Group items tagged prostatitis - Dr. Goodyear

<i>Artesunate</i> Suppresses the Growth of Prostatic Cancer Cells through Inhibiting An... - 0 views

www.jstage.jst.go.jp/...en

artesunate prostate cancer

shared by Nathan Goodyear on 03 Jun 19 - No Cached

Nathan Goodyear on 03 Jun 19

Artesunate found to have broad range of anti-cancer activity, such as pro-apoptosis attenuation of tumor growth, metastasis, and angiogenesis. This study primarily looked at the effect in a prostate cancer mouse model. It found that the artesunate down regulated androgen receptors. Now, there is debate about how and when AR and androgens play a role in prostate cancer as studies have also pointed to estrogen and ER in carcinogenesis of the prostate.

<div class="cArrow"> </div><div class="cContentInner">Artesunate found to have broad range of anti-cancer activity, such as pro-apoptosis attenuation of tumor growth, metastasis, and angiogenesis. This study primarily looked at the effect in a prostate cancer mouse model. It found that the artesunate down regulated androgen receptors. Now, there is debate about how and when AR and androgens play a role in prostate cancer as studies have also pointed to estrogen and ER in carcinogenesis of the prostate.</div>

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Effect of Finasteride on the Sensitivity of PSA for Detecting Prostate Cancer - 0 views

jnci.oxfordjournals.org/...1128.long

PSA prostate BPH prostate cancer 5 alpha reductase finasteride male hormones men

shared by Nathan Goodyear on 14 Oct 15 - No Cached

Nathan Goodyear on 14 Oct 15

Finasteride more likely to lower PSA associated with benign prostate conditions compared to cancer of prostate.

<div class="cArrow"> </div><div class="cContentInner">Finasteride more likely to lower PSA associated with benign prostate conditions compared to cancer of prostate.</div>

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Selenomethionine and α-Tocopherol Do Not Inhibit Prostate Carcinogenesis in t... - 0 views

cancerpreventionresearch.aacrjournals.org/...371.long

prostate cancer prostate cancer estrogen estradiol male hormones

shared by Nathan Goodyear on 18 Nov 16 - No Cached

Nathan Goodyear on 18 Nov 16

In this animal study, estradiol is added to Testosterone to increase prostate carcinogenesis. Previous rat studies have shown that adding estradiol to Testosterone, which occurs naturally, increases prostate cancer risk.

<div class="cArrow"> </div><div class="cContentInner">In this animal study, estradiol is added to Testosterone to increase prostate carcinogenesis. Previous rat studies have shown that adding estradiol to Testosterone, which occurs naturally, increases prostate cancer risk. </div>

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Matrix metalloproteinases in the pathogenesis of estradiol-induced nonbacterial prostat... - 0 views

www.mendeley.com/...teral-prostate-lobe-wistar-rat

prostate estradiol E2 testosterone T DHT inflammation

shared by Nathan Goodyear on 01 May 12 - No Cached

Nathan Goodyear on 01 May 12

In rat model, Estradiol shown to increase inflammation in lateral lobes of the prostate. Androgens, Testosterone > DHT, shown to inhibit this inflammatory response.

<div class="cArrow"> </div><div class="cContentInner">In rat model, Estradiol shown to increase inflammation in lateral lobes of the prostate. Androgens, Testosterone > DHT, shown to inhibit this inflammatory response. </div>

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The role of androgens and estrogens in the pathogenes... [J Urol. 1988] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...3172358

prostatitis E2 estradiol testosterone T:E2 testosterone:Estradiol aromatase inhibitors

shared by Nathan Goodyear on 01 May 12 - No Cached

Testosterone can block the effect of estradiol on prostatitis, however treatment with an anti-estrogen or an aromatase inhibitor to block estrogen action does not improve prostatitis in the rat
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Nathan Goodyear on 01 May 12

Estradiol and imbalanced Testosterone:Estradiol ratio contributes to prostatitis. In this study, with rats, aromatase inhibitors did not improve prostatitis.

<div class="cArrow"> </div><div class="cContentInner">Estradiol and imbalanced Testosterone:Estradiol ratio contributes to prostatitis. In this study, with rats, aromatase inhibitors did not improve prostatitis.</div>

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Immunohistochemical evidence of the existence and localization of aromatase in human pr... - 0 views

onlinelibrary.wiley.com/...abstract

aromatase aromatase inhibitor prostate inflammation Testosterone Estradiol

shared by Nathan Goodyear on 15 May 12 - No Cached

Nathan Goodyear on 15 May 12

aromatase activity is present in the prostate. The conversion of Testosterone to Estradiol via aromatase activity has been shown to contribute to inflammation and prostate enlargement.

