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Nathan Goodyear

Triptolide inhibits ovarian cancer cell invasion by repression of matrix metalloproteinase 7 and 19 and upregulation of E-cadherin - 0 views

www.ncbi.nlm.nih.gov/...PMC3509180

ovarian cancer triptolide thunder god vine Tripterygium wilfordii matrix metalloproteinase E-cadherin

shared by Nathan Goodyear on 21 Apr 14 - No Cached
  • Nathan Goodyear on 21 Apr 14
     
    Triptolide, a component of thunder god vine (Tripterygium wilfordii) found to counter ovarian cancer through decreased matrix metalloproteinase 7 and 19 as well as increasing E-cadherin. This effect reduces invasion and spread of cancer.
Nathan Goodyear

Estrogens and epithelial ovarian cancer - 0 views

www.sciencedirect.com/...S0090825804001994

cancer ovarian cancer ER alpha ER beta ER-alpha ER-beta estrogen hormones

shared by Nathan Goodyear on 11 Sep 15 - No Cached
  • Nathan Goodyear on 11 Sep 15
     
    ER-alpha >ER-beta expression appears to play role in ovarian carcinogenesis.
Nathan Goodyear

The use of salivary progesterone assays in the assessment of ovarian function in postmenarcheal girls -- Read et al. 102 (2): 265 -- Journal of Endocrinology - 0 views

joe.endocrinology-journals.org/...265

saliva testing salivary

shared by Nathan Goodyear on 22 Nov 10 - No Cached
  • indicate the value of salivary progesterone measurements in studies of ovarian function in adolescence.
  • Nathan Goodyear on 22 Nov 10
     
    The use of salivary progesterone assays in the assessment of ovarian function in postmenarcheal girls
Nathan Goodyear

PLoS ONE: Antidepressants and Breast and Ovarian Cancer Risk: A Review of the Literature and Researchers' Financial Associations with Industry - 0 views

www.plosone.org/...journal.pone.0018210

ovarian Cancer breast SSRI anti-depressants Zoloft Paxil Lexapro Prozac

shared by Nathan Goodyear on 24 Jul 11 - No Cached
  • Nathan Goodyear on 24 Jul 11
     
    Antidepressants shown to increase Breast and Ovarian Cancer risk in review of 61 articles. Clear relationship found, but exact risk still needs further research.  Interestingly, the pharmaceutical industry's research, showed no risk.
Nathan Goodyear

Endogenous androgens and risk of epithelial invasive ovarian cancer by tumor characteristics in the European Prospective Investigation into Cancer and Nutrition - Ose - International Journal of Cancer - Wiley Online Library - 0 views

onlinelibrary.wiley.com/...FD615B31CBA2A30EB588D93.f01t03

ovarian cancer SHBG androgens women female

shared by Nathan Goodyear on 04 Jun 14 - No Cached
  • Nathan Goodyear on 04 Jun 14
     
    prospective study finds that increasing endogenous androgens is associated with low grade epithelial ovarian cancer and inversely associated with high-grade.
Nathan Goodyear

Inflammation in Polycystic Ovary Syndrome: Underpinning of insulin resistance and ovarian dysfunction - 0 views

www.ncbi.nlm.nih.gov/...PMC3309040

PCOS polycystic ovarian syndrome polycystic ovary syndrome insulin resistance inflammation androgens Testosterone women female hormone hormones

shared by Nathan Goodyear on 05 Aug 14 - No Cached
  • Nathan Goodyear on 05 Aug 14
     
    Study points to inflammation causing hyperandrogenism via ovarian theca stimulation.
Nathan Goodyear

