pharmacological concentrations of AA can sensitize cancer cells to chemotherapy, enhancing its antineoplastic effect
synergistic effect with conventional chemotherapeutic drugs is a fact already reported, in various types of cancer, by numerous authors, namely in pancreatic (Espey et al., 2011), prostate (Gilloteaux et al., 2014), lung (Lee et al., 2017), breast (Kurbacher et al., 1996; Wu et al., 2017) and ovarian (Ma et al., 2014) cancers.
chemosensitizing effect of vitamin C has already been proven by several authors in various types of cancer
intravenous pharmacological concentrations, may not only potentiate the effects of conventional chemotherapy, but also improve the quality of life of cancer patients
AA reinforced the anti-proliferative activity of 5-FU
Combined treatment induced a reduction of 11.5% and 43% in cell viability compared with AA or Iri therapies, respectively, emphasizing the synergistic effect
cytotoxic effect occurred with treatment with Iri alone, but also this effect was further potentiated by the presence of AA.
association of AA with Oxa showed very promising results, considering that a synergistic effect was demonstrated, in almost all conditions
AA and Oxa seem to act synergistically by the activation of the intrinsic pathway of apoptosis, translated on the statistically significant increase of the ratio between BAX and BCL-2 proteins, which in turn is associated with a decrease of Δψm