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umar111

Yves Saint Laurent perfume - 0 views

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    Yves Saint Laurent is a brand that has become synonymous with luxury, sophistication, and style. Founded by Yves Saint Laurent himself in 1961, the brand has established a reputation for producing some of the most iconic fashion designs and beauty products of all time. One of the most popular products in the Yves Saint Laurent beauty line is their perfume collection. From their classic fragrances to their newer additions, Yves Saint Laurent perfumes are a staple in any fragrance collection.
umair222

Best Perfumes in Pakistan | Men Fashion | Men Perfumes | Perfume Collection | Top 5 #be... - 0 views

shared by umair222 on 30 Mar 23 - No Cached
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    Sauvage Eau de Parfum: "Discover the intense and captivating scent of Sauvage Eau de Parfum by Dior. This fragrance for men features a blend of powerful and sophisticated notes, including bergamot, Sichuan pepper, lavender, and vanilla. With its long-lasting scent and masculine character, Sauvage Eau de Parfum is the perfect choice for any occasion." Order Now https://plazza.pk/product/sauvage-dio... Tom Ford London Perfume: "Experience the luxurious and sophisticated scent of Tom Ford London perfume. This unisex fragrance features notes of oud wood, patchouli, and incense, creating a warm and inviting aroma that is perfect for the cooler months. With its elegant and refined character, Tom Ford London is the perfect addition to any fragrance collection." Order Now https://plazza.pk/product/tom-ford-lo... Versace Dylan Blue Perfume: "Indulge in the seductive and captivating scent of Versace Dylan Blue perfume. This fragrance for men features notes of grapefruit, fig leaves, and violet, creating a fresh and vibrant aroma that is perfect for everyday wear. With its masculine and modern character, Versace Dylan Blue is the perfect choice for the confident and stylish man." Order Now https://plazza.pk/product/versace-dyl... Versace Eros Flame Perfume: "Experience the intense and passionate scent of Versace Eros Flame perfume. This fragrance for men features notes of black pepper, orange blossom, and tonka bean, creating a bold and powerful aroma that is perfect for the evening. With its warm and sensual character, Versace Eros Flame is the perfect choice for the modern and confident man." Order Now https://plazza.pk/product/versace-ero... Dolce & Gabbana The Only One: "Discover the unique and alluring scent of Dolce & Gabbana The Only One perfume. This fragrance for women features notes of bergamot, violet, and coffee, creating a warm and sensual aroma that is perfect for any occasion. With its feminine and sophisticated character, Dolce & Gabbana The Only One is the
Nathan Goodyear

Toll-like receptor signaling links dietary fatty acids to the metabolic syndrome - 0 views

  • Activation of the innate immune system controls macronutrient metabolism
  • the innate immune response is the first line of defense against invading pathogens, wherein highly conserved pathogen-associated molecular patterns (PAMPs) are recognized by cognate pattern recognition receptors (PRRs
  • many studies have supported the idea that cytokine signaling directly promotes insulin resistance
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  • innate immune system may be causally linked to obesity
  • adipose tissue contains a substantial population of macrophages, and macrophage-driven adipose inflammation contributes significantly to the pathogenesis of obesity
  • Collectively, activation of the innate immune system is strongly associated with ASCVD, insulin resistance, and obesity, and recent evidence suggests that much of this association can be traced to a unique family of PRRs known as TLRs
  • TLRs are a family of type I transmembrane receptors, currently thought to comprise at least 13 members in mammals, that specifically recognize a variety of microbial PAMPs and trigger host cellular responses
  • Free SFAs have indeed been demonstrated to elicit TLR4-dependent and TLR2-dependent responses in several cell types.
  • Endogenous SFAs released from adipocytes activate cocultured macrophages via TLR4 [18], indicating the potential for cellular crosstalk in adipose tissue. Collectively, there is a growing body of evidence that SFAs promote, whereas long chain PUFA antagonize, TLR4-dependent and TLR2-dependent signaling in multiple cell models
  • In an elegant study, Shi et al. [16] demonstrated that SFAs activate TLR4-dependent signaling in both macrophages and adipocytes, and mice lacking TLR4 are protected against insulin resistance driven by intravenous lipid infusion
  • In addition to effects in macrophages and adipocytes, SFAs can activate TLR4 in the hypothalamus, which triggers a central inflammatory response that results in resistance to anorexigenic signals
  • endogenous SFAs can indeed promote innate immunity and inflammatory disease
  • This finding strongly supports the work of Hwang and coworkers [19–22] demonstrating that ω-3 PUFAs can effectively counteract SFA-induced TLR4 activation in cultured macrophages and dendritic cells.
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    high dietary fatty acids linked to metabolic syndrome through TLR.
Nathan Goodyear

