Group items tagged

NEJM reanalyzed the results from 12 antidepressant studies involving over 12,000 patients and found that 40% of studies that found no benefit for antidepressants were omitted.  This seriously altered the statistics and is obvious manipulation of data.  This brings the current recommendations on antidepressants into serious question.

cochrane review of 9 studies involving 751 patients, shows little difference between antidepressants and "active placebos".  The two groups both improved mood, but there was very little difference between the 2.  Take home: "...the effects of antidepressants my be generally overestimated..."

antidepressants linked to increased arterial thickness; We must think about the body from a dynamic perspective, not a linear one

Sudden cardiac death secondary to antidepressant and antipsychotic drugs

antidepressants do more harm than good, is the conclusion of this study.

Interesting finding in this study. They looked at Total Testosterone and bioavailable Testosterone and found that antidepressant therapy increased both values post treatment.  This is counter to what has been readably seen in men--with a decline.  The abstract here does not point disclose the actual Testosterone numbers.  I wonder if the well known disruption of the CYP enzymes by antidepressants slowed clearance and increased Testosterone levels.  This study did not look at other hormones or inflammatory cytokines.  Very tunneled vision study.  Nothing can be drawn from this study.

antidepressants correlated with metabolic syndrome

antidepressants shown to reduce heart rate variability (HRV) and an increased heart rate (HR), both of which increase cardiovascular disease (CVD).

S-adenosyl-l-methionine (SAMe) as antidepressant: meta-analysis of clinical studies.

serotonin transporters, SERT, major depression and antidepressant treatment

antidepressants increase sudden cardiac death and are marker for worse depression

PPI therapies, histamine (specifically type II) antagonists and antidepressants are associated with clostridium difficile infection. 

study reveals that antidepressants no better than placebo. This study was sponsored by the National Institute of Mental Health.  

SSRI as well as other antidepressants cause hyperprolactinemia.  Antipsychotics are well known to increase prolactin production.

Prozac disrupts mitochondrial function, which  leads to cell death.

Antidepressants shown to increase Breast and Ovarian Cancer risk in review of 61 articles. Clear relationship found, but exact risk still needs further research.  Interestingly, the pharmaceutical industry's research, showed no risk.

anti-depressants inhibit inflammatory IL-6 production from microglial cells in brain, suggesting anti-inflammatory effects of antidepressants as role in improving depression symptoms

This is a reference to a blog, but a well referenced blog on low libido and meds, particularly antidepressants and psychotropics.

analysis of 3 clinical trials found that up to 40% of 447 women that were treated with antidepressant therapy found no benefit.  Physical symptoms were provided little, if any benefit.