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Kenuvis Romero

Psilocybin (magic mushrooms) - 0 views

flipper.diff.org/...4384

shared by Kenuvis Romero on 23 Jun 13 - No Cached
  • The biosinthetic path that allow Psilocybin to be produced by mushrooms is as follow:
  • The several analogyes with triptophan aminoacid, with whom psilocybin has common origines are probably at the base of psilocybin ability to induced psychedelich alteration on humans.
  • Amino acids, including tryptophan, act as building blocks in protein biosynthesis. In addition, tryptophan functions as a biochemical precursor for many compounds like serotonin Serotonin (a neurotransmitter), synthesized via tryptophan hydroxylase. Serotonin, in turn, can be converted to melatonin (a neurohormone), via N-acetyltransferase and 5-hydroxyindole-O-methyltransferase activities
  • ...15 more annotations...
  • it's been noticed that psilocyn can indirectly raise dopamine concentration withing the basal ganglia.
  • Almost 50% of oral psilocybin is absorbed by stomach and gut; from here is lead to liver, where it's converted in psilocin, pharmacologically active form, that can furtherly be glucoronated and escreted with urine or converted in other psilocinics metabolites.
  • In rats, the median lethal dose (LD50) when administered orally is 280 milligrams per kilogram (mg/kg), approximately one and a half times that of caffeine. When administered intravenously in rabbits, psilocybin's LD50 is approximately 12.5 mg/kg
  • traces of the compund can be detected in unine even after 7 days.
  • Clinical studies show that psilocin concentrations in the plasma of adults average about 8 µg/liter within 2 hours after ingestion of a single 15 mg oral psilocybin dose; psychological effects occur with a blood plasma concentration of 4–6 µg/liter. Psilocybin is about 100 times less potent than LSD on a weight per weight basis, and the physiological effects last about half as long.
  • Monoamine oxidase inhibitors (MAOI) have been known to prolong and enhance the effects of psilocybin. Alcohol consumption may enhance the effects of psilocybin, because acetaldehyde, one of the primary breakdown metabolites of consumed alcohol, reacts with biogenic amines present in the body to produce MAOIs related to tetrahydroisoquinoline and β-carboline. Tobacco smokers can also experience more powerful effects with psilocybin, because tobacco smoke exposure decreases levels of MAO in the brain and peripheral organs.
  • Within 24 hours from administration 65% of the alucinogen is escreted by urine, while another 15-20% is excreted by bile and feces.
  • Psilocybin comprises approximately 1% of the weight of Psilocybe cubensis mushrooms, and so nearly 1.7 kilograms (3.7 lb) of dried mushrooms, or 17 kilograms (37 lb) of fresh mushrooms, would be required for a 60-kilogram (130 lb) person to reach the 280 mg/kg LD50 value.
  • This could lead to a lower usage o f glucose, but the same study admitted an increase glucose usage by the whole brain cell, meaning a differente use of this sugar while the drug is having effects.
  • use of MRI (functional magnetic resounance) showed that the decresed blood flow associate with decreasing in neural activity. A simple explanation for this unexpected situation could be the serotoning agonist action of psilocybin, action that seems to be focused more on 5-HT receptors than on 5-HT2A.
  • psilocibyn is able to act as a 5-HT agonist binding directly its receptors.
  • augmented glucose consumption in several brain regions; this lead to the conclusion that psilocybin is some way able to modify the physiological glucosal metabolic rate of our body
    • Kenuvis Romero
      Kenuvis Romero on 23 Jun 13
       
      Lower brain glucose metabolism is linked with increased capacity for working memory.
  • The strong inibition of the PCC is now thought to be most significant action of psilocybin on neural disaccoppiation
  • psilocybin can cause anxiety and increased heart rate and BP which is very counter- productive for someone on metoprolol and micardis.
  • propose the possibility to use psilocybin as a palliative therapy for terminal illness like cancer but also as a real antidepressive active principle available for the family of the patient. The rational is foundable in the fact that we usually administer SSRI as antidepressive agents, so psilocibyn sholud be useful in this purpose for its selective agonist action on 5-HT2A receptors
Mr. Eason

