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Nathan Goodyear

Cancer as a metabolic disease - 0 views

www.biomedcentral.com/...1743-7075-7-7.pdf

cancer

shared by Nathan Goodyear on 17 Jun 13 - No Cached
  • Nathan Goodyear on 17 Jun 13
     
    Dr. Seyfried provides a different perspective on cancer as a metabolic disease and not as a "genetic" disease as is the current dogma. Dr. Seyfried is well published on this topic and presents valid points to show that a ketogenic diet with intermittent fasting is anti-cancer.
Nathan Goodyear

Treatment of pancreatic cancer with intravenous vitamin C: a... : Anti-Cancer Drugs - 0 views

journals.lww.com/...ancer_with_intravenous.10.aspx

metastasis High dose IV vitamin C high dose vitamin C vitamin C IV vitamin C cancer pancreatic cancer

shared by Nathan Goodyear on 09 Mar 21 - No Cached
  • Nathan Goodyear on 09 Mar 21
     
    High dose vitamin C found to be effective in partial regression of pancreatic cancer.
Nathan Goodyear

Chloroquine Inhibits Autophagy to Potentiate Antiestrogen Responsiveness in ER+ Breast Cancer | Clinical Cancer Research - 0 views

clincancerres.aacrjournals.org/...3222.abstract

autophagy inhibitor breast cancer hydroxychloroquine cancer ER+

shared by Nathan Goodyear on 03 May 21 - No Cached
  • Nathan Goodyear on 03 May 21
     
    HCQ restores anti estrogen therapy in ER+ breast cancer.
Nathan Goodyear

The combination of artesunate and carboplatin exerts a synergistic anti-tumour effect on non-small cell lung cancer. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...32072678

cancer chemotherapy artesunate lung cancer

shared by Nathan Goodyear on 12 Apr 20 - No Cached
  • Nathan Goodyear on 12 Apr 20
     
    Artesunate and carboplatin chemotherapy shows synergistic anti-cancer effects.
Nathan Goodyear

Potential enhancement of host immunity and anti-tumor efficacy of nanoscale curcumin and resveratrol in colorectal cancers by modulated electro- hyperthermia | BMC Cancer | Full Text - 0 views

bmccancer.biomedcentral.com/...s12885-020-07072-0

heat shock proteins curcumin HSP70 resveratrol hyperthermia colon cancer

shared by Nathan Goodyear on 25 Feb 21 - No Cached
  • Nathan Goodyear on 25 Feb 21
     
    Local HT augments anti-cancer effects of curcumin and resveratrol.
Nathan Goodyear

NETosis and Neutrophil Extracellular Traps in COVID-19: Immunothrombosis and Beyond - PMC - 0 views

www.ncbi.nlm.nih.gov/...PMC8924116

cancer NETosis SARS-CoV-2 COVID COVID-19 COVID19 platelets

shared by Nathan Goodyear on 18 Apr 23 - No Cached
  • Pneumonia is a typical symptom of COVID-19 infection, while acute respiratory distress syndrome (ARDS) and multiple organ failure are common in severe COVID-19 patients
  • NETs are important for preventing pathogen invasion, their excessive formation can result in a slew of negative consequences, such as autoimmune inflammation and tissue damage
  • SARS-CoV-2 infection has also been linked to increased neutrophil-to-lymphocyte ratios, which is associated with disease severity and clinical prognosis
  • ...40 more annotations...
  • NETosis is a special form of programmed cell death in neutrophils, which is characterized by the extrusion of DNA, histones, and antimicrobial proteins in a web-like structure known as neutrophil extracellular traps (NETs)
    • Nathan Goodyear
      Nathan Goodyear on 23 Apr 23
       
      Definition
  • increased generation of reactive oxygen species (ROS) is a crucial intracellular process that causes NETosis
  • Another indirect route of SARS-CoV-2-induced NET production is platelet activation
  • When NETs are activated in the circulation, they can also induce hypercoagulability and thrombosis
  • In COVID-19, major NET protein cargos of NETs (i.e., NE, MPO, and histones) are significantly elevated.
  • SARS-CoV-2 can also infect host cells through noncanonical receptors such as C-type lectin receptors
  • Immunopathological manifestations, including cytokine storms and impaired adaptive immunity, are the primary drivers behind COVID-19, with neutrophil infiltration being suggested as a significant cause
  • NETosis and NETs are increasingly recognized as causes of vascular injury
  • SARS-CoV-2 and its components (e.g., spike proteins and viral RNA) attach to platelets and increase their activation and aggregation in COVID-19, resulting in vascular injury and thrombosis, both of which are linked to NET formation
    • Nathan Goodyear
      Nathan Goodyear on 23 Apr 23
       
