mice's central nervous systems. Normally this response protects the brain from invaders like bacteria, but a high-saturated fat diet knocks the process off track, resulting in damage to synapses in the brain - specifically in the hippocampus. Since the hippocampus is a brain area central to memory and learning, the eventual outcome is impaired brain function. In short, the high-fat diet caused brain damage.

Scientists and clinicians have demonstrated that a neuroprotectant drug protects the human brain against the damaging effects of stroke. In patients who had ruptured brain aneurysm, which comprise a population of patients at very high risk of neurological damage, those treated with Tat-NR2B9c all had good neurological outcomes, whereas only 68% of those treated with placebo had good outcomes.

Lab mice that spent just two weeks in orbit showed early signs of liver damage upon returning to Earth, raising concern about what long-duration spaceflight might do to humans, researchers said Wednesday.

Multiple sclerosis is an autoimmune condition in which components of the immune system mistakenly attack the fatty lining around nerves in the brain and spinal cord. The majority of drugs currently used to tackle the symptoms of MS, therefore, focus on preventing this destruction by targeting the immune system. But a team of scientists think they may have found a different approach to treatment: targeting stem cells already present in the patient's nervous system.

Early-response genes, which are important for synaptic plasticity, are "switched off" under basal conditions by topological constraints. Neuronal activity triggers DNA breaks in a subset of early-response genes, which overrides these topological constraints, and "switches on" gene expression.

Humans construct boundaries -- around our homes, our neighborhoods, and our nations -- to bring order to a chaotic world. But we rarely consider how these boundaries affect other creatures. In this episode of Think Like A Scientist, we meet conservation photographer Krista Schlyer, who has spent the last seven years documenting the environmental effects of the U.S./Mexico border wall, and biologist Jon Beckmann, who studies how man-made barriers influence the movement of wildlife. Schlyer and Beckmann have seen damaging impacts of the border wall firsthand, but they remain optimistic. Humans probably won't stop constructing walls and fences any time soon, but planning our boundaries with wildlife in mind can help prevent these structures from causing environmental harm.

This interrupted case study tells the story of Michael, a Harvard law graduate with a stressful job and a seemingly heavy drinking problem. Students are provided with background information, medical history, and lab results in order to guide them towards determining what is wrong with Michael. This study highlights cirrhosis and the effects of alcohol abuse on the liver. Before beginning the case study, students should have a background in the physiological role of the liver and the breakdown of hemoglobin. Students are asked to use the information provided for them in the case study to gather more information about liver cells and their functions, alcohol, and alcoholic liver damage. Ultimately, using multiple blood tests, the Maddrey's discriminant function (DF) score, and results from a magnetic resonance elastography (MRE), they will diagnose Michael with alcoholic cirrhosis. This case was developed for use in a non-majors physiology course, but could easily be used for a majors class.

But scientists from the University of Southern California showed that, in mice, the Fasting Mimicking Diet (FMD) significantly lowered the percentage of damaging immune cells, while allowing the protective coating to regrow.

Our hard-wired stress response is designed to gives us the quick burst of heightened alertness and energy needed to perform our best. But stress isn't all good. When activated too long or too often, stress can damage virtually every part of our body. Sharon Horesh Bergquist gives us a look at what goes on inside our body when we are chronically stressed.

The study is the first to examine all of the gene networks affected by fructose that result in changes to brain function and metabolism-more than 20,000 genes in total. Although the study was conducted using rats, the researchers report that the majority of the sequenced genes are comparable to those in humans, including more than 200 genes in the hippocampus, a brain area crucial to memory, and 700 in the hypothalamus, the seat of the brain's metabolic control center.

For researchers, understanding how cancer cells function differently from normal cells lays the foundation for developing treatments designed to rid the body of cancer cells without damaging normal cells.

Damaged leg muscles grew stronger and showed signs of regeneration in three out of five men whose old injuries were surgically implanted with extracellular matrix derived from pig bladder, according to a new study. Early findings are from a human trial of the process as well as from animal studies.

A team of scientists, in a groundbreaking analysis of data from hundreds of sources, has concluded that humans are on the verge of causing unprecedented damage to the oceans and the animals living in them. "We may be sitting on a precipice of a major extinction event," said Douglas J. McCauley, an ecologist at the University of California, Santa Barbara, and an author of the new research, which was published on Thursday in the journal Science.

The question of cell renewal is one that all of us have intuitive daily experience with. We all notice that our hair falls out regularly, yet we don't get bald (at least not until males reach a certain age!).  Similarly, we have all had the experience of cutting ourselves only to see how new cells replaced their damaged predecessors. And we donate blood or give blood samples without gradually draining our circulatory system. All of these examples point to a replacement rate of cells, that is characteristic of different tissues and in different conditions, but which makes it abundantly clear that for many cell types renewal is a part of their story.

In this video Paul Andersen answers the very simple question: What is cancer? He explains how damage to the DNA can create uncontrolled cell growth. He explains how malignant tumors can spread the disease throughout the body and gives possible treatments.

As the prevalence of genetically modified organisms (GMOs) continues to rise, there has been an increasing public interest for information concerning the safety of these products. Concerns generally focus on how the GMO may affect the environment or how it may affect the consumer. One specific concern is the possibility for GMOs to negatively affect human health. This could result from differences in nutritional content, allergic response, or undesired side effects such as toxicity, organ damage, or gene transfer.

The heavy impact on the environment of meat production was known but the research shows a new scale and scope of damage, particularly for beef. The popular red meat requires 28 times more land to produce than pork or chicken, 11 times more water and results in five times more climate-warming emissions. When compared to staples like potatoes, wheat, and rice, the impact of beef per calorie is even more extreme, requiring 160 times more land and producing 11 times more greenhouse gases.

Would you rather be bitten by a venomous rattlesnake or touch a poisonous dart frog? While both of these animals are capable of doing some serious damage to the human body, they deliver their dangerous toxins in different ways. Rose Eveleth sheds light on the distinction between poison and venom (and why you shouldn't treat either one like you've seen in the movies).

High quality real time animations of processes