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Katelyn Madigan

Tomorrow's life-saving medications may currently be living at the bottom of the sea - 1 views

  • new antibiotics to keep these diseases at bay.
  • Bacteria that live in harmony with animals are a promising source. "
  • bacteria carried by cone snails produce a chemical that is neuroactive,
  • ...2 more annotations...
  • chemicals have promise for treatment of pain
  • "Mollusks with external shells, like the cone snail, were previously overlooked in the search for new antibiotics and other medications
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    Scientists return to previously overlooked sources for new antibiotics and other medications - really portrays the prevalence of antibiotic-resistant microbes.
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    This is great news not only for what we've overlooked, but future implications that deep-sea life has a lot to offer in antibiotics. Another important factor is that we know more about the surface of the moon then our own oceans, so gives us the opportunity and a reason for categorizing deep-sea life.
Katelyn Madigan

Potential novel treatment for influenza discovered: Scientists pursue new therapies as ... - 0 views

  • latest deadly strain of flu, H7N9, is spreading in China -- 82 people in China had been infected with the new strain of flu virus as of April 26, and 17 had died.
  • result of an immune reaction mediated by a protein called Toll-like receptor 4 (TLR4).
  • Currently, vaccines and antiviral medications are the two main approaches to preventing influenza
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    I thought it was interesting that antiviral medications should be administered within two days of infection in order to be effective. This really outlines the need for more effective treatments since this is a very short time frame and there is an increasing resistance to these antiviral therapies in general.
Richard Herron

Child born with HIV cured by US doctors | Society | The Guardian - 0 views

  • Doctors in the US have made medical history by effectively curing a child born with HIV, the first time such a case has been documented.
  • Dr Hannah Gay, who cared for the child at the University of Mississippi medical centre, told the Guardian the case amounted to the first "functional cure" of an HIV-infected child.
  • but it is likely that a tiny amount remains in their body.
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  • ypically, women with HIV are given antiretroviral drugs during pregnancy to minimise the amount of virus in their blood. Their newborns go on courses of drugs too, to reduce their risk of infection further. The strategy can stop around 98% of HIV transmission from mother to child.
    • Richard Herron
       
      I had no idea modern medicine was this effective against transmission from mother to child.
  • "It is far too early for anyone to try stopping effective therapy just to see if the virus comes back," she said.
Casey Finnerty

AAP 2011: Discussing America's Anti-vaccine Movement - 0 views

  • In response to Pushpendra jain's comments... I am no longer amazed of anything in pediatrics. In 15 years of primary care suburban practice I have learned the following: I am an antibiotic nazi especially if i do not treat by telephone request, my medical expertise is compromised by my financial gains or relationships with pharmaceutical companies, my patients' parents do more "research" than I do--AKA reading a google searched internet account, I should be available at their whim and see them at a time convenient to their kid's soccer schedule as a walk-in service, and parents that think nothing of texting while driving their kids to said soccer game think that a 1 in 10,000-100,000 risk of a vaccination obviates its well documented scientific benefits. We are in a cycle where people no longer believe in science, but they'll be back when we see resurgences of diseases i haven't seen since medical school.
  • Dr. Segedy, I can assure you that your sentiments were shared by a majority of the attendees at the AAP conference. It seems as though we have gotten to a point where the element of surprise no longer exists; health care providers (for the most part) are numb to the fact that studies with ulterior motives (ie, Wakefield & vaccines/autism) and "celebrities" seem to have more of an impact on health care decisions than physicians who have dedicated their entire lives studying medicine. And when it comes to self diagnosing via Dr. Google, Offit specifically mentioned that a website like the "National Vaccine Information Center" (NCVIC.org) comes up on the first page of Google for a search for "vaccines" and yet the information on the website is extremely misleading and, in some cases, downright wrong. But that doesn't stop people from treating it as credible; after all, it's on the Internet so it must be true!
Abdirizak Abdi

