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Nathan Goodyear

Testosterone and metabolic syndrome Cunningham GR - Asian J Androl - 0 views

www.ajandrology.com/article.asp

Testosterone metabolic syndrome MetS TT total Testosterone SHBG men male hormone hormones Estradiol insulin resistance

shared by Nathan Goodyear on 02 Mar 15 - No Cached
  • The relationship of low testosterone to MetS often is considered to be bidirectional; however, the relationships probably are not direct
  • Many of the components of the MetS are recognized risk factors for the development of cardiovascular disease (CVD)
  • Multiple cross-sectional studies have found low TT and low sex hormone binding globulin (SHBG) levels in Caucasian and African-American men with the MetS, irrespective of age
  • ...20 more annotations...
  • Low TT and SHBG levels also are prevalent in Chinese [7],[8] and Korean [9] men with the MetS
  • Normally 40%-50% of TT is bound to SHBG, so reducing SHBG levels will decrease TT.
  • Hyperinsulinism suppresses SHBG synthesis and secretion by the liver
  • significant increase in SHBG levels occurred after acutely lowering insulin levels in obese men
  • Estradiol levels are increased in men with the MetS, and they are positively correlated with the number of abnormal components of the MetS.
  • Although it is known that estrogen will increase SHBG levels, apparently the hyperinsulinism associated with obesity has a greater effect on SHBG levels
  • Estradiol also can inhibit luteinizing hormone (LH) secretion
  • Inflammatory cytokines are thought to have a direct effect on the pituitary to reduce LH secretion [15] and also a direct effect on Leydig cell secretion of testosterone
  • Low TT Levels have been shown to predict development of the MetS in men with normal BMI
  • Men in the lowest quartiles of serum TT, calculated free testosterone (cFT) and SHBG at baseline had the highest odds ratios for developing the MetS or DM during the 11 years follow-up
  • More recently, investigators conducting population-based studies have reported that only SHBG is associated with future development of the MetS
  • Additional evidence that low TT increases the risk of MetS comes from androgen deprivation treatment of prostate cancer
  • Low TT and low bioavailable testosterone (bT) were each significantly associated with elevated 20 years risk of CVD mortality in an older population in which cause-specific mortality was age, adiposity, and lifestyle-adjusted.
  • combination of low bT and ATP III-defined MetS is associated with increased cardiovascular mortality in men aged 40 years and above
  • in elderly men, testosterone may weakly protect against CVD. Alternatively, low TT may indicate poor general health
  • Muraleedharan and Jones [27] concluded that there is convincing evidence that low T is a biomarker for disease severity and mortality.
  • The evidence that TRT improves insulin sensitivity and glucose control is conflicted
  • It is widely recognized that testosterone treatment can reduce fat mass and increase lean body mass; however, until recently most reports have not been associated with much weight loss
  • Changes in body composition and weight loss are considered potential mechanisms by which testosterone treatment improves insulin sensitivity and glucose control in patients with diabetes. Effects on inflammatory cytokines [38] and changes in oxidative metabolism [39] also have been reported to improve glucose metabolism.
  • Testosterone replacement therapy has been reported to improve some or all of the components of the MetS.
  • Nathan Goodyear on 02 Mar 15
     
    To be read article on Testosterone and Metabolic Syndrome.
Nathan Goodyear

Hormonal Modulation in Aging Patients with Erectile Dysfunction and Metabolic Syndrome - 0 views

www.ncbi.nlm.nih.gov/...PMC3888699

low T Testosterone hypogonadism MetS metabolic syndrome men male hormone hormones

