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Nathan Goodyear

Sensory Processing Disorder in a Primate Model: Evidence From a Longitudinal Study of P... - 0 views

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    Good discussion of sensory processing disruption, dopamine, and BDNF.  This study specifically looked at a monkey model.
Nathan Goodyear

MedLink - 0 views

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    Mercury exposure associated with polyneuropathy. Sensory is more recent exposure with long term exposure associated with motor.
Nathan Goodyear

Sensory Neuropathy from Pyridoxine Abuse - NEJM - 0 views

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    older study.  High dosage vitamin B6 associated with short term ataxia and and neuropathy.  This resolved following removal.   Dosage unknown.
Nathan Goodyear

Mitochondrial dysfunction in distal axons contributes to human immunodeficiency virus s... - 0 views

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    mitochondrial damage associated with neuropathy
Nathan Goodyear

Severe sensory motor polyneuropathy at the onset of diabetes mellit... - PubMed - NCBI - 0 views

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    only abstract available.  Testosterone therapy involved in the resolution of polyneuropathy in new onset Diabetes.
Nathan Goodyear

Hyperbaric oxygen therapy promotes neurogenesis: where do we stand? - 0 views

  • Numerous in vivo and in vitro studies confirm that HBOT induces neurogenesis
  • HIF-1α is the principal mediator of cellular hypoxia adaptations
  • activated by hypoxia, HIF-1α causes the transcription of its regulated downstream genes, including erythropoietin (EPO) and VEGF which are known to promote neurogenesis
  • ...10 more annotations...
  • The safety of HBOT was also evaluated and it was pointed out that, if given at proper paradigms, like 1.5 ATA for 60 minutes, HBOT will not cause oxygen toxicity
  • Rockswold et al., on the other hand, found that HBOT might be potentially beneficial for severe TBI patients
  • McDonagh et al., concluded that there was insufficient evidence to establish the effectiveness of HBOT in the treatment of TBI
  • The first multicenter, randomized, double-blind, controlled trial in 2009 found that 40-hour HBOT of 24% oxygen at 1.3 ATM produced significant improvement in children's overall functioning, receptive language, social interaction, eye contact, and sensory/cognitive awareness compared to those received slightly pressurized room air
  • Another study in 2010 on 16 autism patients, adopting a similar treatment paradigm, showed no effect on a wide array of behavioral evaluations
  • To date, there is little evidence that HBOT causes malignant growth or metastasis. A history of malignancy should therefore not be considered as a contraindication for HBOT
  • HBOT enhances the production of reactive oxygen species (ROS) and causes oxidative stress in body tissues
  • Excessive accumulation of oxidative stress may contribute to neurodegenerative processes and cell death in the brain, as seen in diseases like Alzheimer's disease (AD) and Parkinson's disease (PD)
  • Hormesis
  • process that results in a functional improvement of cellular stress resistance, survival, and longevity in response to sub-lethal levels of stress
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    great review of hbot, brain injury, neuroplasticity and neurogenesis.
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