Educational Leadership:Reading: The Core Skill:The Challenge of Challenging Text - 131 views

www.ascd.org/...lenge-of-Challenging-Text.aspx

teaching text complexity literacy

shared by Mr. Eason on 24 Mar 12 - No Cached
  • The new standards instead propose that teachers move students purposefully through increasingly complex text to build skill and stamina.
  • higher-order thinking in reading depends heavily on knowledge of word meanings.
  • Students' ability to comprehend a piece of text depends on the number of unfamiliar domain-specific words and new general academic terms they encounter.
  • ...16 more annotations...
  • If students are to interpret the meanings such complex sentence structures convey, they need to learn how to make sense of the conventions of text—phrasing, word order, punctuation, and language.
  • Students who are aware of the patterns authors use to communicate complex information have an advantage in making sense of text.
  • A final determinant of text difficulty, however, depends on the reader's prior knowledge.
  • Students' background knowledge, including developmental, experiential, and cognitive factors, influences their ability to understand the explicit and inferential qualities of a text.
  • building skills, establishing purpose, and fostering motivation.
  • even students who have basic decoding skills sometimes struggle to deploy these skills easily and accurately enough to get a purchase on challenging text. To help these students develop reading fluency, teachers should give them lots of practice with reading the same text, as well as instruction to help them develop a stronger sense of where to pause in sentences, how to group words, and how their voices should rise or fall at various junctures when reading aloud.
  • maintaining understanding across a text.
  • pair repeated readings of the same text with questions that require the student to read closely for detail and key ideas.
  • Ongoing, solid vocabulary instruction
  • also on general academic words.
  • also explore the connections among words,
  • In contrast, in reading history and literature, readers need to be concerned with not just the causes of events, but also the human intentions behind these causes.
  • teachers should not convey so much information that it spoils the reading or enables students to participate in class without completing the reading; rather, they should let students know what learning to expect from the reading.
  • Teachers may be tempted to try to make it easier for students by avoiding difficult texts. The problem is, easier work is less likely to make readers stronger.
  • You need to create successive successes.
  • Students experience success in the company of their teacher, who combines complex texts with effective instruction.
  • Christine Dailey on 24 Mar 12
     
    What makes text difficult and how to teach skills for successful comprehension.
Donna Roper

Twittering, Not Frittering: Professional Development in 140 Characters | Edutopia - 15 views

www.edutopia.org/pment-technology-microblogging

shared by Donna Roper on 27 Jul 10 - Cached
  • Although some people argue that Twitter is one more distraction in a tech-saturated world, David Cosand says it's been a time-saver for him. He was writing a grant proposal recently to buy more technology for his school and realized he needed to learn more about document cameras. "I put a tweet out asking people which cameras they have found useful. In half an hour, I got great feedback from all over the country," he says, and he wound up narrowing down the list to an AVerVision CP300 model.
Jac Londe

Scientists capture first direct images of theoretically predicted magnetic monopoles - 19 views

www.physorg.com/...es-theoretically-magnetic.html

images capture scientists science onde

shared by Jac Londe on 25 Oct 10 - No Cached
  • first direct images of
  • magnetic monopoles
  • Image representing 12 micrometer x 12 micrometer of artificial magnetic metamaterial where monopoles can be seen at each end of the Dirac strings, visible as dark lines. The dark regions correspond to magnetic islands where the magnetization is reversed. (Image courtesy of Paul Scherrer Institute)
  • ...3 more annotations...
  • “A magnetic monopole is a ‘hypothetical’ particle that is a magnet with only one single magnetic pole,” says UCD Theoretical Physicist, Professor Hans-Benjamin Braun from the UCD School of Physics, who co-led the study with Dr Laura Heyderman from the Paul Scherrer Institute in Switzerland.
  • “Some of the most important theories explaining how quantum matter behaves in the universe are based on their existence, but they have eluded direct imaging since they were first theoretically conceived in the 1930s.”
  • Initially conceived by the British-Swiss theoretical physicist Dirac in 1931, monopoles were proposed to occur as emergent quasiparticles in so called pyrochlore spin-ice systems by Castelnovo, Moessner and Sondhi in 2008.
Ed Webb

The Wired Campus - Do Students Cheat More in Online Classes? Maybe not. - The Chronicle... - 0 views

chronicle.com/...8073

distance education plagiarism survey chronicle edu_trends

shared by Ed Webb on 16 Sep 09 - Cached
  • You can’t make any sweeping generalizations based on the results
  • older students tend to cheat less frequently than younger students
  • If you are interested in this topic, look for the interesting edited book called Student Plagiarism in an Online World: http://www.igi-global.com/reference/details.asp?ID=7031&v=tableOfContentsI wrote a chapter called, "Expect Originality! Using Taxonomies to Structure Assignments that Support Original Work." In it I discuss the complexities of plagiarism in the context of a digital culture of sharing and suggest that it is rarely black and white. I propose a continuum with intentional academic dishonesty on one end and original work on the other, with gradations in between. Based on my own research and teaching experience, I believe the instructional design and style of teaching can either make it easy-- or very difficult-- to cheat.
Pam Whitaker

