Article discusses the immunoexcitotoxic process involved in chronic TBI. This is likely to be the underlying process involved in NFL and other football players delayed neurological effects. A similar process has been see in combat veterans returning from the theatre.
Estriol found to be beneficial in experimental model of MS called EAE. The effect would be through E3's preferential binding to ERbeta. This study finds benefit in men and women.
The freely diffusible plasma fraction is distributed extensively
throughout tissues, reaching highest concentrations in bone, teeth, liver,
lungs, kidneys, brain and spleen
Inorganic lead does not
undergo any metabolic transformation or digestion in the intestines, or
detoxification in the liver.5
With chronic exposure over a long period of time, most absorbed lead
ends up in bone
The total bodily content of lead is called the
body burden; in a steady state, about 90 percent of the body burden is bound to
bone.2
n general, lead is excreted quite slowly from the
body (with the biologic half-life estimated at 10 years). Since excretion is
slow, accumulation in the body occurs easily.2
hronic toxicity is an
insidious illness with protean manifestations.3,6 Symptoms may include arthralgias, headache,
weakness, depression, loss of libido, impotence and vague gastrointestinal
difficulties.
Late effects may include chronic renal failure, hypertension,
gout and chronic encephalopathy.6