<div class="cArrow"> </div><div class="cContentInner">aromatase activity is present in the prostate. The conversion of Testosterone to Estradiol via aromatase activity has been shown to contribute to inflammation and prostate enlargement.</div>

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Testosterone and prostate safety. [Front Horm Res. 2009] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...19011298

testosterone prostate therapy treatment prostate cancer low T low testosterone men hormone hormones

shared by Nathan Goodyear on 05 Jul 12 - No Cached

Nathan Goodyear on 05 Jul 12

Testosterone therapy is safe for the prostate. In fact, low T is associated with increased risk of prostate cancer.

<div class="cArrow"> </div><div class="cContentInner">Testosterone therapy is safe for the prostate. In fact, low T is associated with increased risk of prostate cancer. </div>

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Prostate cancer risk in testoster... [J Steroid Biochem Mol Biol. 2006] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...17113983

Testosterone treatment therapy prostate prostate cancer testosterone deficiency men hormone hormones cancer

shared by Nathan Goodyear on 05 Jul 12 - No Cached

In hypogonadal men who were candidates for testosterone therapy, a 14% incidence of occult cancer was found
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Data from all published prospective studies on circulating level of total and free testosterone do not support the hypothesis that high levels of circulating androgens are associated with an increased risk of prostate cancer
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Indeed, high-grade prostate cancer has been associated with low plasma level of testosterone.
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Nathan Goodyear on 05 Jul 12

testosterone therapy does not increase prostate cancer.

<div class="cArrow"> </div><div class="cContentInner">testosterone therapy does not increase prostate cancer.</div>

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Estrogen Receptor {beta}: Switching to a New Partner and Escaping from Estrogen -- Leun... - 0 views

stke.sciencemag.org/...pe19

estrogen estradiol estrone E2 E1 ER-alpha ER-beta BPH prostate cancer inflammation apoptosis men male receptors

shared by Nathan Goodyear on 18 Sep 12 - No Cached

Nathan Goodyear on 18 Sep 12

Study shows that estradiol decreases ER beta in the prostate. ER beta is anti-inflammatory, inhibits growth, and promotes cell death: all of which would decrease risk of prostate growth and/or cancer. We know that men increase estrogen production through increased aromatase activity, which according to this study, will decrease ER beta and the prostate associated benefits.

<div class="cArrow"> </div><div class="cContentInner">Study shows that estradiol decreases ER beta in the prostate. ER beta is anti-inflammatory, inhibits growth, and promotes cell death: all of which would decrease risk of prostate growth and/or cancer. We know that men increase estrogen production through increased aromatase activity, which according to this study, will decrease ER beta and the prostate associated benefits.</div>

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CpG hypermethylation of the promoter region inactivates the estrogen receptor... - 0 views

onlinelibrary.wiley.com/...full

prostate cancer ER beta ER-beta estrogen methylation BPH benign prostatic hypertrophy

shared by Nathan Goodyear on 21 Jan 14 - No Cached

Nathan Goodyear on 21 Jan 14

ER beta expression that is lost in prostate carcinogenesis occurs via methylation at the ER beta gene promoter sites 19CpG. What is really interesting is that ER beta expression was present in all of the samples with BPH, but was absent in 83% of the prostate cancer samples.

<div class="cArrow"> </div><div class="cContentInner">ER beta expression that is lost in prostate carcinogenesis occurs via methylation at the ER beta gene promoter sites 19CpG. What is really interesting is that ER beta expression was present in all of the samples with BPH, but was absent in 83% of the prostate cancer samples.</div>

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Effects of androgens on telomerase activity in normal and malignant prostate cells in v... - 0 views

onlinelibrary.wiley.com/...AC2C88175F4E55359BA67DC.f03t03

androgen deprivation therapy Prostate cancer androgen deprivation therapy Testosterone Telomerase Telomere length

shared by Nathan Goodyear on 10 Jan 14 - No Cached

Nathan Goodyear on 10 Jan 14

Androgen deprivation therapy reduces Telomerase activity in androgen dependent prostate cancer cell lines. Conversely, Testosterone increases Telomerase activity. In these cell lines Telomerase activity is positively associated with prostate cancer.

<div class="cArrow"> </div><div class="cContentInner">Androgen deprivation therapy reduces Telomerase activity in androgen dependent prostate cancer cell lines. Conversely, Testosterone increases Telomerase activity. In these cell lines Telomerase activity is positively associated with prostate cancer.</div>

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Frequent Loss of Estrogen Receptor-β Expression in Prostate Cancer - 0 views

cancerres.aacrjournals.org/...5331.full

ER beta ER-beta prostate cancer prostate cancer estrogen hormones

shared by Nathan Goodyear on 11 Sep 15 - No Cached

Nathan Goodyear on 11 Sep 15

loss of ER-beta expression in the prostate is associated with increased prostate carcinogenesis.

