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Nathan Goodyear

Beneficial effects of a long-term oral L-arginine treatment added to a hypocaloric diet... - 0 views

ajpendo.physiology.org/...E906.full

L-Arginine weight loss diet overweight obesity insulin-resistant diabetic patients

shared by Nathan Goodyear on 09 Jul 11 - No Cached
  • L-arginine supplementation further decreased FM (P < 0.05) and waist circumference (P < 0.0001), preserving FFM (P < 0.03), and improved mean daily glucose profiles (P < 0.0001) and fructosamine (P < 0.03). Moreover, change in area under the curve of cGMP (second messenger of nitric oxide; P < 0.001), superoxide dismutase (index of antioxidant capacity; P < 0.01), and adiponectin levels (P < 0.02) increased, whereas basal endothelin-1 levels (P < 0.01) and leptin-to-adiponectin ratio (P < 0.05) decreased in the L-arginine group.
  • Nathan Goodyear on 09 Jul 11
     
    L-Arginine helps to preserve muscle, while increase fat loss.  This will help to prevent fat rebound in weight loss programs.  Additionally, insulin resistance improved.
Nathan Goodyear

Regulatory role for the arginine-nitric oxide pathway in metabolism of energy substrates - 0 views

www.jnutbio.com/...abstract

L-Arginine NO insulin glucose metabolic syndrome diabetes obesity

shared by Nathan Goodyear on 11 Jul 11 - No Cached
  • Nathan Goodyear on 11 Jul 11
     
    L-Arginine via NO pathway improves insulin/glucose regulation.  Important implications in treatment of metabolic syndrome, diabetes, and obesity
Nathan Goodyear

Erectile dysfunction and testosterone deficiency. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...19011292

PDE5 PDE5 inhibitors PDE5I low T low Testosterone NO nitric oxide ED men hormones Testosterone

shared by Nathan Goodyear on 18 Nov 15 - No Cached
  • Nathan Goodyear on 18 Nov 15
     
    A high percentage of men that fail PDE5 therapy have low T and the addition of T therapy improves the effects of PDE5 therapy.  T provides a positive impact on NO synthase which increased NO, which PDE5 therapies must have to work.
Nathan Goodyear

5-Methyltetrahydrofolate Rapidly Improves Endothelial Function and Decreases Superoxide... - 0 views

circ.ahajournals.org/...1193.long

BH4 5-methyltetrahydrofolate tetrahydrobiopterine MTHFR MTHFR A1298C eNOS NO nitric oxide atherosclerosis cardiovascular disease CVD

shared by Nathan Goodyear on 14 Sep 17 - No Cached
  • Nathan Goodyear on 14 Sep 17
     
    5-MTHF increases BH4 which increases eNOS activity and NO production providing improved endothelial function and thereby providing a mechanism to reduce atherosclerosis.  Interesting that the MTHFR A1298C decreases BH4 in contrast to the 677T.
Nathan Goodyear

Sustaining elevated levels of nitrite in the oral cavity through consumption of nitrate... - 1 views

www.sciencedirect.com/...S1089860316301409

NO nitric oxide

shared by Nathan Goodyear on 24 Aug 17 - No Cached
  • Nathan Goodyear on 24 Aug 17
     
    NO metabolism
Nathan Goodyear

Quercetin Reduces Inflammatory Responses in LPS-Stimulated Cardiomyoblasts - 0 views

www.hindawi.com/...837104

quercetin bioflavonoids LPS lipopolysaccharide iNOS inflammation nitric oxide

shared by Nathan Goodyear on 20 Jun 17 - No Cached
  • Nathan Goodyear on 20 Jun 17
     
    Quercetin lowers LPS levels
Nathan Goodyear

Inhibition of nitric oxide and inflammatory cytokines in LPS-stimulated murine macropha... - 0 views

www.ncbi.nlm.nih.gov/...22698256

quercetin resveratrol pterostilbene iNOS LPS lipopolysaccharides inflammation

shared by Nathan Goodyear on 04 Oct 17 - No Cached
  • Nathan Goodyear on 04 Oct 17
     
    In addition to quercetin, resveratrol and pterostilbene inhibit LPS stimulated cytokine production.
Nathan Goodyear

Vitamin C Pharmacokinetics: Implications for Oral and Intravenous Use | Annals of Inter... - 0 views

annals.org/...lications-oral-intravenous-use

vitamin C IV vitamin C cancer hypertension blood pressure NO nitric oxide

shared by Nathan Goodyear on 20 Dec 17 - No Cached
  • Nathan Goodyear on 20 Dec 17
     
    IV vitamin C found to significantly increased serum levels beyond that of oral.  IV vitamin C is the only route that should be administered for patients with cancer.  IVC at 50 grams showed peak C concentration at 13,400 micromol/L.  Levels of at least 400-600 are required for tumorcidal effects.  In addition, IV vitamin C increased NO release and decreases b/p
Nathan Goodyear

Endothelium and control of vascular function. State of the Art lecture. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...2661425

vitamin C NO nitric oxide blood pressure CV cardiovascular disease hypertension endothelium

shared by Nathan Goodyear on 20 Dec 17 - No Cached
  • Nathan Goodyear on 20 Dec 17
     
    vitamin C, absorbed via the endothelium, increases NO.  This will have a positive effect in lowering the blood pressure.
Nathan Goodyear

Vitamin C inhibits NO-induced stabilization of HIF-1alpha in HUVECs | Request PDF - 0 views

www.researchgate.net/...zation_of_HIF-1alpha_in_HUVECs

Hypoxia-inducible Factor 1 HIF-1alpha vitamin C nitric oxide HIF-1 NO

shared by Nathan Goodyear on 01 Apr 21 - No Cached
  • Nathan Goodyear on 01 Apr 21
     
    Only abstract available. NO increases accumulation of HIF-1alpha and Loading of the cells with vitamin C counteracted NO-induced HIF-1alpha accumulation. It is the HIF-1alpha and HIF-1beta combination that will change genetic expression (epigenetics)
Nathan Goodyear

Immunotherapy of C3H/HeJ mammary adenocarcinoma with interleukin-2, mistletoe lectin or... - 0 views

www.sciencedirect.com/...S0959804901001563

immunotherapy IL-2 mistletoe cancer

shared by Nathan Goodyear on 01 Jun 19 - No Cached
  • Nathan Goodyear on 01 Jun 19
     
    Study finds IL-2 reduces cancer proliferation and metastasis; however, mistletoe alone found to stimulate proliferation, though at very low doses i.e. 1 ng/kg, in mouse model.
Nathan Goodyear

Antitumor effect of pretreatment for colon cancer cells with hyperthermia plus geranylg... - 0 views

pubmed.ncbi.nlm.nih.gov/19337914

nitric oxide colon cancer NO metastasis COX2 matrix metalloproteinase hyperthermia NF-KappaB heat shock proteins MMP HSP HSP70

shared by Nathan Goodyear on 25 Feb 21 - No Cached
  • Nathan Goodyear on 25 Feb 21
     
    Hyperthermia via HSP70 blocks NF-kappaB and all associated downstream signaling that favor metastasis.
Nathan Goodyear

Anti-angiogenic effect of high doses of ascorbic acid - 0 views

www.ncbi.nlm.nih.gov/...PMC2562367

vitamin C angiogenesis nitric oxide NO

shared by Nathan Goodyear on 26 Aug 20 - No Cached
  • Nathan Goodyear on 26 Aug 20
     
    Vitamin C inhibits angiogenesis via suppression of NO levels.
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