A signalling pathway that influences how sensitive cancer cells are to the beneficial effects of dietary restriction is described in this week's Nature.
Dietary restriction - eating less calories while maintaining essential vitamins and minerals - can extend lifespan, and reduce cancer incidence and growth. But some types of cancer cell are more sensitive to the anti-growth effects of dietary restriction than others, Nada Kalaany and David Sabatini report. The effect hinges on the activity of the phosphatidylinositol-3-kinase (PI3K) pathway. If the pathway is active, dietary restriction has no effect on cancer cells. However, if the pathway is inactive, tumours are sensitive to dietary restriction.
ScienceDaily (Feb. 25, 2009) - Researchers at Purdue University have precisely measured the impact of a high-fat diet on the spread of cancer, finding that excessive dietary fat caused a 300 percent increase in metastasizing tumor cells in laboratory animals.
Major types of dietary fat and risk of coronary heart disease: a pooled analysis of 11 cohort studies.
Jakobsen MU, O'Reilly EJ, Heitmann BL, Pereira MA, Bälter K, Fraser GE, Goldbourt U, Hallmans G, Knekt P, Liu S, Pietinen P, Spiegelman D, Stevens J, Virtamo J, Willett WC, Ascherio A.
Am J Clin Nutr. 2009 Feb 11. [Epub ahead of print]
PMID: 19211817
doi:10.3945/ajcn.2008.27124
Increased dietary protein consumed at breakfast leads to an initial and sustained feeling of fullness during energy restriction compared to other meal times.
Heather J. Leidy, Mandi J. Bossingham, Richard D. Mattes and Wayne W. Campbell
British Journal of Nutrition (2009), 101:798-803 Cambridge University Press
doi:10.1017/S0007114508051532
Estimation of the dietary requirement for vitamin D in healthy adults.\nCashman KD, Hill TR, Lucey AJ, Taylor N, Seamans KM, Muldowney S, Fitzgerald AP, Flynn A, Barnes MS, Horigan G, Bonham MP, Duffy EM, Strain JJ, Wallace JM, Kiely M.\nAm J Clin Nutr. 2008 Dec;88(6):1535-42.\nPMID: 19064513 [
Loren DJ, Seeram NP, Schulman RN, Holtzman DM. \nMaternal dietary supplementation with pomegranate juice is neuroprotective in an animal model of neonatal hypoxic-ischemic brain injury.\nPediatr Res. 2005 Jun;57(6):858-64. Epub 2005 Mar 17.\nPMID: 1577483
Dietary magnesium intake is related to metabolic syndrome in older Americans.
McKeown NM, Jacques PF, Zhang XL, Juan W, Sahyoun NR.
Eur J Nutr. 2008 Jun;47(4):210-6. Epub 2008 Jun 16.
PMID: 18560789
DOI: 10.1007/s00394-008-0715-x
(SACRAMENTO, Calif.) - Osteoporosis affects many women and can cause painful, disabling and even life-threatening fractures. Researchers from the UC Davis Department of Internal Medicine are seeking a simple, inexpensive way to prevent the disease.
Strontium citrate is a widely available, over-the-counter dietary supplement promoted to "improve bone health." Strontium is a natural element found in bone in all people. Strontium citrate is another form of strontium ranelate, a proven medication prescribed across Europe and Australia to treat and prevent osteoporosis and related fractures. Unlike pharmaceuticals, strontium citrate is not a prescribed medication and is inexpensive.
High dietary menaquinone intake is associated with reduced coronary calcification.\nBeulens JW, Bots ML, Atsma F, Bartelink ML, Prokop M, Geleijnse JM, Witteman JC, Grobbee DE, van der Schouw YT.\nAtherosclerosis. 2008 Jul 19. [Epub ahead of print]\nPMID: 18722618 \ndoi:10.1016/j.atherosclerosis.2008.07.010 \n
Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam Study.\nGeleijnse JM, Vermeer C, Grobbee DE, Schurgers LJ, Knapen MH, van der Meer IM, Hofman A, Witteman JC.\nJ Nutr. 2004 Nov;134(11):3100-5.\nPMID: 15514282
Dietary intake of vitamin K and risk of prostate cancer in the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Heidelberg).\nNimptsch K, Rohrmann S, Linseisen J.\nAm J Clin Nutr. 2008 Apr;87(4):985-92.\nPMID: 18400723
ScienceDaily (Feb. 26, 2009) - A study from the Harokopio University of Athens (Greece) suggests that adherence to a dietary pattern close to the Mediterranean diet, with high consumption of fish and olive oil and low red meat intake, has a significant impact in women skeletal health.
Dietary linolenic acid is inversely associated with calcified atherosclerotic plaque in the coronary arteries: the National Heart, Lung, and Blood Institute Family Heart Study.
Djoussé L, Arnett DK, Carr JJ, Eckfeldt JH, Hopkins PN, Province MA, Ellison RC; Investigators of the NHLBI FHS.
Circulation. 2005 Jun 7;111(22):2921-6. Epub 2005 May 31.
PMID: 15927976
doi: 10.1161/CIRCULATIONAHA.104.489534
A systematic review of the evidence supporting a causal link between dietary factors and coronary heart disease.
Mente A, de Koning L, Shannon HS, Anand SS.
Arch Intern Med. 2009 Apr 13;169(7):659-69.
PMID: 19364995
Conclusion: The associations suggest that replacing SFAs with PUFAs rather than MUFAs or carbohydrates prevents CHD over a wide range of intakes.
Major types of dietary fat and risk of coronary heart disease: a pooled analysis of 11 cohort studies.
Jakobsen MU, O'Reilly EJ, Heitmann BL, Pereira MA, Bälter K, Fraser GE, Goldbourt U, Hallmans G, Knekt P, Liu S, Pietinen P, Spiegelman D, Stevens J, Virtamo J, Willett WC, Ascherio A.
Am J Clin Nutr. 2009 May;89(5):1425-32. Epub 2009 Feb 11.
PMID: 19211817
doi:10.3945/ajcn.2008.27124