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Nathan Goodyear

Circulating 2-hydroxy and 16-α hydroxy estrone levels and risk of breast canc... - 1 views

www.ncbi.nlm.nih.gov/...PMC2562592

estrogen metabolism menopause post-menopause post menopause estrogen metabolite 2-OH-estrone 16-alpha-OH-estrone 2:16alpha-OH estrone breast cancer risk hormone hormones

shared by Nathan Goodyear on 21 Aug 14 - No Cached
  • 2-OH estrogens bind to the estrogen receptor (ER) with affinity equivalent to or greater than estradiol
  • previous prospective studies have not observed any significant associations with either 2-OH or 16α-OH estrone or the ratio of the two metabolites and breast cancer risk overall.
    • Nathan Goodyear
      Nathan Goodyear on 08 Oct 15
       
      whether that risk is increased or decreased
  • it has been hypothesized that metabolism favoring the 2-OH over the 16α-OH pathway may be inversely associated with breast cancer risk (28).
  • ...24 more annotations...
  • they may act as only weak mitogens (14, 15), or as inhibitors of proliferation
  • No significant associations have been observed between 2-OH estrone and breast cancer risk
  • While 16α-OH estrone binds to the ER with lower affinity than estradiol, it binds covalently (18-20) and once bound, fails to down-regulate the receptor (21). Thus, 16α-OH estrone stimulates cell proliferation in a manner comparable to estradiol in ER+ breast cancer cell lines
  • In this large prospective study of 2-OH and 16α-OH estrone metabolites and breast cancer risk, we did not observe any significant associations overall with either individual metabolite or with the ratio of the two metabolites
  • we observed positive associations with 2-OH estrone and the 2:16α-OH estrone ratio among women with lower BMI and women with ER-/PR-tumors,
  • To date, several epidemiologic studies have examined the association between the 2-OH and 16α-OH estrogen metabolites and breast cancer risk with inconclusive results.
  • circulating estrogen levels have been associated more strongly with ER+/PR+ tumors than with ER-/PR- tumors
  • our results do not support the hypothesis that metabolism favoring the 2-OH estrone pathway is more beneficial to breast cancer risk than that favoring the 16α-OH estrone pathway
  • we observed significant positive associations of both 2-OH estrone and the 2:16α-OH estrone ratio with ER-/PR-tumors
  • Three (30, 32, 33) of four (30-33) studies observed RRs above 1 for the association between 16α-OH estrone and breast cancer risk (range of RRs=1.23-2.47); none of the point estimates was statistically significant though one trend was suggestive
  • based on animal studies, 2-OH estrone and the 2:16α-OH estrone ratio have been hypothesized to be inversely associated with breast cancer risk
  • No significant associations have been observed between 2-OH estrone, 16α-OH estrone, or the 2:16α-OH estrone ratio and breast cancer risk and the direction of the estimates is not consistent across studies.
    • Nathan Goodyear
      Nathan Goodyear on 08 Oct 15
       
      better worded is no consistent, significant associations.   There are some studies that point to the 16 catecholestrogen and increased cancer risk; limited studies show negative effects of 2 catecholestrogens on cancer risk and prospective studies available pretty much dispel the idea that the 2:16 ratio has an risk predictability.
  • we observed a suggestive inverse association with 16α-OH estrone and a significant positive association with the 2:16α-OH estrone ratio among lean women, suggesting possible associations in a low estrogen environment.
  • 16α-OH estrone increases unscheduled DNA synthesis in mouse mammary cells (27) and hence also may be genotoxic
  • Although 2-OH estrogens are capable of redox cycling, the semiquinones and quinones (i.e., the oxidized forms) form stable DNA adducts that are reversible without DNA destruction
  • In our population of PMH nonusers, we observed no associations with ER+/PR+ tumors, but significant positive associations with 2-OH estrone and the 2:16α-OH estrone ratio among women with ER-/PR- tumors
    • Nathan Goodyear
      Nathan Goodyear on 08 Oct 15
       
      one of the few studies to find this association between 2 catecholestrogens and the 2:16 ratio and ER-/PR-tumors
  • Animal and in vitro studies have shown that hydroxy estrogens can induce DNA damage either directly, through the formation of quinones and DNA adducts, or indirectly, through redox cycling and the generation of reactive oxygen species
    • Nathan Goodyear
      Nathan Goodyear on 08 Oct 15
       