Artesunate sensitizes ovarian cancer cells to cisplatin by downregulating RAD51 - 0 views

www.ncbi.nlm.nih.gov/...PMC5391513

artesunate cisplatin chemotherapy cancer ovarian cancer

shared by Nathan Goodyear on 19 Oct 18 - No Cached
  • Nathan Goodyear on 19 Oct 18
     
    artesunate sensitizes ovarian cancer cells to cisplatin.
Nathan Goodyear

High-Dose Parenteral Ascorbate Enhanced Chemosensitivity of Ovarian Cancer and Reduced Toxicity of Chemotherapy - 0 views

stm.sciencemag.org/...222ra18

ovarian cancer IV vitamin C vitamin C intravenous vitamin C

shared by Nathan Goodyear on 06 Feb 14 - No Cached
  • Nathan Goodyear on 06 Feb 14
     
    IV vitamin C shown to augment cancer killer effect of chemotherapy.  This study looked at ovarian cancer in animal models and in humans.  The effect--a synergistic effect was found that promoted tumor destruction.  The great thing about IV vitamin C is the benefit but also the very low side effect profile.
Nathan Goodyear

Meta-Analysis of BRCA1 and BRCA2 Penetrance - 0 views

www.ncbi.nlm.nih.gov/...PMC2267287

BRCA 1 BRCA 2 SNPs single nucleotide polymorphisms cancer breast cancer ovarian cancer

shared by Nathan Goodyear on 18 Sep 17 - No Cached
  • The resulting cumulative risks by age 70 years are as follows: breast cancer risk of 55% (95% CI, 50% to 59%) for BRCA1 and 47% (95% CI, 42% to 51%) for BRCA2 mutation carriers;and ovarian cancer risk of 39% (95% CI,34% to 45%) for BRCA1 and 17% (95% CI,13% to 21%) for BRCA2 mutation carriers
  • Nathan Goodyear on 18 Sep 17
     
    good meta-analysis and discussion of the heterogenous penetrance of BRCA1 and BRCA2.  This study found lower penetrance compared to previous studies i.e. 55% breast cancer risk and 39% ovarian cancer risk in BRCA1
Nathan Goodyear

Human cytomegalovirus in high grade serous ovarian cancer possible implications for patients survival - 0 views

www.ncbi.nlm.nih.gov/...PMC5794372

Cancer "ovarian cancer" CMV cytomegalovirus

shared by Nathan Goodyear on 14 Feb 19 - No Cached
  • Nathan Goodyear on 14 Feb 19
     
    CMV plays role in ovarian cancer. EBV, HPV have shown to play role in other cancers. The likely mechanism is via genetic incorporation of viral genome into the cancer genome.
Nathan Goodyear

In vivo loss-of-function screens identify KPNB1 as a new druggable oncogene in epithelial ovarian cancer | Proceedings of the National Academy of Sciences - 0 views

