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Nathan Goodyear

A randomized study of immunotherapy with low-dose subcutaneous interleukin-2 plus melat... - 1 views

www.ncbi.nlm.nih.gov/...7900237

IL-2 melatonin immunotherapy immune system cancer lung cancer chemotherapy

shared by Nathan Goodyear on 01 Jun 18 - No Cached
  • Nathan Goodyear on 01 Jun 18
     
    Average progression-free time and percentage of patients alive at 1 year was significantly higher in those using IL-2 and melatonin compared to chemotherapy in aggressive NSCLC. Of note, in this study, they used a repeat cycle of IL-2 and MLT as well as a once/week maintenance IL-2 and MLT.
Nathan Goodyear

Epithelial‐to‐mesenchymal transition (EMT) to sarcoma in recurrent lung adeno... - 0 views

www.ncbi.nlm.nih.gov/...PMC6718027

chemotherapy EMT epithelial to mesenchymal transition

shared by Nathan Goodyear on 19 Apr 20 - No Cached
  • facilitates the dissemination of cancer cells to distant organs. In addition to facilitating metastasis, EMT is thought to generate cancer stem cells (CSCs), which are generally resistant to apoptosis and to standard chemotherapeutic drugs and radiotherapy
  • IL‐6, which enhances TGF‐β‐induced EMT changes in NSCLC
  • aside from TGF‐β and Snail, several other signalling pathways including Notch, Wnt, and integrin are known to activate EMT through transcriptional repression of E‐cadherin
  • ...4 more annotations...
  • increasing evidence that treatment with chemotherapy or chemoradiotherapy can induce EMT in NSCLC which in turn is thought to generate CSCs which are generally resistant to such treatments
  • cisplatin has been shown to increase the release of Interleukin‐6 (IL‐6) and expression of transforming growth factor beta (TGF‐β)
  • EMT confers an invasive phenotype and
  • IL‐6 serves to block apoptosis in cells
  • Nathan Goodyear on 19 Apr 20
     
    Chemotherapy causes EMT.
Nathan Goodyear

O2⋅− and H2O2-Mediated Disruption of Fe Metabolism Causes the Differential Su... - 0 views

www.cell.com/...S1535-6108(17)30062-4

IV vitamin C cancer vitamin C alternative medicine

shared by Nathan Goodyear on 12 Apr 17 - No Cached
  • Nathan Goodyear on 12 Apr 17
     
    IV vitamin C shown to have selective cytotoxicity, no surprise, on lung cancer and glioblastoma cells via H2O2, while at the same time safe to other cells.  
Nathan Goodyear

O2*− and H2O2-Mediated Disruption of Fe Metabolism Causes the Differential Su... - 0 views

www.ncbi.nlm.nih.gov/...PMC5497844

Cancer "vitamin C" "IV vitamin H2O2 Fe ascorbate ascorbic acid redox

shared by Nathan Goodyear on 04 Dec 18 - No Cached
  • Nathan Goodyear on 04 Dec 18
     
    Great read and synopsis of the interaction between vitamin C and the altered redox balance in cancer cells. The process involves Fe in part. Ascorbate increases H2O2 which increases the label Fe pool.
Nathan Goodyear

[Artesunate combined with vinorelbine plus cisplatin in treatment of advanced non-small... - 0 views

www.ncbi.nlm.nih.gov/...18241646

Artesunate cancer NSCLC "non-small cell lung cancer"

shared by Nathan Goodyear on 11 Dec 18 - No Cached
  • Nathan Goodyear on 11 Dec 18
     
    Artesunate augments cisplatin and navelbine.
Nathan Goodyear

Update on Programmed Death-1 and Programmed Death-Ligand 1 Inhibition in the Treatment ... - 0 views

www.ncbi.nlm.nih.gov/...PMC5382272

cancer PD-1 immunotherapy programmed death-1

shared by Nathan Goodyear on 20 Apr 18 - No Cached
  • Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), the first immune checkpoint receptor to be clinically targeted, is exclusively expressed on the surface of CD4+ and CD8+ T cells in lymphatic tissue and is involved in T-cell regulation, proliferation, and tolerance
  • programmed death-1 (PD-1) immune checkpoint inhibitor antibodies, which restores T-cell effector function and augments the host anti-tumor response by blocking the binding of either programmed death-ligand 1 (PD-L1) and/or PD-L2 to PD-1 receptors
  • lung cancer is the first and second cause of cancer mortality in men and women
  • ...1 more annotation...
  • Eighty-five percent of lung cancers are non-small-cell lung cancer (NSCLC)
  • Nathan Goodyear on 20 Apr 18
     
    To read update article on PD-1 and immunotherapy.
Nathan Goodyear

30-day mortality after systemic anticancer treatment for breast and lung cancer in Engl... - 0 views

www.thelancet.com/...fulltext

chemotherapy cancer mortality

shared by Nathan Goodyear on 11 Jul 17 - No Cached
  • Our data also suggest that 30-day mortality might be higher than previously estimated by several clinical trials.9, 10 The 30-day mortality rate after SACT with curative intent for NSCLC reported here is high at 3% compared with published trial data for the standard treatments, which suggested that 0·8% of patients died from treatment-induced toxicity when chemotherapy was given as adjuvant treatment alongside surgery
  • findings of clinical trials in selected age cohorts cannot readily be generalised to all patients
  • Nathan Goodyear on 11 Jul 17
     
    Population study from England finds significant increase in mortality in first 30 days of chemotherapy in breast and lung cancer treatment.  The previously published trial dat was 0.8%; this study was as high as 3%.  This cast doubt as to the inference of the risk from clinical trials to the general population.
Nathan Goodyear

Thymosin alpha-1 blocks the accumulation of myeloid suppressor cells in NSCLC by inhibi... - 0 views

pubmed.ncbi.nlm.nih.gov/32942159

MDSC TME TA-1 VEGF tumor microenvironment myeloid-derived suppressor cells thymosin alpha-1

shared by Nathan Goodyear on 16 Aug 21 - No Cached
  • Nathan Goodyear on 16 Aug 21
     
    TA-1 alters tumor microenvironment via VEGF induced decrease in MDSC.
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