mice study suggests that increased linoleic acid increases lipid oxidation and increases metabolic rate and muscle performance. The point is that some fat is good. Too much Linoleic acid is pro-inflammatory which would promote adiposity. The key is balance.
Palmitoleic acid and estimated D6D activity found to positively correlate with diabetes and worsening glucose control; In contrast, linoleum acid found to be inversely associated with glucose control and Diabetes development.
The polyunsaturated fatty acids linoleic (LA, 18:2n-6) and linolenic acid (LNA, 18:3n-3) are essential fatty acids that cannot be synthesized by the body.
LNA serves as the precursor for long chain omega-3 fatty acids such as docosahexaenoic acid (DHA) while LA is converted into long chain omega-6 fatty acids such as arachidonic acid (AA)
DHA and AA are abundantly found in the brain, where these are stored mainly in membrane phospholipids
DHA has been shown to increase neurite outgrowth and synaptogenesis, and promotes glutamatergic neurotransmission through increase in glutamate receptor subunit expression
DHA has been shown to be converted to anti-inflammatory, proresolving and neuroprotective mediators, such as resolvins [7] and protectins
AA is converted by cyclooxygenases into 2-series prostaglandins and 4-series leukotrienes, most of which exert pro-inflammatory effects
Supplementation of DHA exerts neuroprotective effects and has been reported to afford protection from diffuse axonal injury [11] and mixed brain injury [12] as well
severe depletion of membrane DHA in the brain renders mice significantly more susceptible to TBI and impairs recovery following the injury
Omega-3 fatty acids may serve as nutraceutical agents and precondition the brain to make it more resilient to injury
it can be suggested that enriching DHA in the brain may be prophylactic and protective against brain injury
severe DHA deficiency in the brain impairs functional recovery from TBI in terms of vestibulo-motor and cognitive deficits
DHA deficiency further elevates TBI-induced production of SBDPs
less neurons were found around the injury site of DHA deficient brain after TBI compared to the omega-3 fatty acid adequate group
Linoleic acid (LA), an essential n-6 polyunsaturated fatty acid (PUFA), was identified as an agent in dietary fat that is responsible for an up-regulation of tumor growth in vivo
four amino acids (lysine, proline, alanine and arginine)
with or without conjugated linoleic acid to healthy overweight humans before and after exercising
When compared with the placebo group, several indicators, such as waist and hip circumferences, were found to have significantly decreased in the test supplement groups compared with the placebo
certain amino acids pre and post exercise help to preserve muscle mass. This has profound implications on fat loss and maintenance of fat loss long term