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Nathan Goodyear

Effect of dietary GLA+/−tamoxifen on the growth, ER expression and fatty acid... - 0 views

onlinelibrary.wiley.com/...pdf

GLA breast cancer estrogen receptor positive tamoxifen

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  • Nathan Goodyear on 11 Feb 11
     
    GLA enhances the effectiveness of tamoxifen in the treatment of ER + breast cancer
Nathan Goodyear

Gamma-linolenic acid induces apoptosis in B-chroni... [Leuk Lymphoma. 2001] - PubMed re... - 0 views

www.ncbi.nlm.nih.gov/...11426562

gamma linolenic acid GLA cancer dexamethasone

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  • n the presence of GLA 5 microg/ml and dexamethasone the degree of apoptosis was 86%
  • These results demonstrate that GLA induces apoptosis in B-CLL B- and T-cells cells in vitro and that they are more susceptible to GLA-induced apoptosis than normal peripheral blood B- and T-cells.
  • Nathan Goodyear on 11 Feb 11
     
    GLA, omega-6 found in plant based oils,  kills 42% of leukemia cells; with dexamethasone, the kill rate increases to 86%
Nathan Goodyear

Dietary supplementation with eicosapentaenoic and ... [Int J Cancer. 1998] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...9495237

Omega-3 DHA EPA cancer

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  • t is concluded from the results of the present study that the anti-tumoral effect of EPA is related mainly to its inhibition of cell proliferation, whereas that of DHA corresponds with its induction of apoptosis. The alterations in fatty-acid composition induced by EPA or DHA appear to be factors underlying their differential actions on cell proliferation and apoptosis.
  • Nathan Goodyear on 11 Feb 11
     
    Omega-3, DHA and EPA, work differently in their anti-cancer effects
Nathan Goodyear

The Effect of Dietary Supplementation with n-3 Polyunsaturated Fatty Acids on the Synth... - 0 views

www.nejm.org/...NEJM198902023200501

Omega-3 inflammation anti-inflammatory

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  • Nathan Goodyear on 11 Feb 11
     
    Omega-3 is anti-inflammatory
Nathan Goodyear

(n-3) Fatty Acids and Cancer Therapy - J. Nutr. - 0 views

jn.nutrition.org/...3427S.abstract

Omega-3 cancer

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  • Used alone, an (n-3) supplement may be a useful alternative therapy for patients who are not candidates for standard toxic cancer therapies.
  • Nathan Goodyear on 11 Feb 11
     
    Omega-3 reduce inflammation, inhibit tumor growth, inhibit angiogenesis, induce cancer cell death, and inhibit estrogen signaling
Nathan Goodyear

N-3 and N-6 fatty acids in breast adipose tissue a... [Int J Cancer. 2002] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...11857389

breast cancer omega-3

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  • We found inverse associations between breast cancer-risk and n-3 fatty acid levels in breast adipose tissue
  • In conclusion, our data based on fatty acids levels in breast adipose tissue suggest a protective effect of n-3 fatty acids on breast cancer risk and support the hypothesis that the balance between n-3 and n-6 fatty acids plays a role in breast cancer
  • Nathan Goodyear on 10 Feb 11
     
    Omega-3 lowered breast cancer incidence by 69%
Nathan Goodyear

Induction of antitumor immunity by indomethacin. [Cancer Immunol Immunother. 2000] - Pu... - 0 views

www.ncbi.nlm.nih.gov/...10663608

omega-3 inflammation cancer

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  • Nathan Goodyear on 10 Feb 11
     
    Omega-3 reduce inflammation and suppress cancer growth and metastasis
Nathan Goodyear

Food sources of arachidonic acid (PFA 20:4), listed in descending order by percentages ... - 0 views

riskfactor.cancer.gov/...table4.html

Arachidonic Acid inflammation food

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  • Nathan Goodyear on 10 Feb 11
     
    Food sources of pro-inflammatory Arachidonic Acid
Nathan Goodyear

Inhibitors of Prostaglandin Synthesis Inhibit Human Prostate Tumor Cell Invasiveness an... - 0 views

cancerres.aacrjournals.org/...4629.full

omega-3 prostaglandin inhibitors prostate cancer

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  • Nathan Goodyear on 10 Feb 11
     
    omega-3 reduces aggressiveness of prostate cancer
Nathan Goodyear

Modulation of dietary fat-enhanced colorectal carc... [Nutr Cancer. 1997] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...9383790

dietary fat omega-6 cancer

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  • Nathan Goodyear on 10 Feb 11
     
