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Nathan Goodyear

A strong association between biologically active testosterone and leptin in non-obese men and women is lost with increasing (central) adiposity - 0 views

www.nature.com/...0801467a.html

leptin Testosterone hormone hormones obesity

shared by Nathan Goodyear on 22 Oct 14 - No Cached
  • strongly supports an association between levels of androgens and leptin in both men and women
  • The association between androgen levels and leptin seems to be dependent of fat distribution in men
  • There is a growing bulk of evidence suggesting that testosterone may influence leptin levels. Testosterone administration reduces leptin levels in hypogonadal27,28 and eugonadal men
  • ...5 more annotations...
  • testosterone suppression by GnRH agonist treatment of central precocious puberty in boys increases leptin levels
  • Testosterone levels decreased with increasing central obesity in healthy men, while they increase with increasing obesity in healthy women, the latter irrespective of menstrual status
  • this could be due to obesity-related hyperleptinemia that inhibits testosterone secretion at the testicular level.46,47 These changes, which are proposed to be components of the insulin resistance syndrome,48 are associated with increased risk for cardiovascular disease in both men and women
  • in the more obese subjects, the higher leptin levels due to increased adiposity might reduce secretion of testosterone
  • loss of regulation of leptin by testosterone in obese men and women could be an important feature of the insulin resistance syndrome
  • Nathan Goodyear on 22 Oct 14
     
    Leptin and Testosterone.  Interesting relationship that differs between the sexes.
Nathan Goodyear

Leptin Resistance: A Possible Interface of Inflammation and Metabolism in Obesity-Related Cardiovascular Disease -- Martin et al. 52 (15): 1201 -- Journal of the American College of Cardiology - 0 views

content.onlinejacc.org/...1201

leptin resistance obesity inflammation

shared by Nathan Goodyear on 12 Apr 11 - No Cached
  • The leptin axis has functional interactions with elements of metabolism, such as insulin, and inflammation, including mediators of innate immunity, such as interleukin-6
  • Given that plasma levels of leptin and inflammatory markers are correlated and also predict cardiovascular risk
  • Nathan Goodyear on 12 Apr 11
     
    leptin resistance, inflammation and obesity
Nathan Goodyear

Obesity - Inducible Toll-like Receptor and NF-[kappa]B Regulatory Pathway Expression in Human Adipose Tissue - 0 views

www.nature.com/...oby200825a.html

TLR-4 TLR Toll-like receptors NF-kapppB inflammation obesity

shared by Nathan Goodyear on 19 Jan 12 - No Cached
  • TLRs are functionally inducible and associated with downstream NF-B activation and proinflammatory cytokine production.
  • TLRs represent a family of receptors that are critical to the innate immune response against foreign pathogens and microorganisms
  • LPS has been shown to induce proinflammatory chemokine gene expression in differentiated human adipocytes through TLR and NF-B action
  • ...2 more annotations...
  • Stimulation of TLRs initiates intracellular signaling cascades resulting in downstream NF-B and mitogen-activated protein kinase activation and production of proinflammatory chemokines associated with mechanisms of metabolic dysfunction and cardiovascular disease progression.
  • Elevated fatty acids levels associated with obesity activate TLR4 signaling in fat cells and macrophages, and induce insulin resistance in murine models
  • Nathan Goodyear on 19 Jan 12
     
    TLR, especially TLR-4, is directly involved in NF-KappaB activation and release of inflammatory cytokines
Nathan Goodyear

Maternal and Cord Steroid Sex Hormones, Angiogenic Factors and Insulin-like Growth Factor Axis in African-American Preeclamptic and Uncomplicated Pregnancies - 0 views

www.ncbi.nlm.nih.gov/...PMC3636811

androgens Testosterone androstenedione women sex hormones cardiovascular disease CVD preeclampsia

shared by Nathan Goodyear on 11 Mar 14 - No Cached
  • Nathan Goodyear on 11 Mar 14
     
    Women with elevated androgens, Testosterone and androstenedione, are at higher risk of preeclampsia.  This translates to a higher risk of CVD in women later in life, post pregnancy.  This fits with other literature that CVD is linearly associated with a rising Testosterone.  This has been found in caucasian and black women.
Nathan Goodyear

Testosterone as Potential Effective Therapy in Treatment of Obesity in Men with Testosterone Deficiency: A Review - 0 views

www.ncbi.nlm.nih.gov/...PMC3296126

Testosterone low T low Testosterone men male hormone hormones obesity cardiovascular disease metabolic syndrome insulin resistance CVD Diabetes

shared by Nathan Goodyear on 23 Jan 15 - No Cached
  • Nathan Goodyear on 23 Jan 15
     
    Testosterone therapy in men with low T will improve lean body mass, some reduction in abdominal obesity, yet little effect in visceral obesity.
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