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Nathan Goodyear

Melatonin in Cancer Treatment: Current Knowledge and Future Opportunities - PMC - 0 views

www.ncbi.nlm.nih.gov/...PMC8123278

cancer Melatonin

shared by Nathan Goodyear on 12 Aug 22 - No Cached
  • Nathan Goodyear on 12 Aug 22
     
    Melatonin has broad anti-cancer properties.
Nathan Goodyear

Antitumor Activity of Plant Cannabinoids with Emphasis on the Effect of Cannabidiol on Human Breast Carcinoma | Journal of Pharmacology and Experimental Therapeutics - 0 views

jpet.aspetjournals.org/...1375.long

CBD cancer cannabidiol breast cancer cannabinoids

shared by Nathan Goodyear on 19 Oct 22 - No Cached
  • Nathan Goodyear on 19 Oct 22
     
    CBD tops CBG and CBC in anti-breast cancer effects.
Nathan Goodyear

The Anti-aromatase Effect of Progesterone and of its Natural Metabolites 20α- and 5α-Dihydroprogesterone in the MCF-7aro Breast Cancer Cell Line - 0 views

ar.iiarjournals.org/...2129.short

hormones progesterone progesterone metabolites breast cancer cancer 4-pregnenes 20alpha-HSO aromatase

shared by Nathan Goodyear on 07 Oct 16 - No Cached
  • Nathan Goodyear on 07 Oct 16
     
    The progesterone metabolite, 20alpha-dihydroprogesterone, is found to have anti-aromatase activity.  20alphaDHP via the enzyme 20alpha-HSO is a 4-pregnene.
Nathan Goodyear

Antineoplastic Mechanisms of Niclosamide in Acute Myelogenous Leukemia Stem Cells: Inactivation of the NF-κB Pathway and Generation of Reactive Oxygen Species | Cancer Research - 0 views

cancerres.aacrjournals.org/...2516

Niclosamide cancer leukemia NF-kappaB ROS TNF tumor necrosis factor

shared by Nathan Goodyear on 21 Mar 18 - No Cached
  • Here, we report on niclosamide as an antileukemic agent with two independent antineoplastic mechanisms: NF-κB pathway inactivation and ROS generation
  • In this report, we validated the inhibitory action of niclosamide against tumor necrosis factor (TNF)–induced NF-κB activation in AML cells and identified its mechanism, together with generation of reactive oxygen species (ROS), as being responsible for induced apoptosis of AML cells
  • NF-κB plays a critical role in inflammation, antiapoptotic responses, and carcinogenesis
  • ...8 more annotations...
  • pharmacologic inhibition of NF-κB was effective in killing AML cells
  • High NF-κB expression is found in primitive human AML blast cells
  • niclosamide inhibited the TNF-induced NF-κB reporter activity in a dose- and time-dependent manner
  • niclosamide inhibiting TNF-induced IKK phosphorylation (Fig. 2A), niclosamide may exert its inhibitory effect at the TAK1 step
  • Pretreatment with niclosamide completely blocked the time- and dose-dependent TNFα-induced alteration of the NF-κB–DNA complex
  • niclosamide inhibited constitutively active NF-κB binding to DNA in U266 cells
  • niclosamide completely abolished the TNFα-induced phosphorylation of IKKα/β and IκBα
  • Accordingly, the TNFα-induced degradation of IκBα was abrogated by niclosamide
  • Nathan Goodyear on 21 Mar 18
     
    Old anti-parasitic medication, niclosamide, found to have anti-leukemic acitivty through inactivation of NF-kappaB and increase in ROS production in in Vitro and in Vivo study.
Nathan Goodyear

Mechanisms of the anti-cancer and... [Annu Rev Pharmacol Toxicol. 2011] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...20936945

vitamin D inflammation cancer

shared by Nathan Goodyear on 16 Jun 13 - No Cached
  • Nathan Goodyear on 16 Jun 13
     
    Vitamin D inhibits inflammatory signaling and thus useful in cancer therapies.
Nathan Goodyear

Classification of mitocans, anti-cancer drugs acting on mitochondria - 0 views

www.medicinalgenomics.com/...MitoCan.pdf

cancer mitochondria 3-bromopyruvate 3-BrPA

shared by Nathan Goodyear on 11 Sep 13 - No Cached
  • Nathan Goodyear on 11 Sep 13
     
    Good review of therapies directed at mitochondria in cancer.
Nathan Goodyear

Recent developments in mushrooms as anti-cancer therapeutics: a review - 0 views

www.ncbi.nlm.nih.gov/...PMC3339609

cancer mushrooms

shared by Nathan Goodyear on 28 Apr 14 - No Cached
  • Nathan Goodyear on 28 Apr 14
     
    mushrooms and cancer
Nathan Goodyear

Antidepressant Medication Use and Breast Cancer Risk - Am J Epidemiol - 0 views

aje.oxfordjournals.org/...951.abstract

anti antidepressant paxil breast cancer

shared by Nathan Goodyear on 08 Dec 10 - No Cached
  • Nathan Goodyear on 08 Dec 10
     
