study of middle aged men (mean age--50) finds no correlation between Testosterone, DHT, and higher Estradiol levels in CVD outcomes, including mortality. Men who died during the study had lower total Testosterone, free Testosterone, and DHT levels than those that survived during the study.
This study shows that DHT is a good alternative androgen to Testosterone. It was shown to have no positive/negative effect on the prostate. The negative of this study was found to be bone loss from supra physiologic DHT. The point there is to keep hormone replacement physiologic, as one should with all BHRT.
This is in contrast to studies that show poor prognosis with Lower T at time of diagnosis of prostate cancer
5α-reductase not only provides a potent amplification of the androgenic signal (
4–
6), but it also prevents estrogen formation by subtracting testosterone from the action of aromatase (
7,
8), thus blocking activation of the estrogen receptor subtypes (ERα and ERβ; refs.
9,
10)
ERβ is the prevailing subtype (
11), and a growing body of evidence points to the protective role of this receptor in prostate cancer
It has been shown that the transformation of the dihydrotestosterone to 5α-androstane-3α,17β-diol (3α-diol) and 5α-androstane-3β,17β-diol
(3β-Adiol), generates two metabolites unable to bind the androgen receptor, but possessing a very high affinity for the estrogen
receptors
the effects of testosterone may result from the balance between the androgenic and the estrogenic molecules
originating from its catabolism.
Recent data have been published postulating a direct estrogenic role of the 3β-hydroxylated
derivatives of dihydrotestosterone in the prostate development and homeostasis
DHT at 70 mg daily shown to have no adverse effects in the prostate of "healthy" men older than 50. However, it did increase DHT metabolites (3 alpha androstane-diol and 3 beta androstane-diol), decreased LH, Testosterone, Estradiol, FSH, increased hemoglobin, creatinine, lean mass and decreased fat.
Older men, 70-89, Testosterone in the middle range of normal and higher DHT was associated with the lowest death rates. Estradiol was not found to be associated. This study only looked at Total levels, free bioavailable levels were not assessed. This study also highlights the basic thought, that more is not always better as it pertains to Testosterone. It also highlights the importance of DHT. Testosterone is a pro hormone.
Australian study of older men, 70-89, found that normal Testosterone and DHT levels were associated with lower death rates. This is important as this is the first study to find the positive health benefit of DHT as well as Testosterone.
Abstract published ahead of print finds that DHT and calculated free DHT was associated with CVD and all-cause mortality. This cohort found that Total Testosterone and calculated free Testosterone were not.
Sochastic sensors and pattern recognition proposed to improve levels of Estradiol, Testosterone, and DHT in salivary sampling in young children. These levels are very low in pre-pubertal children and makes detection by ELIZA difficult. This proposed mechanism improves hormone detection.
Higher Testosterone and DHT levels in men was found to be positively associated with FEV1 and FVC; Estradiol was not. The question here is cause or effect.
Also interesting is the fact that smokers had higher Testosterone levels compared to non-smokers.
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