Using 'Bacteria-Eaters' to Prevent Infections On Medical Implant Materials - 0 views

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    They describe attachment of phages to the surfaces of materials like those used in implanted medical devices, and evidence that the phages remain active, killing E. coli and Staphylococcus aureus. Those bacteria cause the most common hospital-acquired infections.
Katelyn Madigan

Superbugs may have a soft spot, after all - 1 views

  • identified a weakness in at least one superbug that scientists may be able to medically exploit
  • discovered that two proteins already present in E. coli cells -- RbfA and KsgA -- need to be in balance with each other in order for ribosomes to function
  • RbfA does not exist in humans
Casey Finnerty

Infections With 'Nightmare Bacteria' Are On The Rise In U.S. Hospitals : Shots - Health... - 1 views

  • carbapenem-resistant Enterobacteriaceae, or CRE
  • "They're basically a triple threat."
  • they are resistant to virtually all antibiotics
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  • Infectious disease specialist Dr. Brad Spellberg, of the Los Angeles Biomedical Research Institute at the Harbor-UCLA Medical Center, likens the situation to the Titanic's ill-fated voyage. "We're not talking about an iceberg that's down the line," he says. "The ship has hit the iceberg. We're taking on water. We already have people dying. Not only of CRE, but of untreatable CRE."
  • "If CRE spreads out of hospitals and into communities, that's when the ship is totally underwater and we all drown," Spellberg says.
Casey Finnerty

Baby With H.I.V. Is Reported Cured - NYTimes.com - 1 views

  • If the report is confirmed, the child born in Mississippi would be only the second well-documented case of a cure in the world
  • Typically a newborn with an infected mother would be given one or two drugs as a prophylactic measure. But Dr. Gay said that based on her experience, she almost immediately used a three-drug regimen aimed at treatment, not prophylaxis, not even waiting for the test results confirming infection.
  • Virus levels rapidly declined with treatment and were undetectable by the time the baby was a month old. That remained the case until the baby was 18 months old, after which the mother stopped coming to the hospital and stopped giving the drugs.
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  • Dr. Gay contacted Dr. Katherine Luzuriaga, an immunologist at the University of Massachusetts,
  • Dr. Steven Deeks, professor of medicine at the University of California, San Francisco, said if the reservoir never established itself, then he would not call it a true cure, though this was somewhat a matter of semantics. “Was there enough time for a latent reservoir, the true barrier to cure, to establish itself?” he said.
  • One hypothesis is that the drugs killed off the virus before it could establish a hidden reservoir in the baby.
  • They found tiny amounts of some viral genetic material but no virus able to replicate, even lying dormant in so-called reservoirs in the body.
  • “For pediatrics, this is our Timothy Brown,” said Dr. Deborah Persaud, associate professor at the Johns Hopkins Children’s Center and lead author of the report on the baby. “It’s proof of principle that we can cure H.I.V. infection if we can replicate this case.”
  • Dr. Hannah B. Gay, an associate professor of pediatrics,
  • The results have not yet been published in a peer-reviewed medical journal.
  • The baby, born in rural Mississippi, was treated aggressively with antiretroviral drugs starting around 30 hours after birth, something that is not usually done. If further study shows this works in other babies, it will almost certainly be recommended globally.
  • those reports and this new one could suggest there is something different about babies’ immune systems, said Dr. Joseph McCune of the University of California, San Francisco.
  • the results could lead to a new protocol for quickly testing and treating infants.
Tyrell Varner

CDC warning of superbug 'nightmare' - Canon City Daily Record - 0 views

    • Tyrell Varner
       
      This is pretty much exactly what we covered in lecture. I just wonder how far/severe the outcome will be until harsh regulation takes place?
  • Overuse and improper use of antibiotics over the years, both in the medical community and the livestock industry, has led to an increase in the number of bacteria that are drug-resistant.
  • At least 80 percent of antibiotics used annually in the U.S. are used routinely in livestock to promote growth.
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  • Food and Drug Administration
  • banned only one type of antibiotic in livestock and urged the industry to voluntarily limit antibiotic use to promote growth.
Tiffany Arcand

