Ascorbic Acid Chemosensitizes Colorectal Cancer Cells and Synergistically Inhibits Tumo... - 0 views
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therapeutic potential has been supported by a large and consistent body of evidences from in vitro
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pharmacological concentrations of AA were capable of inducing anti-proliferative, cytotoxic and genotoxic effects
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pharmacological concentrations of AA can sensitize cancer cells to chemotherapy, enhancing its antineoplastic effect
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synergistic effect with conventional chemotherapeutic drugs is a fact already reported, in various types of cancer, by numerous authors, namely in pancreatic (Espey et al., 2011), prostate (Gilloteaux et al., 2014), lung (Lee et al., 2017), breast (Kurbacher et al., 1996; Wu et al., 2017) and ovarian (Ma et al., 2014) cancers.
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chemosensitizing effect of vitamin C has already been proven by several authors in various types of cancer
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intravenous pharmacological concentrations, may not only potentiate the effects of conventional chemotherapy, but also improve the quality of life of cancer patients
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Combined treatment induced a reduction of 11.5% and 43% in cell viability compared with AA or Iri therapies, respectively, emphasizing the synergistic effect
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cytotoxic effect occurred with treatment with Iri alone, but also this effect was further potentiated by the presence of AA.
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association of AA with Oxa showed very promising results, considering that a synergistic effect was demonstrated, in almost all conditions
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AA and Oxa seem to act synergistically by the activation of the intrinsic pathway of apoptosis, translated on the statistically significant increase of the ratio between BAX and BCL-2 proteins, which in turn is associated with a decrease of Δψm
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Previous results obtained by our group showed that AA mediates reactive oxygen species (ROS) formation capable of irreparably damaging DNA