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Mitochondrial-nuclear epistasis: Implications for human aging and longevity.

antioxidants protect mitochondria oxidative stress and slow aging

mitochondria and aging

Must read on the free radical theory of aging to application of disease prevention as it relates to neurodegenerative disease

Great discussion on the free-radical theory of aging and the effects of mitochondria

Aged garlic reduces oxidative stress in smokers and non-smokers

middle-aged obesity and dementia

Study finds age and BMI associated decline in serum Testosterone levels in Finnish men.  This decline was worsened in more recently born age groups evaluated.

Tynor Knee Cap Pair Knee Caps are tubular supports widely used in orthopaedic practice to provide mild compression warmth & support to the limbs and joints, to allay pain and inflammation, generally associated with old age, arthritis, sports injury etc. Hypoallergenic Four way stretch Uniform compression Simple pull on application Tynor Knee Cap (Pair) Features Bilayered , cotton on the inside Dermophillic interpahse with the skin Better sweat absorption Better comfort Better patient compliance. No allergies or rash Bilayered, nylon on the outside Ensures long life Excellent aesthetics Color fastness. Two layers enclose air space retains body heat effectively Provides therapeutic warmth and assuring support to the knee. Four-way stretchable seamless tubular fabric Effective compression Enhanced comfort. No vaso constriction. Adjusts compression even on uneven diameters

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good article discussing the positive impact of IGF-1 on atherosclerosis.  This hormone, under the control of HGH, is important in the healing and regenerative process.  Thus, the use of the term "anti-aging".  However, these two hormones simply help the body heal, repair, and regenerate itself.  Not surprising, inflammation (TNF-alpha) counteracts these positive effects.

good discussion article on testosterone and the effects of age.  

This study found that in longitudinal studies, testosterone decline accelerated compared to cross sectional studies.  They concluded that decreasing health could be the explanation.  But, what if the decline in testosterone explained the decreasing health?

DHEAS declines with aging.

Estrogen and the aging brain of a women.  Good review of the science of how estrogen effects the neurological system of the woman.

Overexpression of T3 receptors can contribute to muscle loss with aging.  

epidemiological study finds that telomere length inversely correlated with longevity, especially in those > 75.  The sex differences was significant beyond the age of 50, with women having longer telomere lengths.

DHEA declines with age.  DHEA therapy, 50 mg daily, was found to reduce TNF-alpha and IL-6.  DHEA also lowered triglycerides.

waist to height ratio reliable predictor of low T in men.

biological age determined by methylation.