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in title, tags, annotations or urlAscorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo - 0 views
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Proposed mechanism
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The data show that pharmacologic ascorbate concentrations produced Asc•− selectively in extracellular fluid compared with blood and that H2O2 formation occurred when Asc•− concentrations were >100 nM in extracellular fluid.
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These data validate the hypothesis that ascorbate is a prodrug for selective delivery of reactive species to the extravascular space
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Vitamin C preferentially kills cancer stem cells in hepatocellular carcinoma via SVCT-2 | npj Precision Oncology - 0 views
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Chen et al. have revealed that ascorbate at pharmacologic concentrations (0.3–20 mM) achieved only by intravenously (i.v.) administration selectively kills a variety of cancer cell lines in vitro, but has little cytotoxic effect on normal cells.
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Ascorbic acid (the reduced form of vitamin C) is specifically transported into cells by sodium-dependent vitamin C transporters (SVCTs)
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SVCT-1 is predominantly expressed in epithelial tissues
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