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low dose HCG, given every other day, shown to maintain intratesticular testosterone levels (ITT) in this with testosterone induced suppression.  A high ITT:T ratio is needed for appropriate spermatogenesis.

Author describes the long-term survival of a man with metastatic pancreatic cancer using IV alpha lipoic acid, low dose naltrexone, diet, and oral triple therapy of milk thistle, ALA, and selenium.  The safety profile is very good as compared to traditional therapy for metastatic pancreatic cancer.

Low dose estrogen therapy to reduce autoinflammatory T cells in rat model with autoimmune encephalomyelitis.

Low dose naltrexone is immune modulator. This study proposes the biochemistry of immune cell suppression through superoxide inhibition.

BPA shown to effect HPA in rats.  The effects were seen as a result of pre and post natal exposure of low dose bisphenol A.  Testosterone was not found to be negatively impacted.  

Small study finds low dose Testosterone, 5 mg over 12 weeks, reduced exercise induce myocardial ischemia through an increase in time to ST segment depression.

low dose naltrexone plus vitamin D3 to treat cancer

low dose naltrexone improves pain control and reduced opioid addiction

low dose exposures of BPA toxic

Percent survival at 1 year was significantly increased in patients treated with immunotherapy than in those treated with supportive care alone (9/25 vs. 3/25, p < 0.05) in study which suggests that low-dose subcutaneous IL-2 plus melatonin may be effective as a second-line therapy to induce tumor regression and to prolong percent survival at 1 year in metastatic colorectal cancer patients progressing under 5-FU and folates

Small phase II pilot sutyd of advanced ovarian cancer, foud low dose IL-2 at 3 million IU/day X 6 days for 4 weeks preceded by 40 mg melatonin provides some benefit in advanced disease following at least 3 failed polychemotherapy regimens.  

Study, again of advanced cancer, with previous failed chemotherapy found that melatonin plus low-dose IL-2 therapy stimulated lymphocyte production and provided a partial response and stable disease.  No control group.

Low-dose, metronomic chemotherapy induces suppression of MDSCs in the TME in glioblastoma.

Great broad review of anti-cancer effects of low-dose metronomic chemotherapy

Low dose IL-2 increases NK cell activity. This is critical in cancer fight.

Good article review on low-dose or fractionated chemotherapy.