Cold spring Harbor Laboratory's Dolan DNA Learning Center - Harlem DNA Lab & DNA Learning Center West - Glutamate Damage and Stroke - Glutmate Description, transcript - 3D pdf reference and information source
NICHD - National Institute of Health - Eunice Kennedy Shriver National Institute of Child Health & Human Development - Story of Discovery - Research to Prevent Brain Damage in Newborns
NINDS - a Brain-Recording Device that Melts into Place - The technology could pave the way for better devices to monitor and control seizures, and to transmit signals from the brain past damaged parts of the spinal cord.
"These implants have the potential to maximize the contact between electrodes and brain tissue, while minimizing damage to the brain. They could provide a platform for a range of devices with applications in epilepsy, spinal cord injuries and other neurological disorders," said Walter Koroshetz, M.D., deputy director of the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health.
PubMed Study Abstract: Vasoparalysis associated with brain damage in asphyxiated term infants - Dept of Neonatalogy, Rigshospitalet, Copenhagaon, Denmark, 1990
Centers for Disease Control and Prevention CDC 0 Jaundice / Kernicterus - Did you know that jaundice can sometimes lead to brain damage in newborns? - Prevention - Treatment - coping - Free Materials - Frequently Asked Questions and more.
Long-term evaluation of granulocyte-colony stimulating factor on hypoxic-ischemic brain damage in infant rats. Hypoxia-ischemia (HI), as a major cause of fetal brain damage, has long-lasting neurological implications. Therefore, therapeutic interventions that attenuate
the neuropathological out come of HI while also improving the neurofunctional outcome are of paramount clinical importance. The aim of this study was to investigate the long-term functional and protective actions of granulocyte-colony stimulating factor (G-CSF) treatment in an experimental model of cerebral. RESULTS: Granulocyte-colony stimulation promoted somatic growth and prevented brain atrophy and underdevelopment of the heart in infant rats.
NIH PUbMed Abstract of Russian study documenting the Physical and neurological state of the newborn afer perinatal asphyxia.This paper is presented as modern conceptions about asphyxia origin, risk factors, neurological and systemic complications for child nervous system and organism.
In large, multicenter clinical studies, a therapy has been shown to significantly lower the risk of lung and brain damage in some very low birthweight premature infants. Results from two randomized clinical trials demonstrate that when given within the first few weeks of life, inhaled nitric oxide helps prevent chronic lung disease in some low birthweight premature infants. In addition, when used within 48 hours after birth, treatment appears to protect some premature newborns from brain injury.
NINDS - Researchers Identify a Signal for Cell Death during Stroke - In a new study, researchers have identified a signal that promotes the death of vulnerable brain cells in an animal model of stroke. In the future, drugs designed to inhibit this death signal might help reduce brain damage in stroke patients
University of Medicine & Dentistry of New Jersey 2007 Study documents Widespread Repair of Neonatal Brain Injury from Adult Stem Cells - Neuroscientists at UMDNJ-New Jersey Medical School have discovered that the neonatal brain possesses a previously unknown capacity to replace damaged neurons in multiple brain regions. Furthermore, their research reveals that the production of these new neurons lasts for at least five months following injury.Levison's study reveals that in addition to neurons acquiring new or different responsibilities, that another adaptive response, one that has not been suspected, occurs. Their data show that large numbers of new neurons are produced from the brain's resident stem cells during their recovery from injury. These findings suggest that these new neurons are further increasing the infant brain's ability to repair itself after injury.
2010 Study - Increased morbidity in severe early intrauterine growth restriction.CONCLUSIONS: Infants born prematurely who are also severely IUGR have higher neonatal morbidity and mortality when compared to infants of similar gestational age. The surviving IUGR infants had less intraventricular hemorrhage and periventricular leukomalacia than less mature infants of comparable birth weight, but a similar incidence of ROP and length of stay. They had a higher incidence of NEC, direct hyperbilirubinemia and chronic lung disease, probably due to end-organ damage in utero from chronic placental insufficiency. These findings highlight the unique pattern of mortality and morbidity seen in infants with severe early IUGR.
National, non-profit organization whose mission is to accelerate the development of brain repair therapies and cures by supporting cutting-edge collaborative research on brain damage due to childhood illness, injury, or any other cause. Provides information and resources for families and health care providers."
A recent study using high-dose rhEpo (3000 U rhEpo/kg body weight at birth) for neuroprotection in very preterm infants revealed that no signs of adverse effects of early high-dose rhEpo treatment in very preterm infants were identified. Contrary to this, a recent study in PVL of a
rat model revealed that using a low dose rhEpo (50-100 U/kg) was effective in the treatment of brain damage induced by hypoxia-ischemia and did not affect normal oligodendrocyte maturity. On this basis, the researchers intent to investigate (1) whether low-dose rhEpo (100 U/kg) or high-dose rhEpo (3,000 U/kg) given to very preterm infants (gestation age < 32 weeks) immediately after birth and subsequently during the first 2 days is safe and possesses neuroprotective properties;(2) whether there are gender differences in response to the hypoxia-ischemic insult and EPO treatment; (3)the pharmacokinetics of low dose and high dose rhEPO.