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Matti Narkia

Phospholipase A2-generated lipid mediators in the brain: the good, the bad, and the ugly. - Neuroscientist. 2006 Jun - 0 views

nro.sagepub.com/...245

2006 June study review Phospholipase_A PLA2 AA DHA EPA Lysophosphatidylcholine 4-hydroxynonenal platelet_activating_factor Alzheimer's_disease Alzheimer's Ischemia spinal_cord_injury head_injury brain lipid_mediators nutrition medline 4-HNE

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    Phospholipase A2-generated lipid mediators in the brain: the good, the bad, and the ugly. Farooqui AA, Horrocks LA. Neuroscientist. 2006 Jun;12(3):245-60. Review. PMID: 16684969 DOI: 10.1177/1073858405285923
Matti Narkia

Omega 3 fatty acids and the brain: review of studies in depression (full text PDF) - 0 views

www.biovita.fi/...Sinclair2007.pdf

2007 study review humans omega-3 brain depression DHA E-EPA EPA membrane function dopamine BDNF AA turnover omega-6 nutrition medline

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  • Matti Narkia on 18 Nov 09
     
    Omega 3 fatty acids and the brain: review of studies in depression. Sinclair AJ, Begg D, Mathai M, Weisinger RS. Asia Pac J Clin Nutr. 2007;16 Suppl 1:391-7. Review. PMID: 17392137 This paper discusses the clinical studies conducted in the area of depression and omega 3 PUFA and the possible mechanisms of action of these PUFA. It is clear from the literature that DHA is involved in a variety of processes in neural cells and that its role is far more complex than simply influencing cell membrane properties.
Matti Narkia

Comparison of biochemical effects of statins and fish oil in brain: the battle of the titans. - ScienceDirect - Brain Research Reviews : - 0 views

www.sciencedirect.com/science

2007 December study review HMG-CoA_reductase statins fish_oil EPA DHA omega-3 eicosanoids docosanoids oxidative_stress inflammation resolvins protectins neuroprotectins neurological disorders brain nutrition medline neurology

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    Comparison of biochemical effects of statins and fish oil in brain: the battle of the titans. Farooqui AA, Ong WY, Horrocks LA, Chen P, Farooqui T. Brain Res Rev. 2007 Dec;56(2):443-71. Epub 2007 Oct 23. Review. PMID: 17959252 doi:10.1016/j.brainresrev.2007.09.004    
Matti Narkia

Dietary long-chain n-3 fatty acids for the prevention of cancer: a review of potential mechanisms -- Larsson et al. 79 (6): 935 -- American Journal of Clinical Nutrition - 0 views

www.ajcn.org/...935

2004 June ajcn study review nutrition medline diet cancer omega-3 EPA DHA AA mechanism mechanisms alpha-linolenic_acid ALA carcinogenesis eicosanoids fish prevention fish_oil cancer_prevention

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    Dietary long-chain n-3 fatty acids for the prevention of cancer: a review of potential mechanisms. Larsson SC, Kumlin M, Ingelman-Sundberg M, Wolk A. Am J Clin Nutr. 2004 Jun;79(6):935-45. Review. PMID: 15159222
Matti Narkia

Controlling inflammation: a fat chance? -- Flower and Perretti 201 (5): 671 -- The Journal of Experimental Medicine - 0 views

www.jem.org/...671

2005 March study review health nutrition arachidonic_acid omega-6 AA omega-3 EPA inflammation anti-inflammatory COX-2 resolvin resolvins resolvin_ E1 RvE1 NF-kappaB NF-kB fish_oil medline

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    Controlling inflammation: a fat chance? Flower RJ, Perretti M. J Exp Med. 2005 Mar 7;201(5):671-4. Review. PMID: 15753201 doi:10.1084/jem.20050222
Matti Narkia

Targeting lipoxygenases with care. - ScienceDirect - Chemistry & Biology 2006 Nov - 0 views

www.sciencedirect.com/science

2006 November study research fish_oil omega-3 EPA resolvin E2 resolvins resolvin_E2 RvE2 5-LOX LOX lipoxins lipoxin omega-6 AA lipoxin_A4 LXA4 lipoxin_B4 LXB4 aspirin COX-2 12-LOX 15R-HETE 5S-HEPE nutrition medline COX RvE1

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    Targeting lipoxygenases with care. de Souza PM, Newson J, Gilroy DW. Chem Biol. 2006 Nov;13(11):1121-2. PMID: 17113992 doi:10.1016/j.chembiol.2006.11.002  
Matti Narkia

Eicosapentaenoic acid perturbs signalling via the NFkappaB transcriptional pathway in pancreatic tumour cells. - .[Int J Oncol. 2003] - PubMed Result - 0 views

www.ncbi.nlm.nih.gov/...14612948

2003 December study research in_vitro omega-3 EPA omega-6 AA IkappaBalpha NF-kappaB activation pancreatic cancer pancreatic_cancer nutrition medline NF-KB