      genotoxic via directe DNA adducts and indirectly via ROS; this is in addition to the proliferative effect
  • we observed a significant positive association between the 2:16α-OH estrone ratio and breast cancer risk among lean women
  • No significant associations have been observed with the 2:16α-OH estrone ratio
  • In the Danish study, no associations were observed with either ER+ or ER- tumors among PMH nonusers
  • significant positive associations with 2-OH estrone and the 2:16α-OH estrone ratio were observed among PMH users with ER+, but not ER-, tumors
  • it is possible that the genotoxicity of 2-OH estrone plays a role in hormone receptor negative tumors
  • 4-OH estrogens have a greater estrogenic potential than 2-OH estrogens, given the lower dissociation rate from estrogen receptors compared with estradiol (61), and are potentially more genotoxic since the quinones form unstable adducts, leading to depurination and mutation in vitro and in vivo
  • the balance between the catechol (i.e., 2-OH and 4-OH) and methoxy (i.e., 2-Me and 4-Me) estrogens may impact risk
  • Nathan Goodyear on 21 Aug 14
     
    The risks of estrogen metabolism are not clear cut.  Likely never will be due to the complexity of individual metabolism.  This study found no correlation between 2OH-Estrone and 2OH:16alpha-Estrone and breast cancer risk in ER+/PR+ breast cancer.  Translated: no benefit in breast cancer risk in 2OH-Estrone metabolism or increased 2OH:16alpha estrone metabolism.  There was a positive association between 2OH-Estrone and 2:16alpha-Estrone in women with ER-/PR- tumors and low BMI.
  • anonymous on 28 Oct 15
     
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anonymous

Fondazione Belladonna Onlus: La festa dei pazienti - 0 views

fondazionebelladonnaonlus.blogspot.com/...la-festa-dei-pazienti.html

#homeopathy

shared by anonymous on 01 Apr 15 - No Cached
  • anonymous on 01 Apr 15
     
    10 April 2015 festivity for mondial day of homeopathy
Nathan Goodyear

The Ketogenic Diet and Sport: A Possible Marriage? : Exercise and Sport Sciences Reviews - 0 views

journals.lww.com/..._and_Sport___A_Possible.8.aspx

nutrition diet ketogenic ketogenic diet sports athletes exercise sports medicine

shared by Nathan Goodyear on 16 Nov 16 - No Cached
  • It is important to note that, although the blood level of glucose drops, it still remains at a physiological level (23), which is maintained through gluconeogenesis involving glucogenic amino acids and also glycerol released from triglycerides
  • “physiological ketosis” where KB levels may rise to 7 to 8 mmol L-1 (but without any pH change). In “pathological diabetic ketoacidosis,” on the other hand, ketonemia can exceed 20 mmol L-1 and also cause lowering of blood pH
  • in the initial phase of KD, about 16% of glucose comes from glycerol (released from triglyceride hydrolysis) and the bulk (60–65 g) from proteins via gluconeogenesis (proteins may be of either dietary or endogenous origin
  • ...5 more annotations...
  • the protein supply consumed during a KD “preserves,” as demonstrated, lean body mass
  • The importance of glycerol as a glucose source increases progressively during ketosis; in fact, glycerol passes from supplying 16% of total glucose to an average of 60% after many days (>7 d) of complete fasting (from 38% in lean individual to 79% in the obese).
  • The possible reasons for the effectiveness of KD for weight loss may be listed as follows, in order of evidence, strongest first: Figure 3Image Tools 1. Appetite reduction: protein satiety, effects on appetite-related hormones such as ghrelin, and possibly a sort of direct appetite-blocking effect of KB 2. Reduced lipogenesis and increased fat oxidation 3. A reduction in respiratory quotient may indicate a greater metabolic efficiency in fat oxidation 4. A thermic effect of proteins and increased energy usage by gluconeogenesis
  • all data regarding biochemical and molecular mechanisms suggest that it is very difficult to increase muscle mass during a KD; use of which really should be limited to the few days immediately before competition in bodybuilding.
  • a long-term KD can interfere with some muscle hypertrophy mechanisms and this could be counterproductive if the aim of the athlete is to gain muscle mass
  • Nathan Goodyear on 16 Nov 16
     
    Great read on the ketogenic  and its application to sports/training...
Nathan Goodyear

http://www.drperlmutter.com/wp-content/uploads/2015/12/Pandit_et_al-Acta_Neurologica_Sc... - 0 views

www.drperlmutter.com/...a_Neurologica_Scandinavica.pdf

statin statin therapy statins brain side effects brain health brain hemorrhage hemorrhage

shared by Nathan Goodyear on 19 Jan 17 - No Cached
  • Nathan Goodyear on 19 Jan 17
     
    study finds significant increase in risk of intracerebral (brain) hemorrhage with high dose statin therapy.  The "high dose" seems to be a fairly regular dose by the patients that walk through my office doors.  This is a meta-analysis
Nathan Goodyear