      Connects SARS-CoV-2 to TLR on Platelets to NETosis to metastasis.
  • NET formation may be caused by activated platelets rather than SARS-CoV-2 itself
  • NETosis, leading to aberrant immunity such as cytokine storms, autoimmune disorders, and immunosuppression.
  • early bacterial coinfections were more prevalent in COVID-19 patients than those infected with other viruses
  • NETosis and NETs may also have a role in the development of post COVID-19 syndromes, including lung fibrosis, neurological disorders, tumor growth, and worsening of concomitant disease
    • Nathan Goodyear
      Nathan Goodyear on 23 Apr 23
       
      NETosis-> tumor growth
  • NETs and other by-products of NETosis have been shown to act as direct inflammation amplifiers. Hyperinflammation
  • “cytokine storm”
  • SARS-CoV-2 drives NETosis and NET formation to allow for the release of free DNA and by-products (e.g., elastases and histones). This may trigger surrounding macrophages and endothelial cells to secrete excessive proinflammatory cytokines and chemokines, which, in turn, enhance NET formation and form a positive feedback of cytokine storms in COVID-19
    • Nathan Goodyear
      Nathan Goodyear on 23 Apr 23
       
      Cycle of hyperinflammation
  • NET release enables self-antigen exposure and autoantibody production, thereby increasing the autoinflammatory response
  • patients with COVID-19 who have higher anti-NET antibodies are more likely to be detected with positive autoantibodies [e.g., antinuclear antibodies (ANA) and anti-neutrophil cytoplasmic antibodies (ANCA)]
  • COVID-19 NETs may act as potential inducers for autoimmune responses
  • have weakened adaptive immunity as well as a high level of inflammation
    • Nathan Goodyear
      Nathan Goodyear on 23 Apr 23
       
      Immunomodulation
  • tumor-associated NETosis and NETs promote an immunosuppressive environment in which anti-tumor immunity is compromised
  • NETs have also been shown to enhance macrophage pyroptosis in sepsis
  • facilitating an immunosuppressive microenvironment
  • persistent immunosuppression may result in bacterial co-infection or secondary infection
  • can enhance this process by interacting with neutrophils through toll-like receptor 4 (TLR4), platelet factor 4 (PF4), and extracellular vesicle-dependent processes
  • NET-induced immunosuppression in COVID-19 in the context of co-existing bacterial infection
  • Following initial onset of COVID-19, an estimated 50% or more of COVID-19 survivors may develop multi-organ problems (e.g., pulmonary dysfunction and neurologic impairment) or have worsening concomitant chronic illness
  • NETs in the bronchoalveolar lavage fluid of severe COVID-19 patients cause EMT in lung epithelial cells
  • decreased E-cadherin (an epithelial marker) expression
    • Nathan Goodyear
      Nathan Goodyear on 23 Apr 23
       
      Leads to emt
  • COVID-19 also has a long-term influence on tumor progression
  • Patients with tumors have been shown to be more vulnerable to SARS-CoV-2 infection and subsequent development of severe COVID-19
  • patients who have recovered from COVID-19 may have an increased risk of developing cancer or of cancer progression and metastasis
  • awaken cancer cells
  • NETs have been shown to change the tumor microenvironment
  • enhance tumor progression and metastasis
  • vitamin C has been tested in phase 2 clinical trials aimed at reducing COVID-19-associated mortality by reducing excessive activation of the inflammatory response
  • vitamin C is an antioxidant that significantly attenuates PMA-induced NETosis in healthy neutrophils by scavenging ROS
  • vitamin C may also inhibit NETosis and NET production in COVID-19
  • Metformin
  • Vitamin C
  • Nathan Goodyear on 18 Apr 23
     
    NETosis intimately involved in progressive COVID, long COVID, autoimmunity, and cancer
Nathan Goodyear

Cancer Chemopreventive Activity of Xanthohumol, a Natural Product Derived from Hop 1 Support for this work has been provided by Verein zur Förderung der Krebsforschung in Deutschland e.V. and by Wissenschaftsförderung der Deutschen Brauwirtschaft e.V. The - 0 views

mct.aacrjournals.org/...959.long

xanthohumol antioxidant hops flavonoid cancer

shared by Nathan Goodyear on 03 Jan 13 - No Cached
  • Nathan Goodyear on 03 Jan 13
     
    Xanthohumol, a relatively newly discovered flavonoid from Hops. Xanthohumol has been show to possess anti-tumor activity: anti-inflammatory activity , antioxidant, anti-proliferative activity.
Nathan Goodyear

Metformin as an anti-cancer agent: actions and mechanisms targeting cancer stem cells | Acta Biochimica et Biophysica Sinica | Oxford Academic - 0 views

academic.oup.com/...4371596

Cancer metformin cancer stem cells CSC

shared by Nathan Goodyear on 30 Nov 18 - No Cached
  • Nathan Goodyear on 30 Nov 18
     