shared by Nathan Goodyear on 05 Feb 14 - No Cached
  • Hypogonadism and MetS are strongly associated [12, 13, 16], having even been demonstrated that with the increasing number of MetS parameters there is a proportional raise in the incidence of hypogonadism
  • increasing number of MetS components is inversely associated with T levels
  • the presence of MetS did not prove to be a significant determinant of hypogonadism, as it did not lead to a decline in T levels, in MetS patients with already established hypogonadism, the increasing number of MetS features was associated with further decline in T
  • ...15 more annotations...
  • In the setting of MetS, hypertriglyceridemia and increased WC have been reported as the most important determinants of hypogonadism
  • recent literature consistently associates obesity not only with higher risk of hypogonadism [4, 6, 27] but also with lower T levels
  • Visceral adiposity has been particularly related with reduction of T and SHBG levels (independent of other metabolic disorders)
  • WC was one of the MetS parameters with the greatest influence in T levels decrease, presenting itself as a strong risk factor for hypogonadism development
  • MetS-related T decline was not accompanied by an increase in pituitary LH levels, suggesting impairment in gonadotropin secretion
  • The molecules behind this smoothing compensatory effect of GnRH/LH are still unknown, but estrogens and insulin, as well as leptin, TNF-α, and other adipokines, were proposed candidates
  • fat stores undertake an increase aromatization of androgens, therefore raising estrogen levels [9, 15], which in turn decrease LH secretion
  • our data contradicts the concept that estradiol exerts a negative feedback on hypothalamic GnRH secretion
  • taking into account that high estradiol levels have already been described as the only abnormality in a subset of patients with ED, the hypothesis that the later might not only be caused by androgen deficiency is becoming increasingly evident
  • it has been reported that the chronic exposure to phosphodiesterase type 5 inhibitors (PDE5i), widely used for the treatment of ED, may influence serum estradiol levels
  • thyroid disorders (specially hyperthyroidism) have been related to ED and hypogonadism, and so must be considered in a sexual-dysfunction setting
  • It is clear from the current literature that collecting a more thorough hormonal panel might be a wise approach to further uncover hormonal relations
    • Nathan Goodyear
      Nathan Goodyear on 05 Feb 14
       
      outstanding point.  This hits to the point that Low T is the effect not the cause.
  • We concluded that in ED patients with hypogonadism and MetS, the attenuated response of HPG axis (normal or low LH levels) might not always be due to an underlying adiposity-dependent estrogen-raising effect.
  • our findings indicate that ED, aging, and estradiol might have a stronger connection than what is currently described in the literature.
  • this study underlines the importance of the collection of a full hormonal panel in ED men
  • Nathan Goodyear on 05 Feb 14
     
    low T strongly associated with metabolic syndrome in men.
Nathan Goodyear

Testosterone and metabolic syndrome: The link - 0 views

www.ncbi.nlm.nih.gov/...PMC3354945

low T testosterone MetS metabolic syndrome men male

shared by Nathan Goodyear on 05 Nov 12 - No Cached
  • Nathan Goodyear on 05 Nov 12
     
    good discussion on whether low T is the cause of MetS or is the result of MetS.  I am of the camp that believes that low T is required for MetS to develop in men.
Nathan Goodyear

The relationship between lower urinary tract symptoms/benign prostatic hyperplasia and ... - 0 views

www.ncbi.nlm.nih.gov/...23850334

metabolic syndrome LUTS prostate BPH men male hormone hormones

shared by Nathan Goodyear on 27 May 15 - No Cached
  • Nathan Goodyear on 27 May 15
     
    Correlation found between increasing MetS components and LUTS/BPH incidence.  This points to more of a inflammatory, estrogen contribution, rather than an excess Testosterone issue as MetS is associated clearly with low T in men with MetS.
Nathan Goodyear

The relationship between testosterone, metabolic syndrome, and mean carotid intima-medi... - 0 views

informahealthcare.com/...13685538.2014.958458

low T Testosterone low T low Testosterone aging male metabolic syndrome metabolic syndrome IMT carotid intima-media thickness men hormone hormones

shared by Nathan Goodyear on 12 Sep 14 - No Cached
  • Nathan Goodyear on 12 Sep 14
     
    Low Testosterone is associated with increased IMT.  Low T is associated with Mets.  MetS is associated with low T.  MetS is associated with increased IMT.
Nathan Goodyear

Both total testosterone and sex hormone-binding globulin are independent risk factors f... - 0 views

onlinelibrary.wiley.com/...abstract

metabolic syndrome men male hormone hormones Total Testosterone free bioavailable SHBG low T low Testosterone

shared by Nathan Goodyear on 06 Aug 14 - No Cached
  • Nathan Goodyear on 06 Aug 14
     
    Study of 2361 Chinese men found that men with MetS had lower TT, bioavailable Testosterone, free Testosterone and SHBG than those men without MetS.  Additionally, Total Testosterone and SHBG were both inversely associated with the risk of MetS.  This inverse association stood for both after adjusting for the other.
Nathan Goodyear

Metabolic syndrome in men with low testosterone le... [J Sex Med. 2013] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23898860

metabolic syndrome low testosterone T MetS men male hormone hormones ED obesity alcohol peripheral vascular disease

shared by Nathan Goodyear on 06 Feb 14 - No Cached
  • Nathan Goodyear on 06 Feb 14
     
    Metabolic syndrome and Low T definitely run together.  Whether one causes the other or merely associations, they reflect the risk of the other.  It is known that increasing MetS parameters drives the Testosterone lower.  In this study, they found ED, obesity, PVD, and Etoh intake associated with increased incidence of MetS.  ED and obesity are both associated with low T.
Nathan Goodyear