Intermediate and Longer-Term Outcomes From a Prospective Active-Surveillance Program fo... - 0 views

jco.ascopubs.org/...JCO.2015.62.5764.full

prostate cancer prostate cancer men

shared by Nathan Goodyear on 02 Sep 15 - No Cached
  • Nathan Goodyear on 02 Sep 15
     
    low aggressive prostate cancer followed conservatively results in low mortality rate in study.  The study is significant in that it followed 1,298 men up to 18 years and found reclassification to "lethal" grade prostate cancer to be only 5.9%.  This challenges long held dogma that the first approach to cancer is to cut it out. For those with low aggressive prostate cancer, conservative approaches i.e. observation, can be employed.
Nathan Goodyear

The dose-response effect of physical activity on cancer mortality: findings from 71 pro... - 0 views

bjsm.bmj.com/...bjsports-2015-094927.short

cancer exercise mortality sports medicine

shared by Nathan Goodyear on 06 Oct 15 - No Cached
  • Nathan Goodyear on 06 Oct 15
     
    2.5 hours of moderate intensity exercise found to reduce cancer mortality.  The effect was even more profound in cancer survivors.  
Shelia Morales

Benefits of Cosmetics & Skincare in Maryville | Belleville | St. Louis - 0 views

www.kristenjacobs.com/.

Skincare Belleville Skincare Maryville botox St. louis Skincare Swansea fillers Belleville fillers Swansea Skincare St. louis botox Shiloh fillers St. louis fillers O'fallon botox O'fallon Skincare Fairview heights

shared by Shelia Morales on 23 Jan 15 - No Cached
  • Shelia Morales on 23 Jan 15
     
    As a scientific advisor for ColoreScience, Dr. Jacobs strongly believes in its proven anti-aging and wellness benefits. Dr. Jacobs was invited to speak at the highly anticipated ColoreScience product launch of "even up," set to release February 15, 2015.
laabidi1987

If offered a picture of an unknown woman in front of a man, and asked him if he liked it? - 0 views

www.weightloss24.tk/...arousal-vary-according-to.html

hormones hormone Testosterone cancer men disease inflammation male obesity low weight loss Nutrition Beauty Fitness Health tips

shared by laabidi1987 on 28 Feb 15 - No Cached
  • laabidi1987 on 28 Feb 15
     
    His answer would be probably after a little thinking: "Yes" or "No", he will know the answer clearly and completely. But if our offer image unknown man and we raised the same question on the mirror, it will be assumed her answer: "I'm still not sure, it comes to how I would feel after in-depth knowledge and deal with it, and maybe then you will know." Difference in libido between the sexes! Differences in approach in the expression of feelings is not a coincidence, it is a clear and distinct. Is it possible that women are more reluctant than men? Or maybe the point of view based on the components did not know the men? Studies suggest that women need more information to see her passion and expression of feelings toward the man standing front of them, including. http://www.weightloss24.tk/2015/02/is-sexual-arousal-vary-according-to.html
Richard Joseph

Eyeglasses & Eyewear Specials in St. Louis | Mobypicture - 0 views

www.mobypicture.com/...17911795

Eyeglasses in O'Fallon

shared by Richard Joseph on 13 Mar 15 - No Cached
  • Richard Joseph on 13 Mar 15
     
    Don't miss out on this great promotion! Enjoy up to 30% off every eyeglasses & Eyewear product in St. Louis, IL area. See office for details. This offer ends March 31, 2015.
star yu

2015 Clínica Día Mundial del Riñón-Free Medical Consulta De Shijiazhuang Hosp... - 0 views

www.enfermedad-renal.com/...2099.html

2015 Clínica Día Mundial del Riñón-Free Medical Consulta

shared by star yu on 16 Mar 15 - No Cached
  • star yu on 16 Mar 15
     
    En el día del décimo Día Mundial del Riñón, Shijiazhuang Hospital de Enfermedades del Riñón celebró su clínica anual gratuito consulta médica,lo que significa una gran cantidad de personas que están luchando con esta enfermedad y la prevención de esta enfermedad.
Nathan Goodyear

Androgen Deprivation Therapy and Future Alzheimer's Disease Risk - 0 views

jco.ascopubs.org/...JCO.2015.63.6266

ADT androgen deprivation therapy low T low Testosterone alzheimer's disease Alzheimer's brain

shared by Nathan Goodyear on 30 Dec 15 - No Cached
  • Nathan Goodyear on 30 Dec 15
     
    Androgen deprivation therapy appears to increase Alzheimer's disease risk.  In this study, the men on ADT the longest was found to be associated with increased diagnosis of Alzheimer's disease.
Nathan Goodyear