www.pnas.org/E7301

Ivermectin cancer ovarian cancer oncogene oncogenes

shared by Nathan Goodyear on 20 Mar 18 - No Cached
  • we functionally validated a potent EOC oncogene, KPNB1, and showed its clinical relevance to human EOC
  • a well-established antiparasitic drug, ivermectin, has antitumor effects on EOC through its inhibition of KPNB1
  • EOC has high intertumor and intratumor heterogeneity at the molecular and epigenetic levels
  • ...22 more annotations...
  • the mortality rate of EOC has not been significantly changed for several decades
  • Sequencing revealed that almost all tumors (96%) had mutations in TP53, which serves as a major driver of this cancer
  • Low-prevalence but statistically significant mutations in nine other genes including NF1, BRCA1, BRCA2, RB1, and CDK12 were also identified, but the majority of genes were mutated at low frequency, making it difficult to distinguish between driver and passenger mutations
  • KPNB1 inhibition via any of three KPNB1 siRNAs or importazole treatment induced apoptosis in human EOC cell lines (Fig. 3 A–F and Fig. S4), and was accompanied by an increase in the expression levels of the proapoptotic proteins BAX and cleaved caspase-3
  • Stable overexpression of KPNB1 in SKOV3 and OVCAR3 (Fig. S6) significantly accelerated cell proliferation/survival (Fig. 5 A–C), confirming that KPNB1 functions as an oncogene in EOC
  • KPNB1 overexpression significantly decreased caspase-3/7 activity (Fig. 5D), in addition to the expression levels of cleaved caspase-3 and BAX proteins (Fig. 5E). KPNB1 overexpression also decreased p21 and p27 protein levels (Fig. 5E), as opposed to their increase by KPNB1 inhibition
  • KPNB1 functions as an antiapoptotic and proproliferative oncogene in EOC.
  • Patients with higher expression levels of KPNB1 showed earlier recurrence and worse prognosis than those with lower expression levels of KPNB1
  • KPNB1 acts as an oncogene in human EOC and represents a promising therapeutic target.
  • ivermectin treatment suppressed cell proliferation/viability in a dose-dependent manner (Fig. 7A), indicating that it exerts an antitumor effect on EOC
  • ivermectin also induced apoptosis
  • ivermectin increased the expression levels of BAX, and cleaved PARP, as well as p21 and p27
  • KPNB1 inhibition is responsible for the antitumor effect of ivermectin
  • we found that ivermectin synergistically reduced cell proliferation/viability in combination with paclitaxel in human EOC cells
  • Single treatment of ivermectin or paclitaxel reduced tumor growth in nude mice, but, notably, combination treatment of ivermectin and paclitaxel almost completely suppressed tumor growth
  • ERBB2, is amplified and overexpressed in many cancers, including breast (31), ovary (31), colon (32), bladder (33), non-small-cell lung (34), and gastric cancer (35), and is a poor prognostic factor in certain cancer types
  • KPNB1 was the second-highest-ranked gene identified in our screen
  • Increased KPNB1 protein levels have been reported in several cancers, including cervical cancer (42), hepatocellular carcinoma (43), and glioma (44), suggesting KPNB1’s oncogenic potential in these tumor types
  • our findings suggest that KPNB1 might serve as a master regulator of cell cycle by regulating several cell cycle-related proteins, including p21, p27, and APC/C family members
  • higher and/or more-frequent doses of ivermectin than currently approved for humans are well tolerated in humans
  • none of the mice in this study treated with the effective dosage of ivermectin for in vivo anticancer therapy showed severe adverse event
  • we found that the combination of ivermectin and paclitaxel produces a stronger antitumor effect on EOC cell lines than either drug alone
  • Nathan Goodyear on 20 Mar 18
     
    Ivermectin found to be pro-apoptotic for the epithelial ovarian cancer oncogene, KPNB1 in in Vivo study.  This effective anti-parasitic drug inhibits the KPNB1 oncogene.
Nathan Goodyear

High-dose parenteral ascorbate enhanced chemosensitivity of ovarian cancer and reduced toxicity of chemotherapy. - PubMed - NCBI - 1 views

www.ncbi.nlm.nih.gov/...24500406

cancer ovarian cancer ascorbic acid IV vitamin C IV vitamin C dosing vitamin C chemotherapy

shared by Nathan Goodyear on 22 Jan 18 - No Cached
  • Nathan Goodyear on 22 Jan 18
     
    Proof of conept finds IV vitamin C is synergistic with chemotherapy in ovarian cancer.  In addition, a reduction in toxic side effects were also seen.  Why is vitamin C not used???  The results were found in in vivo and in vitro study.
Nathan Goodyear

Immunotherapy with subcutaneous low dose interleukin-2 plus melatonin as salvage therapy of heavily chemotherapy-pretreated ovarian cancer - 0 views

www.spandidos-publications.com/...947

cancer IL-2 immunotherapy melatonin ovarian cancer

shared by Nathan Goodyear on 10 May 18 - No Cached
  • Nathan Goodyear on 10 May 18
     
    Small phase II pilot sutyd of advanced ovarian cancer, foud low dose IL-2 at 3 million IU/day X 6 days for 4 weeks preceded by 40 mg melatonin provides some benefit in advanced disease following at least 3 failed polychemotherapy regimens.  
Nathan Goodyear

