Leptin and Androgens in Male Obesity: Evidence for Leptin Contribution to Reduced Andro... - 0 views
press.endocrine.org/...jcem.84.10.6082
obesity leptin low T low Testosterone Testosterone low T leydig cells LH leutenizing hormone men male hormones hormone
shared by Nathan Goodyear on 04 Sep 14
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in male obesity basal and LH-stimulated androgen levels are reduced and inversely correlated with circulating leptin
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it is conceivable that in males high leptin concentrations may have a direct inhibitory effect(s) on Leydig cell function.
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testicular T de novo production is impaired in obese men and that leptin seems to be the best hormonal predictor of this blunted response to LH stimulation
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The low basal 17-OH-P levels found in massively obese men are consistent with a global impairment of Leydig cell steroidogenic function in this group of subjects.
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These findings indicate that obese men have a FM-related defect in the enzymatic conversion of 17-OH-P to T, which is revealed by hCG stimulation.
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Other studies have investigated the adrenal function in male obesity and have shown that basal cortisol and 17-OH-progesterone levels tend to decrease with the increase in the degree of obesity
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High E2 can inhibit the expression and activity of the 17,20-lyase and may be responsible for this steroidogenic lesion
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However, stimulated E2 levels were not higher in the obese than in controls, excluding the fact that the lower androgen response was due to an increased aromatization of T to E2 and that estrogens have a major role in the observed defect of 17,20-lyase activity in obese men.
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the percentage increase in the 17-OH-progesterone to T molar ratio paralleled the increase in leptin levels of obese men
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Multiple regression analysis indicated that the best hormonal predictor of the obesity-related reduction in T and FT basal levels and androgen changes after hCG stimulation was serum leptin concentration
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insulin is known to have stimulatory actions on T production that have been demonstrated in obese and normal weight men (57) and in Leydig cells in culture
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the negative correlation between insulin and basal T can be partly explained by the inhibitory action of insulin on SHBG production
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hypogonadal men have higher circulating leptin levels compared with hypogonadal patients under effective androgen substitution therapy
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The impaired androgen response to LH stimulus was due to a defect in the enzymatic conversion of 17-OH-progesterone to T, which was disclosed by a leptin-related increase in 17-OH-progesterone to T ratio