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Nathan Goodyear

The SARS-CoV-2 Spike Protein Activates the Epidermal Growth Factor Receptor-Mediated Si... - 0 views

  • we wanted to investigate if other molecular targets and pathways may be used by SARS-CoV-2. We investigated the possibility of the spike 1 S protein and its receptor-binding domain (RBD) to target the epidermal growth factor receptor (EGFR) and its downstream signaling pathway in vitro using the lung cancer cell line (A549 cells). Protein expression and phosphorylation were examined upon cell treatment with the recombinant full spike 1 S protein or RBD. We demonstrate for the first time the activation of EGFR by the Spike 1 protein associated with the phosphorylation of the canonical Extracellular signal-regulated kinase1/2 (ERK1/2) and AKT kinases and an increase in survivin expression controlling the survival pathway.
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    WTF!!
Nathan Goodyear

The role of opioids in cancer response to immunotherapy | Journal of Translational Medi... - 0 views

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    opioids use during immunotherapy is associated with early progression, potentially representing a predictive factor for PFS and negatively influencing OS as well.
finchloe121

5 Things You Need To Understand If You are Having Chronic Pain! - 0 views

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    Chronic pain is a type of pain that usually lasts for weeks to months. This pain can come and go, and it can be anywhere in the body. Chronic pain can lead to anxiety, depression, and insomnia. Chronic pain is quite different from acute pain and there are some differences between the two types. People usually experience severe pain, when it is injured by a broken bone or a cut on the skin. This pain does not last long. Pain is not something that can be ignored. If it grows, it should be fixed. As fear and pain persist, one begins to think negatively. Long-term negative thoughts begin to form in his mind, a process called fear conditioning. This factor causes an increase in blood pressure and anxiety disorders. Chronic pain is difficult to treat, and results in increased pain, fear, and negative thoughts. Extreme levels of fear lead to more pain, and the cycle of pain threats can be difficult to break. One of the best pills used to treat body pain symptoms is Hydrocodone 325mg, which you can easily buy from any trusted online pharmacy, such as Pharma Health Online.
indiacardiacsurg

Defeat Heart Diseases In Little Ones With Affordable Cost Pediatric Cardiac Surgery In ... - 0 views

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    Many factors influence the decision to seek pediatric cardiac surgery in India. Some people travel for affordable cost pediatric cardiac surgery in India because it is much cheaper compared to other countries. Nonetheless, others can also travel to receive a procedure or therapy not available in the home country as pediatric surgical procedure success rates in India are comparably very high.
Nathan Goodyear

Prooxidative inhibition against NF-κB-mediated inflammation by pharmacologica... - 0 views

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    The title tells it all.
indiacardiacsurg

Lifetime Monitoring After Pediatric Heart Surgery In India May Reduce Adult Hypertensio... - 0 views

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    Other factors raising the risk of future hypertension were CHD repair surgery at age 3 months or younger, needing kidney dialysis during recovery from the low cost of pediatric cardiac surgery in India, and one or more cardiac surgeries after the initial repair.
spineneuro

Robotic Healing: Making Sense of Spine Surgery Expenses in India ~ Neuro and Spine Surg... - 0 views

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    Cost is a significant factor driving foreign patients to choose robotic spine surgery in India, as the cost difference is approximately 55-85% less than in developed countries like the US and the UK.
spineneuro

Back to Wellness: Why Mozambique Patients Opt for Spinal Fusion Surgery in India - 0 views

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    The cost factor plays a pivotal role in attracting Mozambique patients to opt for spinal fusion surgery, as the expenses are approximately 55-85% lower than those in developed nations such as the US and the UK.
spineneuro

Cutting-Edge Care: Unveiling the Price Tag of Robotic Spine Surgery in India - 0 views

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    The cost of robotic spine surgery India is notably affordable, remaining a fraction of the expenses incurred in other nations. Even when factoring in accommodation and boarding costs, the cost of robotic spine surgery India remains the lowest globally. The country is renowned for providing exceptionally competitive cost of robotic spine surgery India at some of the most prestigious medical establishments.
spineneuro

Spine And Neuro Surgery Hospital India: Tech-Driven Healing: Robotic Spine Surgery Prom... - 0 views

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    Additionally, patients achieve successful outcomes with significant savings, around 70%, even when factoring in travel and related expenses. A comparison of the cost of robotic spine surgery in India and several Western countries indicates that India offers a highly economical option.
pharmacybiz

MHRA Approves Life-Saving Zolbetuximab for Gastric & Gastro-Oesophageal Cancer - New Ho... - 0 views

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    A new cancer treatment for adults with stomach (gastric) and gastro oesophageal junction cancer has been approved by the Medicines and Healthcare products Regulatory Agency (MHRA) this week. According to the MHRA, Zolbetuximab, a monoclonal antibody, is designed to target and destroy specific cancer cells, offering a new option for patients whose cancer is inoperable or has spread. The new targeted cancer treatment for gastric and gastro-oesophageal junction cancer is administered intravenously in combination with standard chemotherapy regimens and is typically given every two to three weeks under the supervision of an experienced oncologist. Zolbetuximab is indicated for patients whose tumors are positive for the Claudin18.2 (CLDN18.2) protein and negative for the Human epidermal growth factor receptor 2 (HER2) protein.
Nathan Goodyear

Hypogonadism as a risk factor for cardiovascular mortality in men: a meta-analytic study - 0 views

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    meta-analysis finds that low T associated with increased cardiovascular mortality in men.  Additionally, higher Estradiol is associated with increased CVD and CV mortality
Nathan Goodyear

Molecular Control of Immune/Inflammatory Responses: Interactions Between Nucl... - 0 views

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    Benefits of progesterone, are in part, due to its function on the immune system.  Progesterone shown to decrease T cell activity, macrophage activity and NK cell activity.  Aside, NK cell activity has been found to be increased in those with recurrent first trimester miscarriages and progesterone defects.  So, low progesterone allows for a rise in NK cell activity and inflammation that is detrimental to a developing pregnancy.  If that is the case in pregnancy, what about the rest of the body?
Nathan Goodyear

Ovarian hormones and reproductive risk factors for breast cancer in premenopausal women... - 0 views

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    this study looked at ovarian sex hormones as it relates to premenopausal women and breast cancer risk.  They used saliva as the test medium to evaluate estradiol and progesterone.
Nathan Goodyear

Tumor necrosis factor-α and muscle wasting: a cellular perspective - 0 views

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    TNF-alpha associated with muscle loss and weakness.  TNF-alpha may also decrease testosterone production/secretion resulting in muscle loss.  
Nathan Goodyear

Hypogonadism as a risk factor for cardiovascular mortality in men: a meta-analytic study - 0 views

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    Good article. Discusses the association between low Testosterone and cardiovascular risk in men. The conclude that no direct cause effect relationship has been provided, but a clear association is seen. Numerous studies have shown this association.
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