Estrogenic compounds reduce influenza A virus replication in primary human nasal epithe... - 0 views

ajplung.physiology.org/...ajplung.00398.2015

flu influenza virus estrogen ER beta ER-beta hormones

shared by Nathan Goodyear on 10 Feb 16 - No Cached
  • Nathan Goodyear on 10 Feb 16
     
    this is a pdf article only and not much is available for public read: estrogen found to have antiviral activity against influenza A in women via ER-beta activation.
Nathan Goodyear

Androgen Deprivation Therapy and Future Alzheimer's Disease Risk - 0 views

jco.ascopubs.org/...JCO.2015.63.6266.abstract

alzheimer's disease prostate cancer ADT androgen deprivation therapy male hormones Testosterone

shared by Nathan Goodyear on 09 Dec 15 - No Cached
  • Nathan Goodyear on 09 Dec 15
     
    new risk potential for Androgen Deprivation Therapy (ADT) for men with prostate cancer--increased Alzheimer's disease risk.
Nathan Goodyear

Salivary cortisol and testosterone responses to resistance and plyometric exercise in 1... - 0 views

www.nrcresearchpress.com/...apnm-2015-0668

resistance training exercise testosterone cortisol hormones male hormones

shared by Nathan Goodyear on 16 May 16 - No Cached
  • Nathan Goodyear on 16 May 16
     
    Study of 12-14 y/o boys found increased Testosterone after resistance training and plyometric exercise.  Cortisol did increase after plyometric, but not resistance exercise.
Nathan Goodyear

A Natural Product Telomerase Activator Lengthens Telomeres in Humans: A Randomized, Dou... - 0 views

online.liebertpub.com/...rej.2015.1793

TA-65 Telomerase telomerase activator Telomeres aging wellness health natural

shared by Nathan Goodyear on 16 May 16 - No Cached
  • Nathan Goodyear on 16 May 16
     
    low dose TA-65, which is a telomerase activator found to significantly lengthen Telomeres in human randomized study.
Nathan Goodyear

Delayed Neuroendocrine Sexual Maturation in Female Rats After a Very Low Dose of Bisphe... - 0 views

press.endocrine.org/...en.2015-1937

BPA toxins environmental toxins xenoextrogens bisphenol A hormones

shared by Nathan Goodyear on 18 May 16 - No Cached
  • Nathan Goodyear on 18 May 16
     
    low dose of BPA in rat model finds delayed sexual maturation.
Nathan Goodyear

Low Free Testosterone Is Associated with Hypogonadal Signs and Symptoms in Men with Nor... - 0 views

press.endocrine.org/...jc.2015-4106

low T low testosterone Testosterone free Testosterone male hormones hormones men

shared by Nathan Goodyear on 19 Sep 16 - No Cached
  • Nathan Goodyear on 19 Sep 16
     
    low free Testosterone, though calculated in this study, found to be associated with low T symptoms despite normal total Testosterone.  Though the "normal" total Testosterone in this study is abnormal low in other studies.  Only abstract available.
Nathan Goodyear

Aspartame intake is associated with greater glucose intolerance in individuals with obe... - 1 views

www.nrcresearchpress.com/...apnm-2015-0675

aspartame obesity glucose intolerance insulin resistance

shared by Nathan Goodyear on 25 Nov 16 - No Cached
  • Nathan Goodyear on 25 Nov 16
     
    aspartame worsens glucose intolerance in obese individuals.
star yu

Proteinuria y Creatinina Sérica Alta en Insuficiencia Renal Puede Ser Control... - 0 views

www.hospitalrenal.com/...1434.html

FSGSla insuficiencia renalla creatininael tratamiento

shared by star yu on 04 May 16 - No Cached
  • star yu on 04 May 16
     
    MUHAMMAD ZUBAIR es un hombre de 41 años, el 10 de abril, el año 2015 llegó a Shijiazhuang Hospital de Enfermedades del Riñón por primera vez a buscar un tratamiento adicional. Antes de venir aquí,ha sufrido de la proteinuria de 10 años y creatinina sérica alta de 4 años. Después de 43 días de tratamiento, su estado general quedó muy mejorado. En los siguientes son algunos detalles sobre su condición de enfermedad, vamos a echar un
star yu

Shijiazhuang Hospital de Enfermedades del Riñon Trata la Proteinuria en Diabe... - 0 views

www.hospitalrenal.com/...1435.html

Micro-Medicina China osmoterapiala Diabetesel tratamientomedicial baño de pies

shared by star yu on 04 May 16 - No Cached
  • star yu on 04 May 16
     
    Este es un caso de éxito de la proteinuria en la diabetes ,que se trata con eficacia. Este paciente sufre de diabetes desde hace 15 años. En 2015, fue encontrado que había proteínas en la orina durante un examen físico. Microalbúmina fue de 100 y él no tuvo ningún tipo de tratamiento.
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