"CNB was found to promote the lung metastasis of breast cancer, and the underlying mechanism may be associated with epithelial‑to‑mesenchymal transition (EMT) mediated by the TGF‑β1 signaling pathway."
CNB creates an immunosuppressive tumor microenvironment, increases EMT, and facilitates release of CTCs, all of which likely contribute to the observed increase in development of distant metastases.