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Nathan Goodyear

Ascorbic Acid Chemosensitizes Colorectal Cancer Cells and Synergistically Inhibits Tumo... - 0 views

www.ncbi.nlm.nih.gov/...PMC6064950

cancer vitamin C ascorbic acid colorectal cancer

shared by Nathan Goodyear on 26 Mar 22 - No Cached
  • therapeutic potential has been supported by a large and consistent body of evidences from in vitro
  • Ascorbic acid might act as a way to deliver hydrogen peroxide (H2O2) to the tissues
  • pharmacological concentrations of AA were capable of inducing anti-proliferative, cytotoxic and genotoxic effects
  • ...12 more annotations...
  • chemosensitizing
  • pharmacological concentrations of AA can sensitize cancer cells to chemotherapy, enhancing its antineoplastic effect
  • synergistic effect with conventional chemotherapeutic drugs is a fact already reported, in various types of cancer, by numerous authors, namely in pancreatic (Espey et al., 2011), prostate (Gilloteaux et al., 2014), lung (Lee et al., 2017), breast (Kurbacher et al., 1996; Wu et al., 2017) and ovarian (Ma et al., 2014) cancers.
  • chemosensitizing effect of vitamin C has already been proven by several authors in various types of cancer
  • intravenous pharmacological concentrations, may not only potentiate the effects of conventional chemotherapy, but also improve the quality of life of cancer patients
  • AA reinforced the anti-proliferative activity of 5-FU
  • Combined treatment induced a reduction of 11.5% and 43% in cell viability compared with AA or Iri therapies, respectively, emphasizing the synergistic effect
  • cytotoxic effect occurred with treatment with Iri alone, but also this effect was further potentiated by the presence of AA.
  • association of AA with Oxa showed very promising results, considering that a synergistic effect was demonstrated, in almost all conditions
  • AA and Oxa seem to act synergistically by the activation of the intrinsic pathway of apoptosis, translated on the statistically significant increase of the ratio between BAX and BCL-2 proteins, which in turn is associated with a decrease of Δψm
    • Nathan Goodyear
      Nathan Goodyear on 26 Mar 22
       
      Apoptosis -> decrease in mitochondrial membrane potential
  • Previous results obtained by our group showed that AA mediates reactive oxygen species (ROS) formation capable of irreparably damaging DNA
  • oxidative role of AA may be a key factor on the synergistic anti-cancer mechanism
Nathan Goodyear

O2⋅− and H2O2-Mediated Disruption of Fe Metabolism Causes the Differential Su... - 0 views

www.cell.com/...S1535-6108(17)30062-4

IV vitamin C cancer vitamin C alternative medicine

shared by Nathan Goodyear on 12 Apr 17 - No Cached
  • Nathan Goodyear on 12 Apr 17
     
    IV vitamin C shown to have selective cytotoxicity, no surprise, on lung cancer and glioblastoma cells via H2O2, while at the same time safe to other cells.  
Nathan Goodyear

Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive ... - 0 views

www.pnas.org/...11105

cancer vitamin C

shared by Nathan Goodyear on 06 Oct 18 - No Cached
  • Nathan Goodyear on 06 Oct 18
     
    vitamin C inhibits tumor growth in ascorbate treated mice via prooxidant effect.
Nathan Goodyear

Elimination of Ascorbic Acid After High‐Dose Infusion in Prostate Cancer Pati... - 1 views

onlinelibrary.wiley.com/...bcpt.12323

prostate cancer vitamin C IV vitamin C

shared by Nathan Goodyear on 21 Aug 19 - No Cached
  • Nathan Goodyear on 21 Aug 19
     
    Small study finds that plasma AA levels increase with accumulating doses of weekly IV vitamin C only at 60 gram.
Nathan Goodyear

O2*− and H2O2-Mediated Disruption of Fe Metabolism Causes the Differential Su... - 0 views

www.ncbi.nlm.nih.gov/...PMC5497844

Cancer "vitamin C" "IV vitamin H2O2 Fe ascorbate ascorbic acid redox

shared by Nathan Goodyear on 04 Dec 18 - No Cached
  • Nathan Goodyear on 04 Dec 18
     
    Great read and synopsis of the interaction between vitamin C and the altered redox balance in cancer cells. The process involves Fe in part. Ascorbate increases H2O2 which increases the label Fe pool.
Nathan Goodyear

Tumor cells have decreased ability to metabolize H2O2: Implications for pharmacological... - 0 views

www.ncbi.nlm.nih.gov/...PMC5106370

cancer IV vitamin C vitamin c catalase

shared by Nathan Goodyear on 30 Jan 18 - No Cached
  • Nathan Goodyear on 30 Jan 18
     
    Cancer cells have reduced catalase activity and thus reduced capability to metabolize H202. IV vitamin takes advantage of this deficiency.
Nathan Goodyear

Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a p... - 0 views

www.pnas.org/...13604.abstract

IV vitamin C intravenous therapy treatment cancer

shared by Nathan Goodyear on 14 Nov 11 - No Cached
  • Nathan Goodyear on 14 Nov 11
     
    IV vitamin C shown to be useful aid in cancer treatment
Nathan Goodyear

H2O2-mediated Cytotoxicity of Pharmacologic Ascorbate Concentrations to Neuroblastoma C... - 0 views

www.karger.com/...315098

Ferritin H2O2 vitamin C lactate cancer

shared by Nathan Goodyear on 08 Jul 19 - No Cached
  • Nathan Goodyear on 08 Jul 19
     
    Study finds that ferritin in the tumor microenvironment is critical to the cytotoxicity elicited through its interaction with vitamin C through H2O2.
Nathan Goodyear

Selenium Modulates Cancer Cell Response to Pharmacologic Ascorbate. - Abstract - Europe... - 0 views

europepmc.org/...35916672

glutathione selenium vitamin c cancer

shared by Nathan Goodyear on 23 Dec 22 - No Cached
  • Nathan Goodyear on 23 Dec 22
     
    Selenium deficiency augments high dose vitamin C in glio in vivo study.
Nathan Goodyear

Prooxidative inhibition against NF-κB-mediated inflammation by pharmacologica... - 0 views

www.sciencedirect.com/...S0891584922000181

vitamin C nuclear factor kappa B NF-KappaB v nuclear factor κB inflammation ascorbic acid NF-κB

shared by Nathan Goodyear on 16 Jul 22 - No Cached
  • Nathan Goodyear on 16 Jul 22
     
    The title tells it all.
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