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Nathan Goodyear

Association of vitamin D status with serum androgen levels in men. - PubMed - NCBI - 0 views

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    vitamin D correlates directly with Testosterone levels, Free Androgen Index, SHBG with a seasonal patter: highest in August and lowest in March.
Nathan Goodyear

Effects of Testosterone Replacement Therapy on Lower Urinary Tract Symptoms: A Systematic Review and Meta-analysis. - PubMed - NCBI - 0 views

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    new meta-analysis finds no negative impact on LUTS with Testosterone therapy in men with low T.
Nathan Goodyear

Estrogenic compounds reduce influenza A virus replication in primary human nasal epithelial cells derived from female, but not male, donors | Lung Cellular and Molecular Physiology - 0 views

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    this is a pdf article only and not much is available for public read: estrogen found to have antiviral activity against influenza A in women via ER-beta activation.
Nathan Goodyear

Effects of Transdermal Testosterone Gel or an Aromatase Inhibitor on Prostate Volume in older men. - PubMed - NCBI - 0 views

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    study finds both Testosterone therapy and aromatase inhibition in men > 65 both increase Testosterone levels.  Increase in prostate size was only seen in the Testosterone only group; not in the AI group.  This implicates aromatase activity in the increase in prostate volume.  
Nathan Goodyear

Effects of Testosterone Replacement on Metabolic and Inflammatory Markers in Men with Opioid-Induced Androgen Deficiency. - PubMed - NCBI - 0 views

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    Opiates and prescription meds are a common cause of low T in men.  In this study with men with metabolic dysfunction and opiate induced low T, Testosterone therapy did not worsen inflammatory/metabolic markers.  Of note, this study did not find improvement in the metabolic and inflammatory markers as other studies have shown.
Nathan Goodyear

Effects of testosterone on neuronal nitric oxide synthase and tyrosine hydroxylase. - PubMed - NCBI - 0 views

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    Testosterone proposed to increase NOS
Nathan Goodyear

THERAPY OF ENDOCRINE DISEASE: Testosterone supplementation and body composition: results from a meta-analysis study. - 0 views

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    new study finds Testosterone therapy in men with low T significantly reduces fat, increases lean muscle mass, and reduces fasting glucose and insulin levels.  Improvements in total cholesterol, triglycerides and HDL was also seen.  Only abstract available currently.
Nathan Goodyear

Nitric oxide mediated erectile activity is a testosterone dependent event: a rat erection model. - PubMed - NCBI - 0 views

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    Only abstract available here, but rat model finds Testosterone increased NO synthase activity in corpora cavernous. 
Nathan Goodyear

Androgen Deprivation Therapy and Future Alzheimer's Disease Risk - 0 views

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    new risk potential for Androgen Deprivation Therapy (ADT) for men with prostate cancer--increased Alzheimer's disease risk.
Nathan Goodyear

Serum androgens and prostate cancer risk: results from the placebo arm of the Prostate Cancer Prevention Trial. - PubMed - NCBI - 0 views

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    study finds no association between total Testosterone, free Testosterone, and 3alpha-andorstanediol glucuronide and prostate cancer.  Included: no association with SHBG and estrogen to Testosterone ratio.
Nathan Goodyear

Prospective longitudinal study of testosterone and incident depression in older men: The Health In Men Study. - PubMed - NCBI - 0 views

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    low Total Testosterone is associated with depression in oder men.
Nathan Goodyear

Effects of aromatase inhibition vs. testosterone in older men with low testosterone: randomized-controlled trial. - PubMed - NCBI - 0 views

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    No surprise that Testosterone therapy improves Testosterone levels in men with low T, but aromatase inhibition (AI) did as well.  In this study, only lean mass increased compared to Testosterone therapy and placebo.  Strength increased in both Testosterone and AI.
Nathan Goodyear

Normalization of testosterone level is associated with reduced incidence of myocardial infarction and mortality in men | European Heart Journal - 0 views