Help Our Students With New Technology Tools - 0 views

www.donorschoose.org/...proposal.html

shared by Pam Whitaker on 28 May 09 - Cached
  • Pam Whitaker on 28 May 09
     
    Please check out this opportunity to help the students at my school have new technology tools. This will help them in many ways. We integrate all other courses with our technology projects. In a way these tools will help with every area of their learning at school.
Mallory Bau

Food Safety's Dirty Little Secret - US News and World Report - 16 views

www.usnews.com/...fetys-dirty-little-secret.html

shared by Mallory Bau on 09 Mar 10 - No Cached
  • Yet the FDA in particular has long been starved of funding and understaffed.
  • Congress is under pressure to take up major food-safety legislation this fall that would offer sweeping proposals for regulatory change.
Jac Londe

A propos de Cairn.info - 4 views

www.cairn.info/a-propos.php

cairn info sciences humaines publication edition france fraçaise livre livres magazine ouvrage encyclopédie

shared by Jac Londe on 12 Feb 11 - No Cached
  • Cairn.info
  • est né de la volonté de quatre maisons d'édition (Belin, De Boeck, La Découverte et Erès) ayant en charge la publication et la diffusion de revues de sciences humaines et sociales, d’unir leurs efforts pour améliorer leur présence sur l’Internet, et de proposer à d’autres acteurs souhaitant développer une version électronique de leurs publications, les outils techniques et commerciaux développés à cet effet.
Kevin Jarrett

Proposed Cuts Strike Teachers as Attacks on Their Value to Society - NYTimes.com - 30 views

www.nytimes.com/...03teacher.html

edreform

shared by Kevin Jarrett on 03 Mar 11 - No Cached
  • Kevin Jarrett on 03 Mar 11
     
    "Teachers Wonder, Why the Scorn?"
Jackie Rippy

Soviet Psychology: Psychology and Marxism Internet Archive - 14 views

www.marxists.org/...ch04.htm

Luria Activity Theory

shared by Jackie Rippy on 11 Aug 11 - Cached
    • Jackie Rippy
      Jackie Rippy on 11 Aug 11
       
      This points to stark differences - what about subtle differences between cultures. Do our symbols affect brain development - do our tools affect brain development?
  • Other Gestalt psychologists emphasized the common properties of mind in all cultures
  • shifts
  • ...12 more annotations...
  • in the basic forms, as well as in the content of people's thinking.
  • The early 1930
  • had experienced the conditions necessary to alter radically the content and form of their thought.
  • we expected that they would display a predominance of those forms of thought that come from activity that is guided by the physical features of familiar objects.
  • Therefore we began, as most field work with people does, by emphasizing contact with the people who would serve as our subjects. We tried to establish friendly relations so that experimental sessions seemed natural and non-threatening. We were particularly careful not to conduct hasty or unprepared presentations of the test materials.
  • As a rule, our experimental sessions began with long conversations which were sometimes repeated with the subjects in the relaxed atmosphere of a tea house, where the villagers spent most of their free time, or in camps in the field and in mountain pastures around the evening campfire. These talks were frequently held in groups. Even when the interviews were held with one person, the experimenter and other subjects made up a group of two or three who listened attentively to the person being interviewed and who sometimes offered remarks or comments on what he said. The talk often took the form of a free-flowing exchange of opinion between participants, and a particular problem might be solved simultaneously by two or three subjects, each proposing an answer. Only gradually did the experimenters introduce the prepared tasks, which resembled the “riddles” familiar to the population and therefore seemed like a natural extension of the conversation.
  • He characterized primitive thinking as “prelogical” and “loosely organized.” Primitive people were said to be indifferent to logical contradiction and dominated by the idea that mystical forces control natural phenomena
  • We conceived the idea of carrying out the first far-reaching study of intellectual functions among adults from a non-technological non-literate, traditional society
  • hamlets
  • nomad
  • 1. Women living in remote villages who were illiterate and who were not involved in any modern social activities. There were still a considerable number of such women at the time our study was made. Their interviews were conducted by women, since they alone had the right to enter the women's quarters. 2. Peasants living in remote villages who were in no way involved with socialized labor and who continued to maintain an individualistic economy. These peasants were not literate. 3. Women who attended short-term courses in the teaching of kindergarteners. As a rule, they had no formal schooling and almost no training in literacy. 4. Active kolhoz (collective farm) workers and young people who had taken short courses. They were involved as chairmen running collective farms, as holders of other offices on the, collective farm, or as brigade leaders. They had considerable experience in planning production, distributing labor, and taking stock of output. By dealing with other collective farm members, they had acquired a much broader outlook than isolated peasants. But they had attended school only briefly, and many were still barely literate. 5. Women students admitted to teachers school after two or three years of study. Their educational qualifications, however, were still fairly low.
  • Short-term psychological experiments would have been highly problematic under the field conditions we expected to encounter
Glenda Baker