Steroids in Saliva for Assessing Endocrine Function - 0 views

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    Another study validates saliva as a reliable method for hormone testing.  The author concludes: "steroid concentrations in saliva are independent of flow rate and reflect those in the free fraction in plasma".  This study also discuss potential collection problems and means to resolve them.
toxlab

Tox lab billing and collections - 2 views

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    To ease off the process of tox lab billing and collections, Nath has rolled out software which is a perfect blend of multiple processes, contemporary technology and the manpower involved. Check out today and incorporate it into your system effortlessly!
Nathan Goodyear

Is late-night salivary cortisol a better screening... [N Z Med J. 2012] - PubMed - NCBI - 0 views

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    this study of 40 obese patients found saliva cortisol testing less specific than urinary; but more than Dexamethasone suppression test.  The problem with this is several fold: first, this is done via ELIZA and not Mass Spec and second, 24 hour urine collection is hard to achieve in real life.
Nathan Goodyear

Diagnostic Potential of Saliva: Current State and Future Applications - 0 views

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    saliva testing is the new "gold standard" for hormone evaluation.  No testing method is perfect and thus there are guidelines for salivary collections.  However, saliva is equal too or superior to blood for hormone evaluation.
Nathan Goodyear

Diagnosis of secondary adrenal insufficiency in patients with hypothalamic-pituitary di... - 0 views

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    European journal of endocrinology article compared serum to salivary cortisol and found them to be equal, but due to ease of collection, salivary cortisol to be preferable.  This article was using cortisol to assess HPA axis dysfunction.
Nathan Goodyear

Validation of a cortisol enzyme immunoassay and characterization of salivary cortisol c... - 0 views

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    granted, this comes from the American Journal of Primatology; but their conclusion says it all: "we recommend that saliva collection may be the moste effective method of measuring stress reactivity and as the potential to complement behavioral, cognitive, physiologic, and welfare studies".
Nathan Goodyear

Saliva collection devices affect sex steroid ... [Clin Chim Acta. 2012] - PubMed - NCBI - 0 views

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    This study suggests that "salivette" devices alter saliva hormone concentrations.  Salivette's are usually cotton rolls in saliva tubes.  At Seasons, we do not use the Salivette rolls.
Nathan Goodyear

Hormonal Modulation in Aging Patients with Erectile Dysfunction and Metabolic Syndrome - 0 views