    Great review on the multi-prong effect of metformin on cancer cells. Of particular to this article, is the effects on CSCs.
Nathan Goodyear

Update on Programmed Death-1 and Programmed Death-Ligand 1 Inhibition in the Treatment of Advanced or Metastatic Non-Small Cell Lung Cancer - 0 views

www.ncbi.nlm.nih.gov/...PMC5382272

cancer PD-1 immunotherapy programmed death-1

shared by Nathan Goodyear on 20 Apr 18 - No Cached
  • Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), the first immune checkpoint receptor to be clinically targeted, is exclusively expressed on the surface of CD4+ and CD8+ T cells in lymphatic tissue and is involved in T-cell regulation, proliferation, and tolerance
  • programmed death-1 (PD-1) immune checkpoint inhibitor antibodies, which restores T-cell effector function and augments the host anti-tumor response by blocking the binding of either programmed death-ligand 1 (PD-L1) and/or PD-L2 to PD-1 receptors
  • lung cancer is the first and second cause of cancer mortality in men and women
  • ...1 more annotation...
  • Eighty-five percent of lung cancers are non-small-cell lung cancer (NSCLC)
  • Nathan Goodyear on 20 Apr 18
     
    To read update article on PD-1 and immunotherapy.
Nathan Goodyear

Synergy between Paclitaxel and Anti-Cancer Peptide PNC-27 in the Treatment of Ovarian Cancer - PubMed - 0 views

pubmed.ncbi.nlm.nih.gov/28667027

PNC-27 PNC27 peptides ovarian cancer cancer chemotherapy

shared by Nathan Goodyear on 14 Aug 21 - No Cached
  • Nathan Goodyear on 14 Aug 21
     
    PNC-27 found to be adjunctive with weekly paclitaxel in vivo model in ovarian cancer.
Nathan Goodyear

Intraperitoneal Oxidative Stress in Rabbits with Papillomavirus-Associated Head and Neck Cancer Induces Tumoricidal Immune Response That Is Adoptively Transferable | Clinical Cancer Research - 0 views

clincancerres.aacrjournals.org/...4289.long

Ozone cancer COX-2 immunotherapy NK cells NK

shared by Nathan Goodyear on 02 Nov 18 - No Cached
  • Nathan Goodyear on 02 Nov 18
     
    O2-O3 triggers tumoricidal immune response after application of a repetitive highly oxidative stimulus by insufflation of a medical O3/O2 gas mixture into the peritoneal cavity in animal model. O3/O2-PP treatment, indicates an enhanced activation of the innate and adaptive arms of the immune system, implicating a role of activated TILs In the anti cancer effects of the O3. Interestingly, COX2 expression was decreased.
Nathan Goodyear

The onus of cannabinoids in interrupting the molecular odyssey of breast cancer: A critical perspective on UPRER and beyond - 0 views

www.ncbi.nlm.nih.gov/...PMC6438785

breast cancer cancer CBD THC

shared by Nathan Goodyear on 19 Jul 19 - No Cached
  • Nathan Goodyear on 19 Jul 19
     
    Nice review of the anti-cancer benefits of CBD and THC.
Nathan Goodyear

Repurposing Drugs in Oncology (ReDO)-mebendazole as an anti-cancer agent. ecancermedicalscience - 0 views

ecancer.org/...le-as-an-anti-cancer-agent.php

Mebendazole cancer

shared by Nathan Goodyear on 13 Aug 19 - No Cached
  • Nathan Goodyear on 13 Aug 19
     
    Good read on mebendazole's effect in a variety of cancer types.
Nathan Goodyear

Therapeutic hyperthermia: The old, the new, and the upcoming - Critical Reviews in Oncology / Hematology - 1 views

