Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and h... - 0 views
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Proposed mechanism
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The data show that pharmacologic ascorbate concentrations produced Asc•− selectively in extracellular fluid compared with blood and that H2O2 formation occurred when Asc•− concentrations were >100 nM in extracellular fluid.
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These data validate the hypothesis that ascorbate is a prodrug for selective delivery of reactive species to the extravascular space
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