Sex hormone binding globulin, but not testosterone, is associated with the metabolic sy... - 0 views

europepmc.org/...23812344

metabolic syndrome metabolic syndrome MetS PCOS women hormone hormones Testosterone obesity obese insulin resistance SHBG

shared by Nathan Goodyear on 12 Mar 14 - No Cached
  • Nathan Goodyear on 12 Mar 14
     
    This study finds an association between low SHBG and increased metabolic syndrome in obese women with PCOS.  Testosterone was not associated.  Other studies have shown a positive association between Testosterone and MetS in women.  This follows men in that SHBG shows an association with MetS.  Only the abstract is present here, so I can't look at the data presented.
francois appers

Extra energie tegen vermoeidheid - 0 views

www.leefnugezonder.be/tra-energie-tegen-vermoeidheid

lente voorjaar moe vermoeid voorjaarsmoeheid oorzaken energietekort extra energie vitaminen mineralen voedingssupplementen

shared by francois appers on 28 Mar 12 - No Cached
  • francois appers on 28 Mar 12
     
    Lang niet iedereen reageert niet even enthousiast over de komst van de lente. Ruim 500000 landgenoten kampen in het vroege voorjaar met lentemoeheid en ernstig energietekort. Wat zijn de oorzaken van voorjaarsmoeheid en tekort aan energie en hoe kun je er aan verhelpen? Kunnen extra vitaminen of voedingssupplementen je helpen ontwaken uit je winterslaap om met volle teugen te genieten van het deugddoende buitenleven?
Nathan Goodyear

Testosterone, sex hormone-binding globulin and the metabolic syndrome: a systematic rev... - 0 views

ije.oxfordjournals.org/...189.long

metabolic syndrome hormone hormones Testosterone SHBG

shared by Nathan Goodyear on 30 Aug 13 - No Cached
  • Nathan Goodyear on 30 Aug 13
     
    large meta analysis finds low Total Testosterone associated with in men and high Total Testosterone associated with MetS in women.  lower SHBG is associated with MetS
Nathan Goodyear

Journal of Ovarian Research | Full text | Evaluation of the ovarian reserve function in... - 0 views

www.ovarianresearch.com/...63

Testosterone women metabolic syndrome metabolic syndrome hormone hormones

shared by Nathan Goodyear on 25 Jun 14 - No Cached
  • Nathan Goodyear on 25 Jun 14
     
    Study finds decreased ovarian reserve in women 20-29 with metabolic syndrome compared to controls.  They determined this via ovarian volume measurements as FSH, LH, Estradiol, and Progesterone did not differ.   One item of interest was that women with MetS, had significantly higher Testosterone levels compared to controls.  This association of MetS and elevated Testosterone in women has been shown consistently in the literature.  This should bring great questions to the doping of Testosterone in women today.
Nathan Goodyear

The association between hyperandrogenemia and the metabolic syndrome in morbidly obese ... - 0 views

www.ncbi.nlm.nih.gov/...PMC4443598

metabolic syndrome obesity Testosterone PCOS hormone hormones hyperandrogenemia

shared by Nathan Goodyear on 04 Jun 15 - No Cached
  • a significant inverse relationship between HA and HDL-cholesterol levels which is in accordance with previous studies of women with PCOS
  • HA was associated with 61 % increased adjusted odds of MetS, and that this association was mainly driven by increased odds of dysglycemia and dyslipidemia
  • the prevalences of MetS, PCOS and HA were high among morbidly obese women <50 years of age
  • ...3 more annotations...
  • Compared to women without HA, those with HA had significantly higher odds of having the MetS, which was mainly explained by the associations between HA and the lipid- and glucose components of the MetS
  • FTI-blood test might add value to the cardiovascular risk assessment of premenopausal women with morbid obesity
  • We calculated the free testosterone index (FTI) using the formula: FTI = 100 x serum testosterone (nmol/L) / sex hormone binding globulin (SHBG, nmol/L)
  • Nathan Goodyear on 04 Jun 15
     
    Another study that finds hyperandrogenism in women is associated with increased Metabolic Syndrome.  This study found obesity was associated with increased hyperandrogegism and Metabolic Syndrome irregardless of PCOS diagnosis or not.
francois appers

Vakantie in zicht: waa op letten bij huur to? - 0 views

www.leerwiki.nl/_waar_op_letten_bi_uur_auto%3F

vakantie auto huren hoe voordelig verzekering autohuur

shared by francois appers on 10 May 11 - No Cached
  • francois appers on 10 May 11
     
