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Nathan Goodyear

Boswellia Serrata, A Potential Antiinflammatory Agent: An Overview - 0 views

www.ncbi.nlm.nih.gov/...PMC3309643

boswellia Frankincense inflammation NF-kappaB arthritis cancer osteoarthritis rheumatoid arthritis

shared by Nathan Goodyear on 07 Jun 16 - No Cached
  • Nathan Goodyear on 07 Jun 16
     
    review article of anti-inflammatory effects of Boswellia.  Boswellia inhibits 5-LOX and resultant leukotrienes.  3-actyl-11-keto-Beta-boswellic acid is the most potent inhibitor of 5-LOX.  As it relates to disease states and symptoms, Boswellia reduces pain in OA and RA.  Boswellia also shown to inhibit NF-kappa B: a potent nuclear transcription factor for inflammation.  In prostate cancer, Boswellia inhibits prostate tumor growth.
Nathan Goodyear

Boswellic acids: A leukotriene inhibitor also effective through topical application in ... - 0 views

www.phytomedicinejournal.com/...abstract

Boswellia Boswellia acid frankincense inflammation leukotriene 11-keto-beta-boswellic acid

shared by Nathan Goodyear on 12 Jan 14 - No Cached
  • Nathan Goodyear on 12 Jan 14
     
    Boswellic acid shown to have systemic anti-inflammatory effects through topical application.  This study only looked at Boswellia Serrata and it's triterpenes.  The different Boswellia have different levels of AKBA, BA, and BKA.
Nathan Goodyear

Modulation of arachidonic acid metabolism by ... [Carcinogenesis. 2004] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...15073046

curcumin tumeric inflammation

shared by Nathan Goodyear on 13 Sep 13 - No Cached
  • Nathan Goodyear on 13 Sep 13
     
    curcumin found to inhibit LOX and COX and thus inflammatory leukotrienes, thromboxanes, and prostaglandins.  
Nathan Goodyear

Omega-3 Fatty Acids and Inflammatory Processes - 0 views

www.ncbi.nlm.nih.gov/...PMC3257651

fats nutrition diet omega 3 inflammation NF-kappaB TNF-alpha omega-3 fish oil DHA EPA docosahexaenoic acid eicosapentaenoic acid

shared by Nathan Goodyear on 15 Sep 17 - No Cached
  • marine n-3 PUFAs have also been shown to alter the production of inflammatory proteins including chemokines, cytokines, growth factors and matrix proteases
  • Two transcription factors that are likely to play a role in inflammation are nuclear factor κ B (NFκB) and PPAR-γ
  • NFκB is the principal transcription factor involved in upregulation of inflammatory cytokine, adhesion molecule and cyclooxygenase-2 genes
  • ...3 more annotations...
  • PPAR-γ, is believed to act in an anti-inflammatory manner
  • PPAR-γ directly regulates inflammatory gene expression, it also interferes with the activation of NFκB creating an intriguing interaction between these two transcription factors
  • Both NFκB and PPAR-γ may be regulated by n-3 PUFAs.
  • Nathan Goodyear on 15 Sep 17
     
    great review of the anti-inflammatory effects of omega 3 DHA and EPA.  EPA inhibits COX and 5-LOX and their downstream prostaglandin and leukotrienes.  EPA/DHA inhibited endotoxin-stimulated IL-6, IL-8,TNF-alpha, and NFkappaB.
Nathan Goodyear

ScienceDirect.com - Prostaglandins, Leukotrienes and Medicine - Progesterone and antipr... - 0 views

www.sciencedirect.com/...0262174687900072

progesterone prostaglandin inflammation menstrual cramps dysmenorrhea

shared by Nathan Goodyear on 18 Mar 12 - No Cached
  • progesterone has been shown to inhibit PG production markedly
  • Nathan Goodyear on 18 Mar 12
     
    progesterone inhibits prostaglandin production
Nathan Goodyear

PLOS ONE: Depletion of Brain Docosahexaenoic Acid Impairs Recovery from Traumatic Brain... - 0 views

journals.plos.org/...article

DHA TBI traumatic brain injury omega 3 brain injury brain omega-3

shared by Nathan Goodyear on 31 Aug 15 - No Cached
  • The polyunsaturated fatty acids linoleic (LA, 18:2n-6) and linolenic acid (LNA, 18:3n-3) are essential fatty acids that cannot be synthesized by the body.
  • LNA serves as the precursor for long chain omega-3 fatty acids such as docosahexaenoic acid (DHA) while LA is converted into long chain omega-6 fatty acids such as arachidonic acid (AA)
  • DHA and AA are abundantly found in the brain, where these are stored mainly in membrane phospholipids
  • ...10 more annotations...
  • DHA has been shown to increase neurite outgrowth and synaptogenesis, and promotes glutamatergic neurotransmission through increase in glutamate receptor subunit expression
  • DHA has been shown to be converted to anti-inflammatory, proresolving and neuroprotective mediators, such as resolvins [7] and protectins
  • AA is converted by cyclooxygenases into 2-series prostaglandins and 4-series leukotrienes, most of which exert pro-inflammatory effects
  • Supplementation of DHA exerts neuroprotective effects and has been reported to afford protection from diffuse axonal injury [11] and mixed brain injury [12] as well
  • severe depletion of membrane DHA in the brain renders mice significantly more susceptible to TBI and impairs recovery following the injury
  • Omega-3 fatty acids may serve as nutraceutical agents and precondition the brain to make it more resilient to injury
  • it can be suggested that enriching DHA in the brain may be prophylactic and protective against brain injury
  • severe DHA deficiency in the brain impairs functional recovery from TBI in terms of vestibulo-motor and cognitive deficits
  • DHA deficiency further elevates TBI-induced production of SBDPs
  • less neurons were found around the injury site of DHA deficient brain after TBI compared to the omega-3 fatty acid adequate group
  • Nathan Goodyear on 31 Aug 15
     
    mouse study finds prolonged recovery in DHA deficient mice compared to controls.
Nathan Goodyear

Testosterone suppresses phospholipase D, causing sex differences in leukotriene biosynt... - 0 views

www.fasebj.org/...3377.full

Testosterone monocytes CVD cardiovascular disease inflammation men male hormones hormone women female 5-lipoxygenase DHT

shared by Nathan Goodyear on 14 Aug 14 - No Cached
  • Nathan Goodyear on 14 Aug 14
     
    In this study, the benefits of Testosterone was found to reduce 5-LO activity.  This has implications in CVD in men.  No evidence was found for 5alpha-DHT.
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