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    Eicosapentaenoic acid perturbs signalling via the NFkappaB transcriptional pathway in pancreatic tumour cells. Ross JA, Maingay JP, Fearon KC, Sangster K, Powell JJ. Int J Oncol. 2003 Dec;23(6):1733-8. PMID: 14612948
Matti Narkia

A lipidomic analysis of nonalcoholic fatty liver disease. - Hepatology. 2007 Oct - Wiley InterScience :: Session Cookies - 0 views

www3.interscience.wiley.com/...HTMLSTART

2007 October Hepatology study research epidemiological humans non-alcoholic fatty liver disease non-alcoholic_fatty_liver_disease NAFLD NASH omega-3 AA EPA DHA lipds nutrition medline

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    A lipidomic analysis of nonalcoholic fatty liver disease. Puri P, Baillie RA, Wiest MM, Mirshahi F, Choudhury J, Cheung O, Sargeant C, Contos MJ, Sanyal AJ. Hepatology. 2007 Oct;46(4):1081-90. PMID: 17654743 DOI: 10.1002/hep.21763
Matti Narkia

Why fish oils may not always be adequate treatments for depression or other inflammatory illnesses: docosahexaenoic acid, an omega-3 polyunsaturated fatty acid, induces a Th-1-like immune response. - .[Neuro Endocrinol Lett. 2007] - PubMed Result - 0 views

www.ncbi.nlm.nih.gov/...18063921

2007 December study research clinical_trial ex_vivo humans omega-3 fish_oil EPA DHA omega-6 AA depression immune function immunity IFN-gamma IL-10 IFN-gamma_IL-10 IFN-gamma:IL-10 ratio nutrition medline Th1 TNF-alpha fish oil

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    Why fish oils may not always be adequate treatments for depression or other inflammatory illnesses: docosahexaenoic acid, an omega-3 polyunsaturated fatty acid, induces a Th-1-like immune response. Maes M, Mihaylova I, Kubera M, Bosmans E. Neuro Endocrinol Lett. 2007 Dec;28(6):875-80. PMID: 18063921
Matti Narkia

Differential killing of human carcinoma cells supplemented with n-3 and n-6 polyunsaturated fatty acids. - .[J Natl Cancer Inst. 1986] - PubMed Result - 0 views

www.ncbi.nlm.nih.gov/...3464797

1986 November JNCI study research in_vitro omega-3 omega-6 cancer normal cells carcinoma differential killing cytotoxic EPA GLA AA PUFA PUFAs nutrition medline

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    Differential killing of human carcinoma cells supplemented with n-3 and n-6 polyunsaturated fatty acids. Bégin ME, Ells G, Das UN, Horrobin DF. J Natl Cancer Inst. 1986 Nov;77(5):1053-62. PMID: 3464797
Matti Narkia

Immunomodulation by omega-3 fatty acids - Prostaglandins Leukot Essent Fatty Acids. 2007 Nov-Dec - 0 views

www.plefa.com/...abstract

2007 November study review immunomodulation omega-3 EPA DHA docosanoids resolvins resolvin immune cells cell membrane membranes anti-iflammatory lipid_mediators nutrition medline omega-6 AA eicosanoids

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    Immunomodulation by omega-3 fatty acids. Calder PC. Prostaglandins Leukot Essent Fatty Acids. 2007 Nov-Dec;77(5-6):327-35. Epub 2007 Nov 26. Review. PMID: 18032006 doi:10.1016/j.plefa.2007.10.015
Matti Narkia

Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators : Abstract : Nature Reviews Immunology - 0 views

www.nature.com/...nri2294.html

2008 May study review anti-inflammatory pro-resolution resolution resolving inflammation lipid mediators lipid_mediators resolvins resolvin protectins lipoxins lipoxin nutrition medline omega-3 EPA DHA omega-6 AA eicosanoids

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    Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators. Serhan CN, Chiang N, Van Dyke TE. Nat Rev Immunol. 2008 May;8(5):349-61. Review. PMID: 18437155 doi:10.1038/nri2294
Matti Narkia

The relationship between the fatty acid composition of immune cells and their function - Prostaglandins Leukot Essent Fatty Acids. 2008 Sep-Nov - 0 views

www.plefa.com/...abstract

2008 October study review omega-3 EPA DHA omega-6 AA fish_oil inflammation resolution eicosanoids cytokine macrophages lymphocytes resolvins resolvin nutrition medline immune cells immune_cells anti-inflammatory lipid_mediators

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    The relationship between the fatty acid composition of immune cells and their function. Calder PC. Prostaglandins Leukot Essent Fatty Acids. 2008 Sep-Nov;79(3-5):101-8. Epub 2008 Oct 23. Review. PMID: 18951005 doi:10.1016/j.plefa.2008.09.016
Matti Narkia