K12 Online Conference | 2011 K-12 Online Conference Call for Proposals and Announcements - 57 views

k12onlineconference.org/?p=809

conference k12online11 education teachers

shared by Glenda Baker on 03 Oct 11 - No Cached
  • Glenda Baker on 03 Oct 11
     
    learning opportunity
A Gardner

The Teaching Profession Must Police Itself | Reflections of a Math Teacher Candidate - 44 views

mathequality.wordpress.com/...-profession-must-police-itself

teaching profession blog

shared by A Gardner on 01 May 11 - No Cached
  • how can teachers be assessed fairly to make sure they perform their duties competently?
  • teachers must propose some method to police our own
  • A deeper question to me is, how are lawyers, doctors, and other professionals judged?
  • A Gardner on 01 May 11
     
    If a student improves, learns, and progresses beyond where he/she was when they entered my class, yet remains below "proficient," I am to receive a failing grade. I think success needs redefined.
Thad Haines

Social Media: Why This Matters To Everyone In Education - 57 views

hetl.org/...tters-to-everyone-in-education

education social media social-media

shared by Thad Haines on 22 Oct 12 - No Cached
  • SJCNY Trainers on 22 Oct 12
     
    ""Social Media: Why It Matters to Everyone in Education" - an opinion article by Daniel Clark. The article explores social media and the use of social media in an educational context applying a staged model proposed by the author. Daniel Clark views social media as an immediate challenge with the potential to introduce major changes to educational approaches and paradigms. "
Kent Gerber

What the Web Said Yesterday - The New Yorker - 42 views

www.newyorker.com/...cobweb

web digital preservation archives digital archives preservation history scholarly communication citations

shared by Kent Gerber on 02 Feb 15 - No Cached
  • average life of a Web page is about a hundred days
    • Kent Gerber
      Kent Gerber on 02 Feb 15
       
      Where does this statistic come from?
  • Twitter is a rare case: it has arranged to archive all of its tweets at the Library of Congress.
  • Sometimes when you try to visit a Web page what you see is an error message: “Page Not Found.” This is known as “link rot,”
  • ...14 more annotations...
  • Or maybe the page has been moved and something else is where it used to be. This is known as “content drift,”
  • For the law and for the courts, link rot and content drift, which are collectively known as “reference rot,” have been disastrous.
  • According to a 2014 study conducted at Harvard Law School, “more than 70% of the URLs within the Harvard Law Review and other journals, and 50% of the URLs within United States Supreme Court opinions, do not link to the originally cited information.”
  • one in five links provided in the notes suffers from reference rot
  • 1961, in Cambridge, J. C. R. Licklider, a scientist at the technology firm Bolt, Beranek and Newman, began a two-year study on the future of the library, funded by the Ford Foundation and aided by a team of researchers that included Marvin Minsky, at M.I.T.
  • Licklider envisioned a library in which computers would replace books and form a “network in which every element of the fund of knowledge is connected to every other element.”
  • Licklider’s two-hundred-page Ford Foundation report, “Libraries of the Future,” was published in 1965.
  • Kahle enrolled at M.I.T. in 1978. He studied computer science and engineering with Minsky.
  • Vint Cerf, who worked on ARPAnet in the seventies, and now holds the title of Chief Internet Evangelist at Google, has started talking about what he sees as a need for “digital vellum”: long-term storage. “I worry that the twenty-first century will become an informational black hole,” Cerf e-mailed me. But Kahle has been worried about this problem all along.
  • The Internet Archive is also stocked with Web pages that are chosen by librarians, specialists like Anatol Shmelev, collecting in subject areas, through a service called Archive It, at archive-it.org, which also allows individuals and institutions to build their own archives.
  • Illien told me that, when faced with Kahle’s proposal, “national libraries decided they could not rely on a third party,” even a nonprofit, “for such a fundamental heritage and preservation mission.”
  • screenshots from Web archives have held up in court, repeatedly.
  • Perma.cc has already been adopted by law reviews and state courts; it’s only a matter of time before it’s universally adopted as the standard in legal, scientific, and scholarly citation.
  • It’s not possible to go back in time and rewrite the HTTP protocol, but Van de Sompel’s work involves adding to it. He and Michael Nelson are part of the team behind Memento, a protocol that you can use on Google Chrome as a Web extension, so that you can navigate from site to site, and from time to time. He told me, “Memento allows you to say, ‘I don’t want to see this link where it points me to today; I want to see it around the time that this page was written, for example.’ ”
  • Kent Gerber on 02 Feb 15
     