The Efficacy of Radiofrequency Hyperthermia Combined with Chemotherapy in the Treatment of Advanced Ovarian Cancer - 0 views

www.ncbi.nlm.nih.gov/...PMC5984478

hyperthermia pain chemotherapy ovarian cancer

shared by Nathan Goodyear on 25 Jan 21 - No Cached
  • Nathan Goodyear on 25 Jan 21
     
    Hyperthermia + chemotherapy found to be effective in advanced ovarian cancer, including improvement in pain control.
Nathan Goodyear

Artesunate promotes Th1 differentiation from CD4+ T cells to enhance cell apoptosis in ovarian cancer via miR-142 - 0 views

www.ncbi.nlm.nih.gov/...PMC6489539

ovarian cancer cancer apoptosis T cells artesunate

shared by Nathan Goodyear on 23 May 19 - No Cached
  • Nathan Goodyear on 23 May 19
     
    Artesunate found to promote T cell differentiation to increase apoptosis of ovarian cancer cells in a murine model.
Nathan Goodyear

Anti-Cancer Tumor Cell Necrosis of Epithelial Ovarian Cancer Cell Lines Depends on High Expression of HDM-2 Protein in Their Membranes - PubMed - 0 views

pubmed.ncbi.nlm.nih.gov/33067207

ovarian cancer peptides cancer PNC27 PNC-27 HDM-2

shared by Nathan Goodyear on 14 Aug 21 - No Cached
  • Nathan Goodyear on 14 Aug 21
     
    PNC-27 binds to HDM-2 which is highly expressed on ovarian cancer cancer cell lines. The result is transmembrane pore formation and apoptosis independent cell necrosis.
Nathan Goodyear

Synergy between Paclitaxel and Anti-Cancer Peptide PNC-27 in the Treatment of Ovarian Cancer - PubMed - 0 views

pubmed.ncbi.nlm.nih.gov/28667027

PNC-27 PNC27 peptides ovarian cancer cancer chemotherapy

shared by Nathan Goodyear on 14 Aug 21 - No Cached
  • Nathan Goodyear on 14 Aug 21
     
    PNC-27 found to be adjunctive with weekly paclitaxel in vivo model in ovarian cancer.
Nathan Goodyear

Ovarian hormones and reproductive risk factors for breast cancer in premenopausal women: the Norwegian EBBA-I study - 0 views

humrep.oxfordjournals.org/...1519.full

estradiol progesterone estrogen hormone hormones saliva salivary testing breast Cancer Norwegian EBBA-I study Norwegian

shared by Nathan Goodyear on 14 Nov 12 - No Cached
  • Nathan Goodyear on 14 Nov 12
     
    this study looked at ovarian sex hormones as it relates to premenopausal women and breast cancer risk.  They used saliva as the test medium to evaluate estradiol and progesterone.
Nathan Goodyear

Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice - 0 views

www.pnas.org/...11105.full

IV vitamin C vitamin C ovarian cancer pancreatic cancer glioblastoma cancer

shared by Nathan Goodyear on 26 May 13 - Cached
  • Nathan Goodyear on 26 May 13
     
    high dose IV vitamin C shown to be treatment option in Cancer.  Granted in a mouse study, but high dose IV vitamin C shown to decrease growth rates of ovarian, pancreatic, and glioblastoma cancers.
Nathan Goodyear

Glutathione S-transferase activity in epithelial ovarian cancer: Association with response to chemotherapy and disease outcome - 0 views

annonc.oxfordjournals.org/...343

glutathione glutathione-S-transferase GST ovarian ovarian cancer cancer chemotherapy disease

shared by Nathan Goodyear on 30 Jan 13 - No Cached
  • Nathan Goodyear on 30 Jan 13
     
    higher glutathione S-transferase activity associated with improved survival and response with chemotherapy.
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