www.croh-online.com/...fulltext

hyperthermia hyperthermic therapy cancer oncology

shared by Nathan Goodyear on 30 Aug 18 - No Cached
  • not well understood, but it is felt to be a combination of both heat-induced necrosis and of protein inactivation (e.g., repair enzymes) as opposed to DNA damage
  • alterations in tumor cytoskeletal and membrane structures, which disrupt cell motility and intracellular signal transduction
  • A common explanation for HT-enhancement of RT and CT involves inhibition of homologous recombination repair of double-strand DNA breaks, preventing cells from repairing sub-lethal damage
  • ...15 more annotations...
  • it does appear to inhibit rejoining of RT-induced DNA breaks more than is commonly observed after RT alone
  • HT damages cells and enhances RT and CT sensitivity as a function of both temperature and duration of treatment
  • as temperature or duration increase, the rate of cell killing also increases
  • At temperatures above 42 °C, tumor vasculature is damaged, resulting in decreased blood flow
  • Cancer cells are particularly vulnerable to heating; in vivo studies have shown that temperatures in the range of 40–44 °C cause more selective damage to tumor cells
  • cancerous blood vessels are chaotic, leaky, and inefficient
  • selective cytotoxic effect on tumor cells include inhibition of key cancer cell-signaling pathways such as AKT, inducing apoptosis, suppression of cancer stem cell proliferation, and others
  • increase in immunological attacks against tumors after HT, which were believed to be achieved through activation of HSPs and subsequent modulation of the innate and adaptive immune responses against tumor cells
  • HT does lead to activation of the immune system and HSP-induced cell death through modification of the tumor cell surface
  • These HSPs and tumor antigens are taken up by dendritic cells and macrophages and go on to induce specific anti-tumor immunity
  • In vivo studies demonstrate HT-enhancement of NK cell activity, and HT has been shown to increase neutrophilic granulocytes with anti-tumor activity
  • it has become increasingly clear that HT results in immune stimulation, through both direct heat-mediated cell killing as well as innate and adaptive immune system modulation
  • The term hyperthermia is used in this review to refer to heating within the clinically accepted range of 40–45 °C
  • temperatures above 42.5–43 °C the exposure time can be halved with each 1 °C increase while maintaining equivalent cell killing
  • gradual heating at 43 °C for 1 h worked through an apoptotic pathway
  • Nathan Goodyear on 30 Aug 18
     
    Comprehensive review of hyperthemic therapy.
Nathan Goodyear

Light at Night, Chronodisruption, Melatonin Suppression, and Cancer Risk: A Review - 0 views

www.researchgate.net/...n-and-Cancer-Risk-A-Review.pdf

Melatonin cancer

shared by Nathan Goodyear on 21 Feb 21 - No Cached
  • Nathan Goodyear on 21 Feb 21
     
    Great review and a must read. Melatonin with broad anti-cancer activity.
Nathan Goodyear

Simultaneous modulation of COX-2, p300, Akt, and Apaf-1 signaling by melatonin to inhibit proliferation and induce apoptosis in breast cancer cells - PubMed - 0 views

pubmed.ncbi.nlm.nih.gov/22335196

cancer melatonin Akt COX-2 breast cancer NF-kappaB

shared by Nathan Goodyear on 27 Aug 20 - No Cached
  • Nathan Goodyear on 27 Aug 20
     
    Melatonin again shown to have broad anti-cancer properties.
Nathan Goodyear

Progesterone Receptor Inhibits Aromatase and Inflammatory Response Pathways in Breast Cancer Cells via Ligand-Dependent and Ligand-Independent Mechanisms - 0 views

mend.endojournals.org/...1812.long

progesterone receptor receptors PR breast cancer anti-inflammatory

shared by Nathan Goodyear on 12 Nov 12 - No Cached
  • Nathan Goodyear on 12 Nov 12
     
    Progesterone receptor (PR) shown to provide an important anti-inflammatory role in breast cancer in this study.  PR shown to increase NF-kappaB inhibitor IkBalpha, shown to inhibit aromatase activity, shown to inhibit COX-2 expression and shown to inhibit HER-2/neu expression.
Nathan Goodyear

Mystery solved of source of anti-cancer effects in pregnancy hormone -- ScienceDaily - 0 views

www.sciencedaily.com/...140623120136.htm

hormone cancer hormones HCG metabolite HIP hCG-like inhibitory products

shared by Nathan Goodyear on 25 Jun 14 - No Cached
  • Nathan Goodyear on 25 Jun 14
     
    Interesting article.  "Small metabolite" of HCG found to provide anti-cancer effect.  The authors called this molecule hCG-like inhibitory Products.  This is very premature information.  
Nathan Goodyear

Dietary supplementation with eicosapentaenoic and ... [Int J Cancer. 1998] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...9495237

Omega-3 DHA EPA cancer

shared by Nathan Goodyear on 11 Feb 11 - No Cached
  • t is concluded from the results of the present study that the anti-tumoral effect of EPA is related mainly to its inhibition of cell proliferation, whereas that of DHA corresponds with its induction of apoptosis. The alterations in fatty-acid composition induced by EPA or DHA appear to be factors underlying their differential actions on cell proliferation and apoptosis.
  • Nathan Goodyear on 11 Feb 11
     
    Omega-3, DHA and EPA, work differently in their anti-cancer effects
Nathan Goodyear

Repurposing Drugs in Oncology (ReDO)-mebendazole as an anti-cancer agent - 0 views

www.ncbi.nlm.nih.gov/...PMC4096024

Mebendazole cancer

shared by Nathan Goodyear on 13 Aug 19 - No Cached
  • Nathan Goodyear on 13 Aug 19
     
    Another repurposed anti-parasite drug in the treatment of cancer.
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