    Profile of the Internet Archive and the Wayback Machine.
tecno teach

Woodland, J. (2011) Psychology for the classroom: E-Learning. Oxon: Routledge - 4 views

www.routledge.com/...9780415590938

psychology e-learning book

shared by tecno teach on 12 Jan 13 - No Cached
    • tecno teach
      tecno teach on 12 Jan 13
       
      Chapter 4 - Pedagogy Motivation through the possible 'white heat of technology' - the newness. * Emotional engagement *Immediacy * Action Engagement * Cognitive Engagement - see the Hierarchy of Engagement on page 75. * Creative and Critical Thinking - Bono's Six Thinking Hats and Technology * Using VLEs * Social Interaction - Oliver and McLaughlin (1996) proposed five levels of teacher-learner interaction: social, procedural, expository, explanatory and cognitive. * Engagement * Assessment
    • tecno teach
      tecno teach on 12 Jan 13
       
      Chapter 2 - Theory: * Piaget's stages of cognitive development and technologies. * Skiiner's programmed learning theory - technology programmes that are task analysis, sequencing of learning and presentation of concepts through step by step positive reinforcement. * Wenger Communities of Practice * Gilly Salmon (2005) five-step model of levels of maturity in online environments: access and motivation/ online socialisation/ information exchange/ knowledge construction/ learner development. * GBL and Avatars discussed.
    • tecno teach
      tecno teach on 12 Jan 13
       
      Those against technology - Tanya Byron stating they technology is affecting children's minds.
    • tecno teach
      tecno teach on 12 Jan 13
       
      Changing attitudes whilst online - different identities - different ways some converse.
    • tecno teach
      tecno teach on 12 Jan 13
       
      * Motivation of learning - attention, confidence, satisfaction, appreciation and relevance
    • tecno teach
      tecno teach on 12 Jan 13
       
      Key aspects of book of relevance: * explains e-Learning - cybergogy (online pedagogy) * 3 modes of learning - expository, active and interactive * synchronous and asynchronous learning alongside cognitive and social natures of learning
  • cybergogy
  • current research,
  • ...5 more annotations...
  • s illustrative case studies
  • grounding in both theory and pedagogical application
  • behaviourism, cognitivism and constructivism in the context of e-learning.
  • social networking;
  • cybergogy and new learning domains
Randolph Hollingsworth

Ariz State Univ - Service Learning syllabus (USL410 Indep Placement) - 7 views

servicelearning.asu.edu/...10

shared by Randolph Hollingsworth on 07 Sep 12 - No Cached
  • Randolph Hollingsworth on 07 Sep 12
     
    COURSE OBJECTIVES: This is a graded internship that allows you to integrate your own coursework with a hands-on service learning experience. The central objective of this course is to provide students with community experiences and reflection opportunities that examine community needs, the importance of civic engagement, and social justice issues affecting ethnic minorities and marginalized populations in contemporary American society. Students dedicate 70 hours at a pre-approved site (including Title I K-12 schools, youth programs, health services, social services, environmental programs, government agencies, etc.) directly serving a population in need or supporting activities that contribute to the greater good of our community. A weekly seminar, course readings, discussions, and reflection assignments facilitate critical thinking and a deeper understanding of cultural diversity, citizenship, and how to contribute to positive social change in our community. The course is also designed to provide "real-world" experiences that exercise academic skills and knowledge applicable to each student‟s program of study and career exploration. STUDENT LEARNING OBJECTIVES: Student will be introduced to essential skills associated with their baccalaureate studies to actively serve the local community. While completing this in-depth study of cultural diversity, citizenship and social justice issues facing our community, students will gain an understanding of the value of Social Embeddedness and the importance of incorporating civic engagement into their collegiate careers, as they strive to become civically engaged students. Students will be introduced to inequalities, discrimination, and other community issues facing ethnic minorities and marginalized populations, as well as the correlation with greater societal issues. INTERNSHIP RESPONSIBILITIES:  Service hours - 70 hours of community outreach (spread throughout the semester in which you are enrolled in the course)
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