<div class="cArrow"> </div><div class="cContentInner">loss of ER-beta expression in the prostate is associated with increased prostate carcinogenesis.</div>

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Phase II Study of Pomegranate Juice for Men with Rising Prostate-Specific Antigen follo... - 0 views

clincancerres.aacrjournals.org/...4018.abstract

Pomegranate Prostate cancer

shared by Nathan Goodyear on 01 Mar 11 - No Cached

n vitro assays comparing pretreatment and posttreatment patient serum on the growth of LNCaP showed a 12% decrease in cell proliferation and a 17% increase in apoptosis (P = 0.0048 and 0.0004, respectively), a 23% increase in serum nitric oxide (P = 0.0085), and significant (P < 0.02) reductions in oxidative state and sensitivity to oxidation
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Nathan Goodyear on 01 Mar 11

Pomegranate beneficial for Prostate health and Prostate Cancer

<div class="cArrow"> </div><div class="cContentInner">Pomegranate beneficial for Prostate health and Prostate Cancer</div>

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XMRV is present in malignant prostatic epithelium and is associated with prostate cance... - 0 views

www.ncbi.nlm.nih.gov/...PMC2739868

prostate cancer virus cancer

shared by Nathan Goodyear on 03 Oct 18 - No Cached

Nathan Goodyear on 03 Oct 18

Is prostate cancer, in part, a result of viral insult. Study finds XMRV is highly associated with high-grade prostate cancer.

<div class="cArrow"> </div><div class="cContentInner">Is prostate cancer, in part, a result of viral insult. Study finds XMRV is highly associated with high-grade prostate cancer.</div>

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Men with Low Serum Cholesterol Have a Lower Risk of High-Grade Prostate Cancer in the P... - 0 views

cebp.aacrjournals.org/...2807

cholesterol cancer prostate cancer

shared by Nathan Goodyear on 30 May 18 - No Cached

Nathan Goodyear on 30 May 18

not really much can be gleamed from this other than lower cholesterol i.e. < 200 is associated with high grade, gleason 8-10, prostate cancer. No association was found with prostate cancer in general.

<div class="cArrow"> </div><div class="cContentInner">not really much can be gleamed from this other than lower cholesterol i.e. < 200 is associated with high grade, gleason 8-10, prostate cancer. No association was found with prostate cancer in general.</div>

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Bisphenol A Effects on Estrogen Receptor β Expression: Implications in Prosta... - 0 views

www.niehs.nih.gov/...index.cfm

BPA bisphenol A ER-beta prostate estrogen receptors ER estrogen receptors cancer

shared by Nathan Goodyear on 21 Nov 12 - No Cached

Nathan Goodyear on 21 Nov 12

Bisphenol A downgregulates ER-beta in male prostate. This would increase pro-inlfmmatory/growth through ER-alpha theoretically and has implications in prostate health.

<div class="cArrow"> </div><div class="cContentInner">Bisphenol A downgregulates ER-beta in male prostate. This would increase pro-inlfmmatory/growth through ER-alpha theoretically and has implications in prostate health.</div>

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Comparative studies of the estrogen receptors be... [Am J Pathol. 2001] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...11438457

ER beta prostate cancer prostate cancer estrogen receptor estrogen receptor hormone hormones

shared by Nathan Goodyear on 05 Feb 13 - No Cached

Nathan Goodyear on 05 Feb 13

loss of ER beta in the prostate associated with increased prostate cancer.

<div class="cArrow"> </div><div class="cContentInner">loss of ER beta in the prostate associated with increased prostate cancer.</div>

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The role of 5-alpha reductase inhibitors in prostate pathophysiology: Is there an addit... - 1 views

www.ncbi.nlm.nih.gov/...PMC2698784

prostate 5 alpha reductase 5 alpha reductase inhibitors hormones male men male hormones

shared by Nathan Goodyear on 01 Jul 16 - No Cached

Nathan Goodyear on 01 Jul 16

good review of 5-alpha reductase inhibitor and prostate pathophysiology. Type I is increased in prostate cancer.

<div class="cArrow"> </div><div class="cContentInner">good review of 5-alpha reductase inhibitor and prostate pathophysiology. Type I is increased in prostate cancer. </div>

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Urological Research, Volume 15, Number 3 - SpringerLink - 0 views

www.springerlink.com/...r414480g0m356293

aromatase aromatase inhibitor estrogen men prostatitis BPH prostate cancer

shared by Nathan Goodyear on 02 May 12 - No Cached

Nathan Goodyear on 02 May 12

aromatization of androstenedione to estrogen shown to play role in prostatitis, BPH, and prostate cancer. In this study, they looked at aromatase inhibition to slow this process.

<div class="cArrow"> </div><div class="cContentInner">aromatization of androstenedione to estrogen shown to play role in prostatitis, BPH, and prostate cancer. In this study, they looked at aromatase inhibition to slow this process.</div>

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The Dual, Opposing Roles of Estrogen in the Prostate - Ellem - 2009 - Annals of the New... - 0 views

onlinelibrary.wiley.com/...30E32040B060F42071BE703.d02t04

estrogen prostate ER-alpha ER-beta androgens men