Novel omega -- 3-derived local mediators in anti-inflammation and resolution. - ScienceDirect - Pharmacology & Therapeutics : - 0 views

www.sciencedirect.com/science

2005 January study review anti-inflammatory lipid_mediators omega-3 EPA DHA fish_oil leukocytes eicosanoids aspirin inflammation resolution lipoxin lipoxins omega-6 AA resolvins resolvin docosatrienes neuroprotectins neuroprotectin nutrition medline

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    Novel omega -- 3-derived local mediators in anti-inflammation and resolution. Serhan CN. Pharmacol Ther. 2005 Jan;105(1):7-21. Review. PMID: 15626453 doi:10.1016/j.pharmthera.2004.09.002
Matti Narkia

Different effects of n-6 and n-3 polyunsaturated fatty acids on the activation of rat smooth muscle cells by interleukin-1 beta. - J Lipid Res. 2003 Mar - 0 views

www.jlr.org/...601

2003 March study research in_vitro AA EPA DHA PLA2 sPLA2 cPLA2 smooth_muscle_cells nutrition medline omega-3 omega-6 IL-1beta PGE2 COX-2

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    Different effects of n-6 and n-3 polyunsaturated fatty acids on the activation of rat smooth muscle cells by interleukin-1 beta. Bousserouel S, Brouillet A, Béréziat G, Raymondjean M, Andréani M. J Lipid Res. 2003 Mar;44(3):601-11. Epub 2003 Jan 1. PMID: 12562859 doi:10.1194/jlr.M200092-JLR200
Matti Narkia

Prostacyclin - Wikipedia, the free encyclopedia - 0 views

en.wikipedia.org/...Prostacyclin

prostacyclin PGI2 info reference wikipedia PGI3 omega-6 AA omega-3 EPA vasodilator COX COX-1 COX-2 endothelial_cells nutrition eicosanoid eicosanoids

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    Prostacyclin (or PGI2) is a member of the family of lipid molecules known as eicosanoids.\nAs a drug, it is also known as "epoprostenol".[1] The terms are sometimes used interchangeably Prostacyclin (PGI2) chiefly prevents formation of the platelet plug involved in primary hemostasis (a part of blood clot formation). It is also an effective vasodilator. Prostacyclin's interactions in contrast to thromboxane (TXA2), another eicosanoid, strongly suggest a mechanism of cardiovascular homeostasis between the two hormones in relation to vascular damage.
Matti Narkia

Dietary supplementation with eicosapentaenoic acid, but not with other long-chain n-3 or n-6 polyunsaturated fatty acids, decreases natural killer cell activity in healthy subjects aged >55 y.- Am J Clin Nutr. 2001 Mar;73(3):539-48. - 0 views

www.ajcn.org/...539

2001 March ajcn clinical_trial rct humans elderly older old fish_oil immunity immmune response natural_killer_cells NK_cells activity omega-3 ALA DHA EPA omega-6 AA GLA PUFA PUFAs nutrition medline fish oil

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    Dietary supplementation with eicosapentaenoic acid, but not with other long-chain n-3 or n-6 polyunsaturated fatty acids, decreases natural killer cell activity in healthy subjects aged >55 y. Thies F, Nebe-von-Caron G, Powell JR, Yaqoob P, Newsholme EA, Calder PC. Am J Clin Nutr. 2001 Mar;73(3):539-48. PMID: 11237929
Matti Narkia

The role of eicosanoids in the brain. [Asia Pac J Clin Nutr. 2008] - PubMed Result - 0 views

www.ncbi.nlm.nih.gov/...18296342

2008 study review role eicosanoids brain AA omega-6 omega-3 EPA DHA PLA2 nutrition medline 5-LOX COX

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    The role of eicosanoids in the brain. Tassoni D, Kaur G, Weisinger RS, Sinclair AJ. Asia Pac J Clin Nutr. 2008;17 Suppl 1:220-8. Review. PMID: 18296342 Liberation of these PUFA from the phosphoglycerides occurs via the action of specific phospholipases (PLA2).
Matti Narkia

Fish Oil - The Best Source and Optimal Dosing of this Anti-inflammatory Nutrient By Douglas MacKay, ND - 0 views

www.vrp.com/articles.aspx

vrp fish_oil info anti-inflammatory omega-3 omega-6 EPA DHA AA phospholipase_A2 PLA2 delta-6_desaturase D6D delta-5_desaturase D5D rancid rancidity

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    Because of their health-promoting abilities, omega-3 fatty acids have received recognition from some of the top medical organizations in the world including, the American Heart Association, American Diabetes Association, World Health Organization, United Kingdom Scientific Advisory Committee on Nutrition, European Society for Cardiology, and The British Nutrition Foundation.
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