  • In this study of men with low TT levels and without prior MI or stroke, normalization of TT levels using TRT is associated with lower all-cause mortality, fewer MIs, and ischaemic strokes.
  • retrospective study
  • significant benefit is observed only if the dose is adequate to normalize the TT levels
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  • the mechanisms for these effects remain speculative
  • It can be postulated that the beneficial effect of normal T levels on adipose tissue, insulin sensitivity, and lipid profiles or by its anti-inflammatory and anticoagulant properties, as reported by other investigators, might have contributed to our findings
  • off-label use of TRT remains a concern
  • Recent FDA analyses suggest that currently only half of the men on TRT had been diagnosed with hypogonadism
  • 25% of users did not have their T concentrations tested prior to initiating therapy
  • 21% of those prescribed TRT did not have their levels tested at any time during treatment
  • two very recent meta-analyses suggested a lack of convincing evidence posed by TRT.
  • men without a history of previous MI or stroke who have low TT levels, TRT might be associated with decreased risks of MI, ischaemic stroke, and all-cause mortality in long-term follow-up
  • TRT should aim for doses resulting in normalization of TT level as this was shown to be associated with reduction in adverse CV events
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    Testosterone therapy in men with low T to restore physiologic Testosterone levels found to reduce mortality, MI, and stroke risk.
beautybycagla

healthy skin | Get Beauty Tips On - 0 views

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    As we get older, it is importаnt for us to tаke decent cаre of our skin. Exposure to sunlight аnd elements thаt аre distinct cаn wreаk hаvoc on it. This mаy leаd to premаture аging аnd other skin conditions. A skin cаre routine will surely help keep our skin looking fresh, young аnd hydrаted. These аre importаnt steps thаt you need to do аnd so, without further аdo, here is your guide to some bаsic skin cаre routine.
mthlp2019

Modern Times Helpline Pharma - Exporter of Gefitinib Medicines & Erlotinib Tablets from New Delhi - 1 views

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    Gefitinib Medicines, Erlotinib Tablets & Sorafenib Tosylate Exporter offered by Modern Times Helpline Pharma from New Delhi, Delhi, India
Nathan Goodyear

Testosterone replacement therapy and the risk of prostate cancer - 0 views

  • When the level of circulating androgen is below normal, some androgen receptors are inactive, and the secondary downstream effects are decreased. Once androgen receptors within the prostate are saturated, however, increasing testosterone will no longer have an effect
  • the saturation point is thought to occur at low physiologic testosterone levels
  • Only the subset of individuals with pretreatment testosterone level <250 ng dl−1 had PSA level correlating with free and total testosterone level
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  • none of the men stopped testosterone supplementation due to prostate cancer recurrence, and none demonstrated cancer progression
  • PSA level did transiently rise in one patient; however, none exceeded a PSA of 1.5 ng ml−1 to raise concern for biochemical recurrence
  • after 19 months on TRT, 10 hypogonadal patients with a history of undergoing a radical retropubic prostatectomy for prostate cancer had no PSA recurrence and had statistically significant improvements in serum total testosterone and hypogonadal symptoms
  • Similarly, Kaufman and Graydon14 examined case records of seven hypogonadal men who had undergone curative RP with symptoms of hypogonadism and low serum testosterone levels treated with testosterone replacement. No biochemical or clinical evidence of cancer recurrence was noted
  • In a much larger case series, Khera et al.15 reviewed the records of 57 men who received TRT following RP. After an average of 36 months following RP, testosterone replacement was initiated and followed for an average of 13 months. Mean testosterone values rose significantly and once again, there was no increase in PSA values and, therefore, no diagnosed biochemical recurrence
  • Four of the patients in the treatment group were found to have cancer recurrence, compared with eight in the control group
  • All biochemical recurrences were seen in individuals with high-risk disease
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    Good review of data on Testosterone therapy and prostate cancer risk: the take home is there is no increased risk.  Also, included is a discussion of the prostate saturation theory.
Nathan Goodyear

Testosterone administration to men with testosterone deficiency syndrome after external beam radiotherapy for localized prostate cancer: preliminar... - PubMed - NCBI - 0 views

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    small study of men post prostate cancer radiotherapy: only 1 of the 5 had a transient rise in PSA, though the level was still below the 1.5 ng/ml threshold.  This fits within the saturation theory concept. F/u in this study was 14.5 months.  Abstract only available here.
Nathan Goodyear

Liver damage from long-term methyltestosterone. - PubMed - NCBI - 1 views

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    oral methyl Testosterone associated with liver dysfunction and damage. This does not appear to apply to topical or IM Testosterone.  This risk is unique to oral methyl Testosterone.
Nathan Goodyear

Testosterone therapy in hypogonadal men and potential prostate cancer risk: a systematic review - National Library of Medicine - PubMed Health - 0 views

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    meta-analysis finds no evidence of testosterone therapy and increased risk of prostate cancer.
trungtamnamkhoa

Penis enlargement due to where? Cause And Treatment - 1 views

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    The body of the white pimples is a common feature of boys entering puberty. Understanding their nature will help you no longer worry. White pimples on the penis and pores, squeezing out with a white core. Do these acne affect fertility? This top concern in many young people will be answered right after.
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