    Diet high in OMega-6 increases risk of colorectal cancer; increased vegetables reduced risk
Nathan Goodyear

Host and tumor growth and energy substrates in blo... [Am J Clin Nutr. 1988] - PubMed r... - 0 views

www.ncbi.nlm.nih.gov/...3133941

Omega-6 inflammation diet insulin cancer

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  • Nathan Goodyear on 10 Feb 11
     
    Inflammatory Omega-6 diet increase insulin production, which likely will stimulate cancer growth
Nathan Goodyear

Dietary alpha-linolenic acid and immunocompetence in humans - Am J Clin Nutr - 0 views

www.ajcn.org/...40.short

omega-6 cancer immune system

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  • Nathan Goodyear on 10 Feb 11
     
    High omega-6 dietary intake decreases immune system
Nathan Goodyear

Waist Circumference, Waist: Hip Ratio, and Risk of Breast Cancer in the Nurses' Health ... - 0 views

aje.oxfordjournals.org/...1316.short

waist breast circumference cancer risk

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  • These data suggest that greater waist circumference increases risk of breast cancer, especially among postmenopausal women
  • Nathan Goodyear on 10 Feb 11
     
    as waist size increases, so does breast cancer risk
Nathan Goodyear

Dietary fat and mammary cancer. I. Promoting effec... [J Natl Cancer Inst. 1986] - PubM... - 0 views

www.ncbi.nlm.nih.gov/...3459924

dietary fat cancer omega-6

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  • Nathan Goodyear on 10 Feb 11
     
    review of 97 animal studies reveal connection between high omega-6 dietary intake and cancer growth
Nathan Goodyear

Dietary factors and growth and metabolism in experimental tumors - 0 views

www.jnutbio.com/...abstract

omega-6 inflammation tumor cancer dietary

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  • Linoleic acid (LA), an essential n-6 polyunsaturated fatty acid (PUFA), was identified as an agent in dietary fat that is responsible for an up-regulation of tumor growth in vivo
  • Nathan Goodyear on 10 Feb 11
     
    High omega-6 intake in diet increases tumor growth
Nathan Goodyear

Controversial issues of dietary fat and experiment... [Prev Med. 1993] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...8234213

omega-6 inflammation breast cancer

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  • A voluminous amount of information is also available in the literature linking increased fat consumption, particularly polyunsaturated fat, and stimulation of mammary tumorigenesis
  • Nathan Goodyear on 10 Feb 11
     
    diet high omega-6 increases breast cancer metastasis
Nathan Goodyear

Acute local inflammation potentiates tumor growth ... [Cancer Lett. 2000] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...10695986

inflammation Omega-6 cancer

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  • Chronic inflammation in humans has been implicated in the pathogenesis of several types of cancer.
  • These data demonstrate for the first time that an acute, local inflammatory stimuli can induce accelerated tumor growth at the affected site
  • Nathan Goodyear on 10 Feb 11
     
    inflammatory diets, typical American diet high in Omega-6, promote cancer cell growth
Nathan Goodyear

Effects of Alcohol Consumption on Plasma and Urinary Hormone Concentrations in Premenop... - 0 views

jnci.oxfordjournals.org/...722.short

alcohol cancer estrogen pre-menopause

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  • This study has shown increases in total estrogen levels and amount of bioavailable estrogens in association with alcohol consumption in pre-menopausal women.
  • Nathan Goodyear on 10 Feb 11
     
    alcohol increases estrogen production in pre-menopausal women;  implications that alcohol intake increases risk of estrogen sensitive cancers
Nathan Goodyear

Alcohol and Breast Cancer, November 7, 2001, Singletary and Gapstur 286 (17): 2143 - JAMA - 0 views

jama.ama-assn.org/...2143.abstract

breast cancer alcohol

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  • The association of alcohol consumption with increased risk for breast cancer has been a consistent finding in a majority of epidemiologic studies during the past 2 decades
  • Nathan Goodyear on 10 Feb 11
     
    Increased risk of breast cancer in those who regularly consume alcohol; 
Nathan Goodyear

Exploring the Relation of Alcohol Consumption to Risk of Breast Cancer - Am J Epidemiol - 0 views

aje.oxfordjournals.org/...740.full

alcohol cancer

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  • there was a monotonic increase in the relative risk of breast cancer with alcohol consumption
  • Nathan Goodyear on 10 Feb 11
     
    up to 10% increase in breast cancer in women who drink alcohol daily
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