    Patients on paxil have a 7 fold increase breast cancer risk
Nathan Goodyear

PLoS ONE: Antidepressants and Breast and Ovarian Cancer Risk: A Review of the Literature and Researchers' Financial Associations with Industry - 0 views

www.plosone.org/...journal.pone.0018210

ovarian Cancer breast SSRI anti-depressants Zoloft Paxil Lexapro Prozac

shared by Nathan Goodyear on 24 Jul 11 - No Cached
  • Nathan Goodyear on 24 Jul 11
     
    Antidepressants shown to increase Breast and Ovarian Cancer risk in review of 61 articles. Clear relationship found, but exact risk still needs further research.  Interestingly, the pharmaceutical industry's research, showed no risk.
Nathan Goodyear

High Progesterone Receptor Expression in Prostate Cancer Is Associated with Clinical Failure - 0 views

www.ncbi.nlm.nih.gov/...PMC4344236

prostate cancer progesterone progesterone receptor hormones cancer prostate

shared by Nathan Goodyear on 03 Jun 18 - No Cached
  • Currently, there is a general agreement of PGR presence in the stromal cells of PCa
  • expressed in both stromal and tumor cells of the PCa tissue
  • In univariate analysis, a high density level of PGR in both TE and TS was associated with CF
  • ...17 more annotations...
  • High density level of PGR in the TE was an independent prognostic factor for CF.
  • Our large-sized study demonstrates a wide distribution of PGR in stromal and epithelial cells of both benign and malignant prostate tissue
  • there seems to be a general agreement of PGR presence in the stromal cells of PCa
  • In line with our findings, several have also reported a high PGR expression in TE of PCa [9,10,23,25]. In contrast, others have demonstrated a total lack of PGR expression in TE
  • the actions of progesterone are tissue specific
  • In our work univariate analysis demonstrated a high PGR expression in TS to be associated with clinical failure in PCa patients. So far we have not yet demonstrated the mechanism underlying this association
  • Several non-genomic proliferative actions of progesterone have been proposed in tumor cells of other organs, including breast [35–37], astrocytoma [38] and osteosarcoma [39] cell lines. However, such results are contradicted by suggestions of anti-proliferative actions of progesterone in endometrial cancer
  • Yu et al. found PGR to be negatively regulating stromal cell proliferation in vitro
  • high PGR density level in TE was associated with CF in patients with Gleason score ≥ 7
  • Bonkhoff et al. have suggested progressive emergence of PGR during PCa progression and metastasis
  • Latil and co-workers found a decreased PGR expression in clinically localized tumors and increased PGR expression in hormone-refractory tumors, when compared with normal prostate tissue
  • Our findings provide further support to these findings, indicating that PGR plays a role in the pathogenesis of PCa
  • Ki67 and PGR in TE were correlated with CF (S3 Text), indicating an association between PGR and proliferative activity
  • The mechanism behind the PGR up-regulation in PCa has not yet been elucidated
  • The PGR is, like the glucocorticoid receptor, similar to androgen receptor with 88% sequence homology in the ligand-binding domain
  • progesterone induced expression of androgen receptor-regulated genes could be a potential mechanism contributing to the development of castrate resistant PCa
  • A possibility of different roles by the two PGR isoforms in normal prostate tissue and PCa, as is suggested for the estrogen receptors [13], must also be taken into account
  • Nathan Goodyear on 03 Jun 18
     
    STudy finds that increased Progesterone receptor expression on epithelial and stromal cells is associated with increased clinical failure of therapy.  Several proposed mechanisms: 88% homologous with androgen receptor suggesting cross-stimulation and via progesterone induced increased androgen receptor gene stimulation i.e. epigenetics.
Nathan Goodyear

Anti-angiogenic peptides for cancer therapeutics - 0 views

www.ncbi.nlm.nih.gov/...PMC3114256

cancer angiogenesis peptides

shared by Nathan Goodyear on 29 Aug 20 - No Cached
  • Nathan Goodyear on 29 Aug 20
     
    Peptides to block angiogenesis in the treatment of cancer
Nathan Goodyear

Turning Tumor-Promoting Copper into an Anti-Cancer Weapon via High-Throughput Chemistry - 0 views

www.ncbi.nlm.nih.gov/...PMC3786439

copper cancer Cu Zn

shared by Nathan Goodyear on 06 Oct 21 - No Cached
  • Nathan Goodyear on 06 Oct 21
     
    Cu and cancer and means to lower
Nathan Goodyear

Anti-cancer peptides from ras-p21 and p53 proteins - PubMed - 0 views

pubmed.ncbi.nlm.nih.gov/21728981

PNC27 PNC-28 peptides PNC28 cancer p53 PNC PNC-27

shared by Nathan Goodyear on 14 Aug 21 - No Cached
  • Nathan Goodyear on 14 Aug 21
     
    PNC-27 and 28, contain HDM-2-protein-binding domain sequences from the tumor suppressor p53 to induce pore formation in the membranes of a wide range of cancer cells but not any normal cells tested
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