  • Hypogonadism and MetS are strongly associated [12, 13, 16], having even been demonstrated that with the increasing number of MetS parameters there is a proportional raise in the incidence of hypogonadism
  • increasing number of MetS components is inversely associated with T levels
  • the presence of MetS did not prove to be a significant determinant of hypogonadism, as it did not lead to a decline in T levels, in MetS patients with already established hypogonadism, the increasing number of MetS features was associated with further decline in T
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  • In the setting of MetS, hypertriglyceridemia and increased WC have been reported as the most important determinants of hypogonadism
  • recent literature consistently associates obesity not only with higher risk of hypogonadism [4, 6, 27] but also with lower T levels
  • Visceral adiposity has been particularly related with reduction of T and SHBG levels (independent of other metabolic disorders)
  • WC was one of the MetS parameters with the greatest influence in T levels decrease, presenting itself as a strong risk factor for hypogonadism development
  • MetS-related T decline was not accompanied by an increase in pituitary LH levels, suggesting impairment in gonadotropin secretion
  • The molecules behind this smoothing compensatory effect of GnRH/LH are still unknown, but estrogens and insulin, as well as leptin, TNF-α, and other adipokines, were proposed candidates
  • fat stores undertake an increase aromatization of androgens, therefore raising estrogen levels [9, 15], which in turn decrease LH secretion
  • our data contradicts the concept that estradiol exerts a negative feedback on hypothalamic GnRH secretion
  • taking into account that high estradiol levels have already been described as the only abnormality in a subset of patients with ED, the hypothesis that the later might not only be caused by androgen deficiency is becoming increasingly evident
  • it has been reported that the chronic exposure to phosphodiesterase type 5 inhibitors (PDE5i), widely used for the treatment of ED, may influence serum estradiol levels
  • thyroid disorders (specially hyperthyroidism) have been related to ED and hypogonadism, and so must be considered in a sexual-dysfunction setting
  • It is clear from the current literature that collecting a more thorough hormonal panel might be a wise approach to further uncover hormonal relations
    • Nathan Goodyear
       
      outstanding point.  This hits to the point that Low T is the effect not the cause.
  • We concluded that in ED patients with hypogonadism and MetS, the attenuated response of HPG axis (normal or low LH levels) might not always be due to an underlying adiposity-dependent estrogen-raising effect.
  • our findings indicate that ED, aging, and estradiol might have a stronger connection than what is currently described in the literature.
  • this study underlines the importance of the collection of a full hormonal panel in ED men
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    low T strongly associated with metabolic syndrome in men.
Nathan Goodyear

Adverse Events Associated With Testosterone Replacement in Middle-Aged and Older Men: A... - 0 views

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    meta-analysis if 19 studies finds no increase in cardiovascular events with Testosterone therapy.  The authors did find a collective increase in prostate events, however when these were itemized individually there was not increase.
Nathan Goodyear

The Importance of Vitamin D for Your Health - 0 views

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    Great collection of studies on vitamin D.
Nathan Goodyear

Adequacy of saliva 17-hydroxyprogesterone determin... [Steroids. 2006] - PubMed result - 0 views

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    Adequacy of saliva progesterone determination using various collection methods.
Nathan Goodyear

A Bibliography of Scientific Literature on Fluoride - 0 views

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    exhaustive literature collection on the dangers of flouride
Nathan Goodyear

Environmental Estrogen Exposure During Fetal Life: A Time Bomb for Prostate Cancer: End... - 0 views

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    environmental toxins that have estrogenic activity, i.e. BPA alter the prostate stem cells.  These and other xenoestrogens, as they are collectively called, increase the sensitivity of the prostate to estrogen.  This increases the risk of prostate Ca.  This just sets the pattern of signal interpretation and sensitivity.  Add in the continued estrogenic environment, add in the excess weight, the increased aromatase activity and resultant estrogen production and one has all the ingredients for prostate cancer.
olivehealthcare

Blood Test at Home - 0 views

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    We offer the full range of blood test at home with results available as early as 48 hours. Mobile Phlebotomy offered for blood sample collection.
olivehealthcare

Blood Tests | Blood Test at Home | Mobile Phlebotomy - 0 views

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    We offers the full range of blood tests with results available as early as 48 hours. Home-visits (mobile phlebotomy) offered for blood sample collection for both NHS and Private blood tests. Pregnancy HCG, Hepatitis B Immunity, Tuberculosis, Occupational Health, Vitamin tests, Glucose, Cholesterol, etc.
KELLY147

The Role of Artificial Intelligence in the Logistics Industry - 0 views

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    The AI plays a crucial role in saving time, decreasing costs, and improving productivity with cognitive industrialization. It helps automate many time-consuming processes and assists in market forecasting. AI positively transforms warehousing operations to collect and interpret information or inventory processing.
snfilms

Music Album Of Clean Bandit - 0 views

shared by snfilms on 09 May 21 - No Cached
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    Check out #CleanBandit Superhit #musicvideos collection on #sdtunes http://www.sdtunes.com/.../clean-bandit-huge-hit-music...
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