Resolvin E2: identification and anti-inflammatory actions: pivotal role
of human 5-lipoxygenase in Resolvin E series biosynthesis.
Tjonahen E, Oh SF, Siegelman J, Elangovan S, Percarpio KB, Hong S,
Arita M, Serhan CN.
Chem Biol. 2006 Nov;13(11):1193-202.
PMID: 17114001
doi:10.1016/j.chembiol.2006.09.011
March 7, 2005
Boston, MA - The anti-inflammatory effect of fish oils appears to be due to a powerful anti-inflammatory compound called resolvin (resolution-phase interaction product) E1, which is produced from eicosapentaenoic acid (EPA), Dr Makoto Arita (Brigham and Women's Hospital and Harvard Medical School, Boston, MA) and colleagues report in the March 7, 2005 issue of the Journal of Experimental Medicine [1]. Arita writes, "At nanomolar levels, resolvin E1 dramatically reduced dermal inflammation, peritonitis, dendritic cell migration, and interleukin (IL)-12 production.
The contributions of aspirin and microbial oxygenase to the biosynthesis of anti-inflammatory resolvins: novel oxygenase products from omega-3 polyunsaturated fatty acids.
Arita M, Clish CB, Serhan CN.
Biochem Biophys Res Commun. 2005 Dec 9;338(1):149-57. Epub 2005 Aug 10. Review.
PMID: 16112645
doi:10.1016/j.bbrc.2005.07.181
Novel chemical mediators in the resolution of inflammation: resolvins and protectins.
Serhan CN.
Anesthesiol Clin. 2006 Jun;24(2):341-64. Review.
PMID: 16927933
Rapid appearance of resolvin precursors in inflammatory exudates: novel mechanisms in resolution.
Kasuga K, Yang R, Porter TF, Agrawal N, Petasis NA, Irimia D, Toner M, Serhan CN.
J Immunol. 2008 Dec 15;181(12):8677-87.
PMID: 19050288
Resolvin D1, protectin D1, and related docosahexaenoic acid-derived
products: Analysis via electrospray/low energy tandem mass spectrometry
based on spectra and fragmentation mechanisms.
Hong S, Lu Y, Yang R, Gotlinger KH, Petasis NA, Serhan CN.
J Am Soc Mass Spectrom. 2007 Jan;18(1):128-44. Epub 2006 Oct 19.
PMID: 17055291
doi:10.1016/j.jasms.2006.09.002
Resolvin E1 selectively interacts with leukotriene B4 receptor BLT1 and
ChemR23 to regulate inflammation.
Arita M, Ohira T, Sun YP, Elangovan S, Chiang N, Serhan CN.
J Immunol. 2007 Mar 15;178(6):3912-7.
PMID: 17339491
Identification of endogenous resolvin E1 and other lipid mediators
derived from eicosapentaenoic acid via electrospray low-energy tandem
mass spectrometry: spectra and fragmentation mechanisms.
Lu Y, Hong S, Yang R, Uddin J, Gotlinger KH, Petasis NA, Serhan CN.
Rapid Commun Mass Spectrom. 2007;21(1):7-22.
PMID: 17131464
Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1.
Arita M, Bianchini F, Aliberti J, Sher A, Chiang N, Hong S, Yang R, Petasis NA, Serhan CN.
J Exp Med. 2005 Mar 7;201(5):713-22.
PMID: 15753205
oi:10.1084/jem.20042031
Obesity-induced insulin resistance and hepatic steatosis are alleviated by {omega}-3 fatty acids: a role for resolvins and protectins.
González-Périz A, Horrillo R, Ferré N, Gronert K, Dong B, Morán-Salvador E, Titos E, Martínez-Clemente M, López-Parra M, Arroyo V, Clària J.
FASEB J. 2009 Feb 23. [Epub ahead of print]
PMID: 19211925
doi: 10.1096/fj.08-125674
Resolvins, docosatrienes, and neuroprotectins, novel omega-3-derived mediators, and their aspirin-triggered endogenous epimers: an overview of their protective roles in catabasis.
Serhan CN, Gotlinger K, Hong S, Arita M.
Prostaglandins Other Lipid Mediat. 2004 Apr;73(3-4):155-72. Review.
PMID: 15290791
ScienceDaily (Feb. 12, 2009) - According to a recent study, diets rich in omega-3 fatty acids protect the liver from damage caused by obesity and the insulin resistance it provokes. This research should give doctors and nutritionists valuable information when recommending and formulating weight-loss diets and help explain why some obese patients are more likely to suffer some complications associated with obesity. Omega-3 fatty acids can be found in canola oil and fish.