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Nathan Goodyear

Activity and expression of progesterone metabolizing 5α-reductase, 20α-hydrox... - 0 views

www.researchgate.net/...10A)_human_breast_cancer_cells

progesterone metabolites breast cancer 5-alpha-pregnanediol 4-pregnenediol

shared by Nathan Goodyear on 23 Jan 14 - No Cached
  • Nathan Goodyear on 23 Jan 14
     
    Intra mammary progesterone metabolism and its associated metabolites found to be associated with tumorigenic activity in cell lines.  This was independent from ER PR status.  5 alpha-pregnanes were found to be pro-tumor and 4-pregnanes were anti-tumor.
Nathan Goodyear

http://erc.endocrinology-journals.org/content/18/5/R175.full.pdf - 0 views

erc.endocrinology-journals.org/...R175.full.pdf

DHT metabolite metabolites 3-alpha androstanediol 3-beta androstanediol prostate cancer male hormone hormones men

shared by Nathan Goodyear on 27 Jan 14 - No Cached
  • Nathan Goodyear on 27 Jan 14
     
    Good review of intra-tumor androgen synthesis from DHT metabolites.
Nathan Goodyear

[Antitumor effect in mice of an organic germanium compound (Ge-132) when different admi... - 0 views

www.ncbi.nlm.nih.gov/...4073929

germanium NK cells immune system cancer

shared by Nathan Goodyear on 30 May 18 - No Cached
  • Nathan Goodyear on 30 May 18
     
    IV germanium augments NK activity in mouse blood providing anti-tumor activity.  Different activity found with po and intra-peritoneal injection--augmentation of cytotoxic macrophages.  Prolongation of life was not found in the IV arm.
Nathan Goodyear

Intratumoral T Cells, Recurrence, and Survival in Epithelial Ovarian Cancer | NEJM - 0 views

www.nejm.org/...NEJMoa020177

T cells cancer

shared by Nathan Goodyear on 25 May 21 - No Cached
  • Nathan Goodyear on 25 May 21
     
    Intra-tumoral CD3+ T cells correlates with positive outcomes.
Nathan Goodyear

Starting the fight in the tumor: expert recommendations for the development of human in... - 0 views

www.ncbi.nlm.nih.gov/...PMC6290929

intra lesional injection cancer intratumoral injection intratumoral intratumoral protocol intra-tumoral injection

shared by Nathan Goodyear on 26 Dec 23 - No Cached
  • Nathan Goodyear on 26 Dec 23
     
    To guide protocol creation, i.e. needle sizes, injections…
Nathan Goodyear

Low-Dose Chemotherapy with Insulin (Insulin Potentiation Therapy) in Combination with H... - 0 views

www.ncbi.nlm.nih.gov/...PMC3357525

prostate cancer IPTLD low-dose chemotherapy cancer chemotherapy insulin potentiation therapy LDMC low-dose metronomic chemotherapy IPT

shared by Nathan Goodyear on 25 Jan 18 - No Cached
  • The method of insulin potentiation therapy was empirically invented in 1930 from Mexican doctor D. Perez Garsia
  • increases the permeability of cell membrane
  • influences the metabolic processes in human body with the increase of the regenerating processes
  • ...9 more annotations...
  • facilitates the transport of intra and extra cellular liquids which helps the organism to eliminate the toxic products
  • The increased number of insulin receptors on the tumor cell, in comparison to the normal one, allows the before mentioned 2 factors to act predominantly
  • Increased permeability after the insulin effect on the cellular membrane results in increased intracellular quantity of antitumor agents
  • have other endocrine effects: directly stimulates suprarenal gland to produce epinephrine and glucocorticoid hormones and stimulates ACTH secretion. These endocrine effects also have a positive influence on the regenerating processes
  • Insulin influences the intracellular metabolism of the tumor cell, which leads to increase of the number of cells in phase S, where they are with highly sensitive to specific chemotherapeutics.
  • After the first 6 IPT applications overall (groups A and B) response to treatment on PSA criteria shows partial effect and stabilization in 12 of 16 (75%) patients
  • After the 10th IPTLD application or 3 months after starting treatment, complete response, partial response, and stabilization were observed in 4 of 9 (66.6%), while in 3 of 9 (33.3%) was registered complete effect
  • the advanced stage of disease in patients treated
  • Quality of life after the second IPTLD application is significantly improved
  • Nathan Goodyear on 25 Jan 18
     
    IPT found to be effextive in treated castrate-resistant prostate cancer.
Nathan Goodyear

Use and Safety of Intratumoral Application of European Mistletoe (Viscum albu... - 0 views

journals.sagepub.com/...1534735414563977

mistletoe cancer intra-tumoral injection

shared by Nathan Goodyear on 21 Apr 20 - No Cached
  • Nathan Goodyear on 21 Apr 20
     
    To be read
Nathan Goodyear

Intratumoral Mistletoe (Viscum album L) Therapy in Patients With Unresectable... - 0 views

journals.sagepub.com/...1534735413513637

pancreatic cancer intra-tumoral injection mistletoe

shared by Nathan Goodyear on 21 Apr 20 - No Cached
  • Nathan Goodyear on 21 Apr 20
     
    To be read
Nathan Goodyear

Intralesional and subcutaneous application of Viscum album L... : Medicine - 0 views

journals.lww.com/...articleviewer.aspx

intra-tumoral injection cancer Mistletoe cervical cancer

shared by Nathan Goodyear on 21 Apr 20 - No Cached
  • Nathan Goodyear on 21 Apr 20
     
    To be read
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