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Nathan Goodyear

Low-dose human chorionic gonadotropin maintains intratesticular testosterone in normal men with testosterone-induced gonadotropin suppression - 0 views

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    low dose HCG, given every other day, shown to maintain intratesticular testosterone levels (ITT) in this with testosterone induced suppression.  A high ITT:T ratio is needed for appropriate spermatogenesis.
Nathan Goodyear

http://www.integratedhealthclinic.com/assets/byCancerType/Pancreatic/4-LDN%20and%20IV%20Alpha%20Lipoic%20Acid.pdf - 0 views

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    Author describes the long-term survival of a man with metastatic pancreatic cancer using IV alpha lipoic acid, low dose naltrexone, diet, and oral triple therapy of milk thistle, ALA, and selenium.  The safety profile is very good as compared to traditional therapy for metastatic pancreatic cancer.
Nathan Goodyear

Low-Dose Estrogen Therapy Ameliorates Experimental Autoimmune Encephalomyelitis in Two Different Inbred Mouse Strains - 0 views

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    Low dose estrogen therapy to reduce autoinflammatory T cells in rat model with autoimmune encephalomyelitis.
Nathan Goodyear

Naloxone inhibits immune cell function by suppressing superoxide production through a direct interaction with gp91phox subunit of NADPH oxidase - 0 views

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    Low dose naltrexone is immune modulator. This study proposes the biochemistry of immune cell suppression through superoxide inhibition.
Nathan Goodyear

Low dose of bisphenol A impairs the reprod... [J Physiol Biochem. 2013] - PubMed - NCBI - 0 views

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    BPA shown to effect HPA in rats.  The effects were seen as a result of pre and post natal exposure of low dose bisphenol A.  Testosterone was not found to be negatively impacted.  
Nathan Goodyear

Low-Dose Transdermal Testosterone Therapy Improves Angina Threshold in Men With Chronic Stable Angina - 0 views

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    Small study finds low dose Testosterone, 5 mg over 12 weeks, reduced exercise induce myocardial ischemia through an increase in time to ST segment depression.
Nathan Goodyear

http://www.ldnresearchtrust.org/sites/default/files/LDN_Cancer.pdf - 0 views

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    low dose naltrexone plus vitamin D3 to treat cancer
Nathan Goodyear

Oxytrex Minimizes Physical Dependence While Providing Effective Analgesia: A Randomized Controlled Trial in Low Back Pain - 0 views

  • Active treatment groups attained comparable analgesia despite significantly lower drug use
  • preclinical data also show a suppression of opioid tolerance and dependence
  • Previous clinical data have shown ultralow-dose naltrexone enhances and prolongs oxycodone analgesia,
  • ...1 more annotation...
  • A cellular mechanism of action has been demonstrated to be the prevention of aberrant G protein signaling by mu opioid receptors caused by chronic opioid administration
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    low dose naltrexone improves pain control and reduced opioid addiction
Nathan Goodyear

An extensive new literature concerning low-dose ef... [Environ Health Perspect. 2005] - PubMed result - 0 views

  • reports that the median BPA level in human blood and tissues, including in human fetal blood, is higher than the level that causes adverse effects in mice
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    low dose exposures of BPA toxic
Nathan Goodyear

PayPerView: A Randomized Study of Low-Dose Subcutaneous lnterleukin-2 Plus Melatonin versus Supportive Care Alone in Metastatic Colorectal Cancer Patients Progressing under 5-Fluorouracil and Folates - Karger Publishers - 0 views

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    Percent survival at 1 year was significantly increased in patients treated with immunotherapy than in those treated with supportive care alone (9/25 vs. 3/25, p < 0.05) in study which suggests that low-dose subcutaneous IL-2 plus melatonin may be effective as a second-line therapy to induce tumor regression and to prolong percent survival at 1 year in metastatic colorectal cancer patients progressing under 5-FU and folates
Nathan Goodyear

Immunotherapy with subcutaneous low dose interleukin-2 plus melatonin as salvage therapy of heavily chemotherapy-pretreated ovarian cancer - 0 views

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    Small phase II pilot sutyd of advanced ovarian cancer, foud low dose IL-2 at 3 million IU/day X 6 days for 4 weeks preceded by 40 mg melatonin provides some benefit in advanced disease following at least 3 failed polychemotherapy regimens.  
Nathan Goodyear

Immunotherapy with low-dose interleukin-2 in association with melatonin as salvage therapy for metastatic soft tissue sarcomas - 0 views

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    Study, again of advanced cancer, with previous failed chemotherapy found that melatonin plus low-dose IL-2 therapy stimulated lymphocyte production and provided a partial response and stable disease.  No control group.
Nathan Goodyear

Metronomic capecitabine as an immune modulator in glioblastoma patients reduces myeloid-derived suppressor cells - PubMed - 0 views

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    Low-dose, metronomic chemotherapy induces suppression of MDSCs in the TME in glioblastoma.
Nathan Goodyear

Metronomic chemotherapy prevents therapy-induced stromal activation and induction of tumor-initiating cells | Journal of Experimental Medicine | Rockefeller University Press - 0 views

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    Great broad review of anti-cancer effects of low-dose metronomic chemotherapy
Nathan Goodyear

Daily subcutaneous injection of low-dose interleukin 2 expands natural killer cells in vivo without significant toxicity. | Clinical Cancer Research - 0 views

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    Low dose IL-2 increases NK cell activity. This is critical in cancer fight.
Nathan Goodyear

Genetically targeted fractionated chemotherapy - 0 views

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    Good article review on low-dose or fractionated chemotherapy.
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