Onions and Flu - Can Raw Onions Prevent the Flu? - Urban Legends - 1 views

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    Although this article does not come from the most scholarly source, my dad and I were talking and he mentioned that if you slice an onion and place it in the corner of the room, it will "absorb" any flu virus present. This is not true.
Elijah Velasquez

Thermo Fisher Scientific launches Brilliance GBS Agar - 1 views

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    The Brilliance GBS Agar is used for the testing of Group B streptococci (GBS) during pregnancy. The new agar is designed to reduce the number of test steps for clinical technicians, give more reliable results, and enable faster patient treatment by featuring proprietary Inhibigen™ technology. In trials, up to 99% of the negatives show no growth, greatly simplifying interpretation. And because the product requires only a single inoculation, it is also ideal for those laboratories who are already automating their test procedures. Screening for GBS can now be as simple as screening for MRSA".
Tiffany Arcand

Medical laboratory and biomedical science: C. difficile outbreak at Ottawa hospital - 0 views

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    The Ottawa Hospital has been severely criticized in a report about practices and hygiene. The report was commissioned following a high number of Clostridium difficile cases over a two year period. This is especially relevant to me because it encompasses both CLS and microbiology.
Amy Jorgenson

Search for new antibiotics advanced by discovery of key processes within bacterial protein - 0 views

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    Scientists have recently discovered how pili are formed, giving another potential target for antimicrobial medications
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    A rather novel discovery in the field of pili biogenesis. This also appears to be a big steeping stone in the development of potential new antibiotics for cystitis (bladder inflammation a.k.a urinary tract infections).
Tiffany Arcand

Medical laboratory and biomedical science: Outbreak of hepatitis A virus infection in f... - 0 views

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    Outbreak of hepatitis A infection in Denmark, Finland, Norway, and Sweden. The exposure is taking place within the countries and may be foodborne from a persistent common source.
Megan Goldman

Researchers Identify Genetic Profile That Predicts Cancer Survival After Chemotherapy ... - 0 views

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    Researchers have identified a biomarker, an eight gene "signature" (a group of genes in a cell whose combined expression is uniquely characteristic of a medical condition), that predicts how long cancer patients might survive without relapse after undergoing chemotherapy. They found that this eight gene signature show a strong correlation to an elevated response to five chemotherapy agents, and showed a lower risk of recurrence and longer relapse-free survival.
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    Curious if this eight gene signature is a result of the genetics of our cell (and resultant interactions) or if it entirely up to the cancerous agent? In simpler terms, are we genetically prone to this eight gene signature or is it luck that our cancer results in this eight gene signature?
Casey Finnerty

Who dares confront the parents of the Bay Area Waldorf School with the 23% vaccination ... - 0 views

  • Rogobo, you make a welcome and important point. But reality is that this topic seems to give rise to insult because it has high stakes (precious cargo on board! kids! death and disease). If you think it's hard to hear a message while people are shouting insults, what's it like being deaf because your mummy got rubella while pregnant? I would put it like this: Notion 1: A world without effective serious infection vaccine is uglier and less pleasant than the alternative (polio, anyone?).  Notion 2: At a population level, vaccines improve outcomes more than they harm them.  Notion 3: At a population level, improved outcomes and the prospect of eradication is dependent on high individual participation. Notion 4: At an individual level, there is some risk associated with vaccination. Notion 5: Healthy people not taking the risks of vaccination are: (a) free riding on those who are taking the risks; (b) reducing the prospect of eradication; (c) increasing the prospect of passing infection to those medically incapable of taking the risk Notion 6: Individual liberty and freedom to choose might sometimes be trumped by requirements of public welfare Happy to have any of those notions challenged and discussed
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