    Met de zomervakantie in zicht, ligt bij de meerderheid van onze landgenoten hun vakantiebestemming ongetwijfeld al geruime tijd vast. Maar hoe is het gesteld met het huren van een auto op onze toekomstige vakantiebestemming? Welk prijskaartje hangt er aan vast, en op wat moeten we zeker letten willen we tijdens onze vakantie voor geen onoverkomenlijke hindernissen worden geplaatst?
francois appers

Soep en extra hyghiëne helpen tegen verkoudheden - 0 views

leefgezonder.blogspot.com/...tra-hyghiene-helpen-tegen.html

giep verkoudheid behandeling kippensoep tegen soep extra hygiëne

shared by francois appers on 24 Aug 11 - No Cached
  • francois appers on 24 Aug 11
     
    Met de start van het nieuwe schooljaar begint meteen ook een nieuw nies en snotterseizoen. Inderdaad, het duurt niet langer dan twee weken of onze hartediefjes komen met hun eerste, maar lang niet de laatste verkoudheid naar huis. Eens de virussen en bacteriën binnenskamers, nestelen ze er zich meestal voor een ganse winter. Het aantal hoesters, niezers en snottebellen zal de komende weken en maanden angstaanjagend stijgen, om tijdens de eindejaarsfeesten naar een hoogtepunt te klimmen. Is er dan niets tegen verkoudheden opgewassen? Wat kunnen we zélf ondernemen om van deze vervelende verkoudheden gespaard te blijven? Kunnen we ons wel wapenen tegen verkoudheden?
Nathan Goodyear

Prevalence of Hyperuricemia and the Relationship between Serum Uric Acid and Metabolic ... - 0 views

www.jstage.jst.go.jp/..._article

uric acid metabolic syndrome triglycerides waist circumference hormones hormone inflammaiton

shared by Nathan Goodyear on 27 Aug 14 - No Cached
  • Nathan Goodyear on 27 Aug 14
     
    Waist circumference and triglycerides correlate with serum uric acid levels.  Men in this study had higher hyperuricemic rates compared to women.  Elevated uric acid levels were associated with increased MetS in both sexes and higher normal uric acid levels were also associated with a higher risk of MetS.
Nathan Goodyear

Testosterone and metabolic syndrome: a meta-analysis study. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...20807333

Testosterone metabolic syndrome glucose HOMA triglycerides waist circumference HDL men male hormone hormones

shared by Nathan Goodyear on 03 Mar 15 - No Cached
  • Nathan Goodyear on 03 Mar 15
     
    Men with metabolic syndrome have lower Testosterone levels when compared to "healthy" individuals.  All men with MetS should have a full androgen analysis performed.  This meta-analysis of 20 studies found Testosterone therapy reduced fasting glucose, HOMA, triglycerides, waist circumference by Testosterone in men with MetS.  This study found that Testosterone therapy increased HDL as well.
Nathan Goodyear

Metabolic Syndrome Components Are Associated with Future Medical Costs Independent of C... - 0 views

www.ncbi.nlm.nih.gov/...PMC3125563

metabolic syndrome metabolic syndrome costs health care costs health

shared by Nathan Goodyear on 02 Aug 14 - No Cached
  • Nathan Goodyear on 02 Aug 14
     
    The costs of MetS increase with each MetS criteria.
Nathan Goodyear

Methionine enkephalin (MENK) improved the functions of bone marrow-derived dendritic ce... - 0 views

www.ncbi.nlm.nih.gov/...PMC3579904

cancer MET-enkephalin MET-5

shared by Nathan Goodyear on 15 Aug 21 - No Cached
  • Nathan Goodyear on 15 Aug 21
     
    MET-enkephalin acts as an immunomodulator via dendritic cell and CD8 activity
Nathan Goodyear

Methionine enkephalin (MENK) mounts antitumor effect via regulating dendritic cells (DC... - 0 views

pubmed.ncbi.nlm.nih.gov/28088065

MET-enkephalin MET-5 dendritic cell cancer

shared by Nathan Goodyear on 15 Aug 21 - No Cached
  • Nathan Goodyear on 15 Aug 21
     
    MET-enkephalins provides anti-tumor activity via opioid receptors on Dendritic cells.
Nathan Goodyear

Methionine Enkephalin | SpringerLink - 0 views

link.springer.com/...978-1-4899-0059-3_19

cancer NK cells MET-enkephalin CD8 MET-5

shared by Nathan Goodyear on 15 Aug 21 - No Cached
  • Nathan Goodyear on 15 Aug 21
     
    MET-enkephalin similar to IL-2 in its NK cell and CD8 stimulation.
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